2024年 1. Yanagida S, Yuki R, Saito Y, Nakayama Y. LAT1 supports mitotic progression through Golgi unlinking in an amino acid transport activity-independent manner. J. Biol. Chem., 300: 107761, 2024. 2. Yuki R, Kuwajima H, Ota R, Ikeda Y, Saito Y, Nakayama Y. Eph signal inhibition potentiates the growth-inhibitory effects of PLK1 inhibition toward cancer cells. Eur. J. Pharmacol., 963: 176229, 2024. 3. Tanaka J, Kuwajima H, Yuki R, Nakayama Y. Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases. Cell. Signal., 119: 111172, 2024 4. Kitagawa T, Matsumoto T, Ohta T, Yoshida T, Saito Y, Nakayama Y, Hadate Y, Ashihara E, Watanabe T. Linderapyrone analogue LPD‐01 as a cancer treatment agent by targeting importin7. J. Nat. Med., 2024. https://doi.org/10.1007/s11418-023-01774-y 2023年 1. Ota R, Watanabe T, Wazawa Y, Kuwajima H, Honda T, Soeda S, Saito Y, Yuki R, Fukumoto Y, Yamaguchi N-t, Yamaguchi N, Nakayama Y. v-Src delocalizes Aurora B by suppressing Aurora B kinase activity during monopolar cytokinesis. Cell. Signal. 109: 110764, 2023. https://doi.org/10.1016/j.cellsig.2023.110764 2. Ota S, Tanaka Y, Yasutake R, Ikeda Y, Yuki R, Nakayama Y, Saito Y. Distinct effects of heat shock temperatures on mitotic progression by influencing the spindle assembly checkpoint. Exp. Cell Res., 429: 113672, 2023. https://doi.org/10.1016/j.yexcr.2023.113672 3. Yuki R, Ikeda Y, Yasutake R, Saito Y, Nakayama Y. SH2D4A promotes centrosome maturation to support spindle microtubule formation and mitotic progression. Sci. Rep., 13: 2067, 2023. DOI: 10.1038/s41598-023-29362-w 4. Hasegawa N, Hongo M, Okada M, Kuga T, Abe Y, Adachi J, Tomonaga T, Yamaguchi N, Nakayama Y. Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis. Exp. Cell Res., 432: 113783, 2023. 5. Fukumoto Y, Hoshino T, Nakayama Y, Ogra Y. The C-terminal tail of Rad17, iVERGE, binds the 9-1-1 complex independently of AAA+ ATPase domains to provide another clamploader interface. DNA Repair, 130: 103567, 2023. 6. Matsumoto T, Ohnishi E, Kitagawa T, Okayama M, Saito Y, Yoshikawa H, Ohta T, Yoshida T, Nakayama Y, Watanabe T. Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell. Genes Environ., 45: 5, 2023. 2022年 1. Fukumoto Y, Ikeuchi M, Nakayama Y, Ogra Y. Rad17 translocates to nucleolus upon UV irradiation through nucleolar localization signal in the central basic domain. Int. J. Mol. Sci., 23: 12300, 2022. 2021年 1. Ikeuchi M, Yuki R, Saito Y, Nakayama Y. The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner. FASEB J, 35: e21242, 2021. DOI: 10.1096/fj.202001909R 2. Yuki R, Hagino M, Ueno S, Kuga T, Saito Y, Fukumoto Y, Yamaguchi N, Yamaguchi N, Nakayama Y. The tyrosine kinase v-Src modifies cytotoxicities of anticancer drugs targeting cell division J. Cell. Mol. Med., 25: 1677–1687, 2021. DOI: 10.1111/jcmm.16270 3. Morii M, Kubota S, Hasegawa C, Takeda Y, Kometani S, Enomoto K, Suzuki T, Yanase S, Sato R, Akatsu A, Hirata K, Honda T, Kuga T, Tomonaga T, Nakayama Y, Yamaguchi N-t, Yamaguchi N. Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle Sci. Rep., 11: 2616, 2021. doi.org/10.1038/s41598-021-82189-1 4. Ikeda Y, Yasutake R, Yuki R, Saito Y, Nakayama Y. Combination treatment of OSI-906 with Aurora B inhibitor reduces cell viability via cyclin B1 degradation–induced mitotic slippage. Int. J. Mol. Sci., 22: 5706, 2021. https://doi.org/10.3390/ijms22115706 5. Fukumoto Y, Ikeuchi M, Qu L, Hoshino T, Yamaguchi N, Nakayama Y, Ogra Y. Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes. J. Biol. Chem., 297: 100831, 2021 6. Matsumoto T, Kitagawa T, Imahori D, Matsuzaki A, Saito Y, Ohta T, Yoshida T, Nakayama Y, Ashihara E, Watanabe T. Linderapyrone: A Wnt signal inhibitor isolated from Lindera umbellata. Bioorg. Med. Chem. Lett., 45: 128161, 2021 7. Imahori D, Matsumoto T, Saito Y, Ohta T, Yoshida T, Nakayama Y, Watanabe T. Cell death-inducing activities via P-glycoprotein inhibition of the constituents isolated from fruits of Nandina domestica. Fitoterapia, 154: 105023, 2021. 8. Teshima H, Watanabe H, Yasutake R, Ikeda Y, Yonezu Y, Okamoto N, Kakihana A, Yuki R, Nakayama Y, Saito Y. Functional differences between Hsp105/110 family proteins in cell proliferation, cell division, and drug sensitivity. J. Cell. Biochem., 122: 1958-1967, 2021. 2020年 1. Kaibori Y, Katayama K, Tanaka Y, Ikeuchi M, Ogawa M, Ikeda Y, Yuki R, Saito Y, Nakayama Y. Kinase activity-independent role of EphA2 in the regulation of M-phase progression Exp. Cell Res., 395: 112207, 2020. doi.org/10.1016/j.yexcr.2020.112207 2. Matsumoto T, Imahori D, Saito Y, Zhang W, Ohta T, Yoshida T, Nakayama Y, Ashihara E, Watanabe T. Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells J. Nat. Med., 74: 689–701, 2020. doi.org/10.1007/s11418-020-01420-x 3. Munira S, Yuki R, Saito Y, Nakayama Y. ALK inhibitors-induced M phase delay contributes to the suppression of cell proliferation. Cancers, 12: 1054, 2020. doi.org/10.3390/cancers12041054 　＊Faculty Opinions (旧: F1000Prime）で紹介されました。 4. 中山祐治. 受容体型チロシンキナーゼによる細胞分裂制御. 生化学, 92: 253–258, 2020. doi: 10.14952/SEIKAGAKU.2020.920253 5. Matsumoto T, Imahori D, Achiwa K, Saito Y, Ohta T, Yoshida T, Kojima N, Yamashita M, Nakayama Y, Watanabe T. Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus. Fitoterapia, 142: 104524, 2020. doi.org/10.1016/j.fitote.2020.104524 6. Yamagishi A, Ikeda Y, Ikeuchi M, Yuki R, Saito Y, Nakayama Y. Targeting insulin-like growth factor 1 receptor delays M-phase progression and synergizes with Aurora B inhibition to suppress cell proliferation. Int. J. Mol. Sci., 21: 1058, 2020. doi.org/10.3390/ijms21031058 2019年 1.Fukumoto Y, Nakayama Y, Yamaguchi N. Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1 δ/ε and CK2 to promote interaction with the 9-1-1 complex. Biochem. Biophys. Res. Commun., 517: 310-316, 2019. 2. Yamane T, Saito Y, Teshima H, Hagino M, Kakihana A, Sato S, Shimada M, Kato Y, Kuga T, Yamagishi N, Nakayama Y. Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation. J. Cell. Biochem., 120: 17951-17962, 2019. 3. Matozaki M, Saito Y, Yasutake R, Munira S, Kaibori Y, Yukawa A, Tada M, Nakayama Y. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance. Exp. Cell Res., 377: 67-74, 2019. 4. Kaibori Y, Saito Y, Nakayama Y. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M phase progression via maintenance of cortical rigidity. FASEB J, 33: 5334-5349, 2019. 5. Kakihana A, Oto Y, Saito Y, Nakayama Y. Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint. FASEB J, 33: 3936-3953, 2019. 2018年 1. Saito Y, Nakayama Y. 2018. Mammalian heat shock protein Hsp105: The Hsp70 inducer and a potent target for cancer therapy. In: A. A. A. Asea, P. Kaur (eds.): HSP70 in human diseases and disorders, Heat shock proteins 14, Springer Nature. 347-359. 2. Okumura D, Hagino M, Yamagishi A, Kaibori Y, Munira S, Saito Y, Nakayama Y. Inhibitors of the VEGF receptor suppress HeLa S3 cell proliferation via misalignment of chromosomes and rotation of the mitotic spindle causing a delay in M-phase progression. Int. J. Mol. Sci., 19: 4014, 2018. doi:10.3390/ijms19124014 3. Horiuchi M, Kuga T, Saito Y, Nagano M, Adachi J, Tomonaga T, Yamaguchi N, Nakayama Y. The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1. J. Biol. Chem., 293: 15524-15537, 2018. 4. Hirata K, Takakura Y, Shibasaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano T, Yamaguchi N, Yamaguchi N-t. FOXA1 confers resistance to TGF-beta-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation. J. Cell. Biochem., 2018 Sep 11. doi: 10.1002/jcb.27551. 5. Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N. Role of membrane cholesterol levels in activation of Lyn upon cell detachment. Int. J. Mol. Sci., 19: 1811, 2018. 6. Fukumoto Y, Takahashi K, Suzuki N, Ogra Y, Nakayama Y, Yamaguchi N. Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17. Biochem. Biophys. Res. Commun., 504: 380-386, 2018. 7. Ifuji A, Kuga T, Nakayama Y. Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone. MethodsX, 5: 431-437, 2018. 8. Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N. v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling. Sci. Rep., 8:1063, 2018. doi: 10.1038/s41598-018-19599-1 2017年 1. Ifuji A, Kuga T, Kaibori Y, Saito Y, Nakayama Y. A novel immunofluorescence method to visualize microtubules in the antiparallel overlaps of microtubule-plus ends in the anaphase and telophase midzone. Exp. Cell Res., 360: 347-357, 2017. doi.org/10.1016/j.mex.2018.04.011 2. Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N. The truncated isoform of the receptor tyrosine kinase ALK generated by alternative transcription initiation (ALKATI) induces chromatin structural changes in the nucleus in a kinase activity-dependent manner. Biol. Pharm. Bull., 40: 1968-1975, 2017. 3. Fukumoto Y, Nakayama Y, Yamaguchi N. The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex. Biochem. Biophys. Res. Commun., 490: 1147-1153, 2017. 4. Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N. Enhancement of TGF-b-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP). Biochem. Biophys. Res. Commun., 490: 1045-1051, 2017. 5. Nakayama Y, Soeda S, Ikeuchi M, Kakae K, Yamaguchi N. Cytokinesis failure leading to chromosome instability in v-Src-induced oncogenesis. Int. J. Mol. Sci., 18: 811, 2017. doi:10.3390/ijms18040811 6. Mikami H, Saito Y, Okamoto N, Kakihana A, Kuga T, Nakayama Y. Requirement of Hsp105 in CoCl2-induced HIF-1a accumulation and transcriptional activation. Exp. Cell Res., 352: 225-233, 2017. 7. Yamaguchi N, Nakayama Y, Yamaguchi N. Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer-stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6. J. Biol. Chem., 292: 8136-8148, 2017. 8. Kakae K, Ikeuchi M, Kuga T, Saito Y, Yamaguchi N, Nakayama Y. v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells. Cell. Signal., 30: 19-29, 2017. doi.org/10.1016/j.cellsig.2016.11.014 9. Yamaguchi N, Shibasaki M, Yamada C, Anzai E, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N. Tyrosine phosphorylation of the pioneer transcription factor FoxA1 promotes activation of estrogen signaling. J. Cell. Biochem., 118: 1453-1461, 2017. 2016年 1. Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N. Protective role for lipid modifications of Src-family kinases against chromosome missegregation. Sci. Rep., 6:38751, 2016. doi: 10.1038/srep38751 2. Kumar R, Agrawal T, Khan NA, Nakayama Y, Medigeshi GR. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Sci. Rep., 6:30490, 2016. doi: 10.1038/srep30490. 3. Fukumoto Y, Ikeuchi M, Nakayama Y, Yamaguchi N. The KYxxL motif in Rad17 protein is essential for the interaction with the 9–1–1 complex. Biochem, Biophys. Res. Commun., 477: 982-987, 2016. 4. Ikeuchi M, Fukumoto Y, Honda T, Kuga T, Saito Y, Yamaguchi N, Nakayama Y. v-Src causes chromosome bridges in a caffeine-sensitive manner by generating DNA damage. Int. J. Mol. Sci., 17: 871, 2016. doi:10.3390/ijms17060871 5. Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, Saito Y, Koura M, Takeda Y, Matsuda J, Tomonaga T, Nakayama Y. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes. Sci. Rep., 6:26557, 2016. doi: 10.1038/srep26557. 6. Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, Takamori M, Yamagishi N, Kuga T, Hatayama T, Nakayama Y. Yeast two-hybrid and one-hybrid screenings identify regulators of hsp70 gene expression. J. Cell. Biochem., 117: 2109-2117, 2016. 7. Iwamoto E, Ueta N, Matsui Y, Kamijo K, Kuga T, Saito Y, Yamaguchi N, Nakayama Y. ERK plays a role in chromosome alignment and participates in M-phase progression. J. Cell. Biochem., 117: 1340-1351, 2016. 8. Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N. Fyn accelerates M phase progression by promoting the assembly of mitotic spindle microtubules. J. Cell. Biochem., 117: 894-903, 2016. 9. Miura T, Fukumoto Y, Kubota S, Morii M, Honda T, Yamaguchi N, Nakayama Y, Yamaguchi N. Src family kinases maintain the balance between replication stress and the replication checkpoint. Cell Biol. Int., 40: 16-26, 2016 2015年 1. Morii M, Fukumoto Y, Kubota S, Yamaguchi N, Nakayama Y, Yamaguchi N. Imatinib inhibits inactivation of the ATM/ATR signaling pathway and recovery from adriamycin/doxorubicin-induced DNA damage checkpoint arrest. Cell Biol. Int., 39: 923-932, 2015 2014年 1. Morinaga T, Abe K, Nakayama Y, Yamaguchi N, Yamaguchi N. Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment. J. Biol. Chem., 289: 26327-26343, 2014 2. Fukumoto Y, Kuki K, Morii M, Miura T, Honda T, Ishibashi K, Hasegawa H, Kubota S, Ide Y, Yamaguchi N, Nakayama Y, Yamaguchi N. Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks. Biochem. Biophys. Res. Commun., 452: 542-547, 2014 3. Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Kuga T, Yamagishi N, Hatayama T, Nakayama Y. Nmi interacts with Hsp105beta and enhances the Hsp105beta-mediated Hsp70 expression. Exp. Cell Res., 327: 163-170, 2014 4. Fukumoto Y, Miura T, Morii M, Kubota S, Honda T, Kubota S, Morinaga T, Yamaguchi N, Nakayama Y, Yamaguchi N. v-Src inhibits the interaction between Rad17 and Rad9 and induces replication fork collapse. Biochem. Biophys. Res. Commun., 450: 885-890, 2014 5. Yamagishi N, Nakaoka R, Kondo R, Nishituji M, Saito Y, Kuga T, Hatayama T, Nakayama Y. Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein. Biochem. Biophys. Res. Commun., 448: 430-436, 2014 6. FukumotoY, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, Okamoto A, Yamaguchi N, Iwama A, Nakayama Y, Yamaguchi N. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J. Biol. Chem., 289: 12313-12329, 2014. 7. Kuga T, Nie H, Kazami T, Satoh M, Matsushita K, Nomura F, Maeshima K, Nakayama Y, Tomonaga T. Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. Oncogenesis, 3: e94, 2014. 8. Nakayama Y, Saito Y, Soeda S, Iwamoto E, Ogawa S, Yamagishi N, Kuga T and Yamaguchi N. Genistein induces cytokinesis failure through RhoA delocalization and anaphase chromosome bridging. J. Cell. Biochem., 115: 763-771, 2014. 9. Kubota S, Fukumoto Y, Ishibasi K, Soeda S, Kubota S, Yuki R, Nakayama Y, Aoyama K, Yamaguchi N, Yamaguchi N. Activation of the pre-replication complex is blocked by mimosine through reactive oxygen species-activated ATM without DNA damage. J. Biol. Chem., 289: 5730-5746, 2014. 2013年 1. Soeda S, Nakayama Y, Honda T, Aoki A, Tamura N, Abe K, Fukumoto Y and Yamaguchi N. v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure. Experimental Cell Research, 319: 1382-1397, 2013. 2. Nakayama Y and Yamaguchi N. Role of cyclin B1 levels in DNA damage and DNA damage-induced senescence. International Review of Cell and Molecular Biology, 305: 303-337, 2013. 3. Ishibashi K, Fukumoto Y, Hasegawa H, Abe K, Kubota S, Aoyama K, Kubota S, Nakayama Y and Yamaguchi N. Nuclear ErbB4 signaling through H3K9me3 that is antagonized by EGFR-activated c-Src. Journal of Cell Science, 126: 625-637, 2013. 4. Aoyama K, Yuki R, Horiike Y, Kubota S, Yamaguchi N, Morii M, Ishibashi K, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T and Yamaguchi N. Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase. Experimental Cell Research, 319: 3251-3268, 2013. 2012年 1. Nakayama Y, Matsui Y, Takeda Y, Okamoto M, Abe K, Fukumoto Y and Yamaguchi N. c-Src but not Fyn promotes proper spindle orientation in early prometaphase. The Journal of Biological Chemistry, 287: 24905-24915, 2012. 2. Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y and Yamaguchi N. Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: A novel method suitable for examining dynamic changes in proteins during mitotic progression. European Journal of Cell Biology, 91: 413-419, 2012. 3. Yamagishi N, Magara S, Tamura S, Saito Y and Hatayama T. Endoplasmic reticulum chaperone GRP78 suppresses the aggregation of proteins containing expanded polyglutamine tract. Biochemical and Biophysical Research Communications, 422: 522-533, 2012. 4. Yamagishi N, Ueda T, Mori A, Saito Y and Hatayama T. Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice. Biochemical and Biophysical Research Communications, 417: 364-370, 2012. 5. Hatayama T, Yamagishi N and Saito Y. Structure and function of HSP105 family proteins. Seikagaku, 84: 249-260, 2012. 2011年 1. Aoyama K, Fukumoto Y, Ishibashi K, Kubota S, Morinaga T, Horiike Y, Yuki R, Takahashi A, Nakayama Y and Yamaguchi N. Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. Experimental Cell Research, 317: 2874-2903, 2011 2. Uchida M, Ishii I, Hirata K, Yamamoto F, Tashiro K, Suzuki T, Nakayama Y, Ariyoshi N and Kitada M. Degradation of filamin induces contraction of vascular smooth muscle cells in Type-I collagen matrix honeycombs. Cellular Physiology and Biochemistry, 27: 669-680, 2011 3. Yamagishi N, Yokota M, Yasuda K, Saito Y, Nagata K and Hatayama T. Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells. Biochemical and Biophysical Research Communications, 409: 90-95, 2011. 2010年 1. Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N and Yamaguchi N. The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. Journal of Cell Science, 123: 2649-2662, 2010 2. Kikuchi I, Nakayama Y (corresponding author), Morinaga T, Fukumoto Y and Yamaguchi N. A decrease in cyclin B1 levels leads to polyploidization in DNA-damage induced senescence. Cell Biology International, 34: 645-653, 2010 3. Fukumoto Y, Obata Y, Ishibashi K, Tamura N, Kikuchi I, Aoyama K, Hattori Y, Tsuda K, Nakayama Y and Yamaguchi N. Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine. Cytotechnology, 62: 73-82, 2010 4. Yamagishi N, Goto K, Nakagawa S, Saito Y and Hatayama T. Hsp105 reduces the protein aggregation and cytotoxicity by expanded- polyglutamine proteins through the induction of Hsp70. Experimental Cell Research, 316: 2424-2433, 2010. 2009年 1. Nakayama Y, Shivas JM, Poole DS, Squirrell JM, Kulkoski JM, Schleede JB and Skop AR. Dynamin participates in the maintenance of anterior polarity in the C. elegans embryo. Developmental Cell, 16: 889-900, 2009. 2. Nakayama Y (corresponding author), Igarashi A, Kikuchi I, Obata Y, Fukumoto Y and Yamaguchi N. Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway. Experimental Cell Research, 315: 2515-2528, 2009. 3. Ikeda K, Nakayama Y, Ishii M, Obata Y, Kasahara K, Fukumoto Y and Yamaguchi N. Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes. Biochimica et Biophysica Acta, 1790: 1345-1352, 2009. 4. Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T and Yamaguchi N. Differential trafficking of c-Src, Lyn, c-Yes, and Fyn is specified by the state of palmitoylation in the SH4 domain. Journal of Cell Science, 122: 965-975, 2009. 5. Takahashi A, Obata Y, Fukumoto Y, Nakayama Y, Kasahara K, Kuga T, Higashiyama Y, Saito T, Yokoyama KK and Yamaguchi N. Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Experimental Cell Research, 315: 1117-1141, 2009. 6. Higashiyama Y, Takahashi A, Fukumoto Y, Nakayama Y and Yamaguchi N. Induction of chromatin condensation by nuclear expression of a novel arginine-rich cationic protein genetically engineered from the enhanced green fluorescent protein. Cytotechnology, 60: 153-159, 2009 7. Yamagishi N, Fujii H, Saito Y and Hatayama T. Hsp105β upregulates hsp70 gene expression through signal transducer and activator of transcription-3. The FEBS Journal, 276: 5870-5880, 2009. 8. Saito Y, Yamagishi N and Hatayama T. Nuclear localization mechanism of Hsp105β and its possible function in mammalian cells. The Journal of Biochemistry, 145: 185-191, 2009. 2008年 1. Ikeda K, Nakayama Y, Togashi Y, Obata Y, Kuga T, Kasahara K, Fukumoto Y and Yamaguchi N. Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. Experimental Cell Research, 314: 3392-3404, 2008. 2. Kasahara K, Nakayama Y and Yamaguchi N. v-Src and c-Src, nonpalmitoylated Src-family kinases, induce perinuclear accumulation of lysosomes through Rab7 in a kinase activity-independent manner. Cancer Letters, 262: 19-27, 2008. 3. Kuga T, Hoshino M, Nakayama Y, Kasahara K, Ikeda K, Obata Y, Takahashi A, Higashiyama Y, Fukumoto Y and Yamaguchi N. Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface. Experimental Cell Research, 314: 2040-2054, 2008. 4. Aoyama J, Akazawa Y, Kasahara K, Higashiyama Y, Kikuchi I, Fukumoto Y, Saburi S, Nakayama Y, Fukuda M and Yamaguchi N. Nuclear localization of magphinins, alternative splicing products of the human trophinin gene. Journal of Cellular Biochemistry, 103: 765-777, 2008. 5. Yamagishi N, Saito Y and Hatayama T. Mammalian 105 kDa heat shock family proteins suppress hydrogen peroxide-induced apoptosis through a p38 MAPK-dependent mitochondrial pathway in HeLa cells. The FEBS Journal, 275: 4558-4570, 2008. 2007年 1. Kuga T, Nakayama Y, Iwamatsu A, Fukumoto Y, Yokomori K and Yamaguchi N. Separation of a disulfide-linked phosphoprotein by diagonal SDS-PAGE with optimized gel crosslinking. Analytical Biochemistry, 370: 252-254, 2007. 2. Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y and Yamaguchi N. Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes. Experimental Cell Research, 313: 2651-2666, 2007. 3. Kasahara K, Nakayama Y, Nakazato Y, Ikeda K, Kuga T and Yamaguchi N. Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody. The Journal of Biological Chemistry, 282: 5327-5339, 2007. 4. Kasahara K, Nakayama Y, Sato I, Ikeda K, Hoshino M, Endo T and Yamaguchi N. Role of Src-family kinases in formation and trafficking of macropinosomes. Journal of Cellular Physiology, 211: 220-232, 2007. 5. Kuga T, Nakayama Y, Hoshino M, Higashiyama Y, Obata Y, Matsuda D, Kasahara K, Fukumoto Y and Yamaguchi N. Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells. Archives of Biochemistry and Biophysics, 466: 116-124, 2007. 6. Yamagishi N, Ishihara K, Saito Y and Hatayama T. The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate. Biochemical and Biophysical Research Communications, 350: 131-137, 2006. 7. Yamagishi N, Ishihara K, Saito Y and Hatayama T. Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax. Biochemical and Biophysical Research Communications, 350: 131-137, 2006.

2024年

1. Yanagida S, Yuki R, Saito Y, Nakayama Y.

LAT1 supports mitotic progression through Golgi unlinking in an amino acid transport activity-independent manner.

J. Biol. Chem., 300: 107761, 2024.

2. Yuki R, Kuwajima H, Ota R, Ikeda Y, Saito Y, Nakayama Y.

Eph signal inhibition potentiates the growth-inhibitory effects of PLK1 inhibition toward cancer cells.

Eur. J. Pharmacol., 963: 176229, 2024.

3. Tanaka J, Kuwajima H, Yuki R, Nakayama Y.

Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases.

Cell. Signal., 119: 111172, 2024

4. Kitagawa T, Matsumoto T, Ohta T, Yoshida T, Saito Y, Nakayama Y, Hadate Y, Ashihara E, Watanabe T.

Linderapyrone analogue LPD‐01 as a cancer treatment agent by targeting importin7.

J. Nat. Med., 2024. https://doi.org/10.1007/s11418-023-01774-y

2023年

1. Ota R, Watanabe T, Wazawa Y, Kuwajima H, Honda T, Soeda S, Saito Y, Yuki R, Fukumoto Y, Yamaguchi N-t, Yamaguchi N, Nakayama Y.

v-Src delocalizes Aurora B by suppressing Aurora B kinase activity during monopolar cytokinesis.

Cell. Signal. 109: 110764, 2023. https://doi.org/10.1016/j.cellsig.2023.110764

2. Ota S, Tanaka Y, Yasutake R, Ikeda Y, Yuki R, Nakayama Y, Saito Y.

Distinct effects of heat shock temperatures on mitotic progression by influencing the spindle assembly checkpoint.

Exp. Cell Res., 429: 113672, 2023. https://doi.org/10.1016/j.yexcr.2023.113672

3. Yuki R, Ikeda Y, Yasutake R, Saito Y, Nakayama Y.

SH2D4A promotes centrosome maturation to support spindle microtubule formation and mitotic progression.

Sci. Rep., 13: 2067, 2023. DOI: 10.1038/s41598-023-29362-w

4. Hasegawa N, Hongo M, Okada M, Kuga T, Abe Y, Adachi J, Tomonaga T, Yamaguchi N, Nakayama Y.

Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis.

Exp. Cell Res., 432: 113783, 2023.

5. Fukumoto Y, Hoshino T, Nakayama Y, Ogra Y.

The C-terminal tail of Rad17, iVERGE, binds the 9-1-1 complex independently of AAA+ ATPase domains to provide another clamploader interface.

DNA Repair, 130: 103567, 2023.

6. Matsumoto T, Ohnishi E, Kitagawa T, Okayama M, Saito Y, Yoshikawa H, Ohta T, Yoshida T, Nakayama Y, Watanabe T.

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell.

Genes Environ., 45: 5, 2023.

2022年

1. Fukumoto Y, Ikeuchi M, Nakayama Y, Ogra Y.

Rad17 translocates to nucleolus upon UV irradiation through nucleolar localization signal in the central basic domain.

Int. J. Mol. Sci., 23: 12300, 2022.

2021年

1. Ikeuchi M, Yuki R, Saito Y, Nakayama Y.

The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.

FASEB J, 35: e21242, 2021. DOI: 10.1096/fj.202001909R

2. Yuki R, Hagino M, Ueno S, Kuga T, Saito Y, Fukumoto Y, Yamaguchi N, Yamaguchi N, Nakayama Y.

The tyrosine kinase v-Src modifies cytotoxicities of anticancer drugs targeting cell division

J. Cell. Mol. Med., 25: 1677–1687, 2021. DOI: 10.1111/jcmm.16270

3. Morii M, Kubota S, Hasegawa C, Takeda Y, Kometani S, Enomoto K, Suzuki T, Yanase S, Sato R, Akatsu A, Hirata K, Honda T, Kuga T, Tomonaga T, Nakayama Y, Yamaguchi N-t, Yamaguchi N.

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle

Sci. Rep., 11: 2616, 2021. doi.org/10.1038/s41598-021-82189-1

4. Ikeda Y, Yasutake R, Yuki R, Saito Y, Nakayama Y.

Combination treatment of OSI-906 with Aurora B inhibitor reduces cell viability via cyclin B1 degradation–induced mitotic slippage.

Int. J. Mol. Sci., 22: 5706, 2021. https://doi.org/10.3390/ijms22115706

5. Fukumoto Y, Ikeuchi M, Qu L, Hoshino T, Yamaguchi N, Nakayama Y, Ogra Y.

Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes.

J. Biol. Chem., 297: 100831, 2021

6. Matsumoto T, Kitagawa T, Imahori D, Matsuzaki A, Saito Y, Ohta T, Yoshida T, Nakayama Y, Ashihara E, Watanabe T.

Linderapyrone: A Wnt signal inhibitor isolated from Lindera umbellata.

Bioorg. Med. Chem. Lett., 45: 128161, 2021

7. Imahori D, Matsumoto T, Saito Y, Ohta T, Yoshida T, Nakayama Y, Watanabe T.

Cell death-inducing activities via P-glycoprotein inhibition of the constituents isolated from fruits of Nandina domestica.

Fitoterapia, 154: 105023, 2021.

8. Teshima H, Watanabe H, Yasutake R, Ikeda Y, Yonezu Y, Okamoto N, Kakihana A, Yuki R, Nakayama Y, Saito Y.

Functional differences between Hsp105/110 family proteins in cell proliferation, cell division, and drug sensitivity.

J. Cell. Biochem., 122: 1958-1967, 2021.

2020年

1. Kaibori Y, Katayama K, Tanaka Y, Ikeuchi M, Ogawa M, Ikeda Y, Yuki R, Saito Y, Nakayama Y.

Kinase activity-independent role of EphA2 in the regulation of M-phase progression

Exp. Cell Res., 395: 112207, 2020. doi.org/10.1016/j.yexcr.2020.112207

2. Matsumoto T, Imahori D, Saito Y, Zhang W, Ohta T, Yoshida T, Nakayama Y, Ashihara E, Watanabe T.

Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells

J. Nat. Med., 74: 689–701, 2020. doi.org/10.1007/s11418-020-01420-x

3. Munira S, Yuki R, Saito Y, Nakayama Y.

ALK inhibitors-induced M phase delay contributes to the suppression of cell proliferation.

Cancers, 12: 1054, 2020. doi.org/10.3390/cancers12041054

　＊Faculty Opinions (旧: F1000Prime）で紹介されました。

4. 中山祐治.

受容体型チロシンキナーゼによる細胞分裂制御.

生化学, 92: 253–258, 2020.

doi: 10.14952/SEIKAGAKU.2020.920253

5. Matsumoto T, Imahori D, Achiwa K, Saito Y, Ohta T, Yoshida T, Kojima N, Yamashita M, Nakayama Y, Watanabe T.

Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus.

Fitoterapia, 142: 104524, 2020. doi.org/10.1016/j.fitote.2020.104524

6. Yamagishi A, Ikeda Y, Ikeuchi M, Yuki R, Saito Y, Nakayama Y.

Targeting insulin-like growth factor 1 receptor delays M-phase progression and synergizes with Aurora B inhibition to suppress cell proliferation.

Int. J. Mol. Sci., 21: 1058, 2020. doi.org/10.3390/ijms21031058

2019年

1.Fukumoto Y, Nakayama Y, Yamaguchi N.

Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1 δ/ε and CK2 to promote interaction with the 9-1-1 complex.

Biochem. Biophys. Res. Commun., 517: 310-316, 2019.

2. Yamane T, Saito Y, Teshima H, Hagino M, Kakihana A, Sato S, Shimada M, Kato Y, Kuga T, Yamagishi N, Nakayama Y.

Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation.

J. Cell. Biochem., 120: 17951-17962, 2019.

3. Matozaki M, Saito Y, Yasutake R, Munira S, Kaibori Y, Yukawa A, Tada M, Nakayama Y.

Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance.

Exp. Cell Res., 377: 67-74, 2019.

4. Kaibori Y, Saito Y, Nakayama Y.

EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M phase progression via maintenance of cortical rigidity.

FASEB J, 33: 5334-5349, 2019.

5. Kakihana A, Oto Y, Saito Y, Nakayama Y.

Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint.

FASEB J, 33: 3936-3953, 2019.

2018年

1. Saito Y, Nakayama Y.

2018. Mammalian heat shock protein Hsp105: The Hsp70 inducer and a potent target for cancer therapy.

In: A. A. A. Asea, P. Kaur (eds.): HSP70 in human diseases and disorders, Heat shock proteins 14, Springer Nature. 347-359.

2. Okumura D, Hagino M, Yamagishi A, Kaibori Y, Munira S, Saito Y, Nakayama Y.

Inhibitors of the VEGF receptor suppress HeLa S3 cell proliferation via misalignment of chromosomes and rotation of the mitotic spindle causing a delay in M-phase progression.

Int. J. Mol. Sci., 19: 4014, 2018. doi:10.3390/ijms19124014

3. Horiuchi M, Kuga T, Saito Y, Nagano M, Adachi J, Tomonaga T, Yamaguchi N, Nakayama Y.

The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1.

J. Biol. Chem., 293: 15524-15537, 2018.

4. Hirata K, Takakura Y, Shibasaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano T, Yamaguchi N, Yamaguchi N-t.

FOXA1 confers resistance to TGF-beta-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.

J. Cell. Biochem., 2018 Sep 11. doi: 10.1002/jcb.27551.

5. Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N.

Role of membrane cholesterol levels in activation of Lyn upon cell detachment.

Int. J. Mol. Sci., 19: 1811, 2018.

6. Fukumoto Y, Takahashi K, Suzuki N, Ogra Y, Nakayama Y, Yamaguchi N.

Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17.

Biochem. Biophys. Res. Commun., 504: 380-386, 2018.

7. Ifuji A, Kuga T, Nakayama Y.

Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone.

MethodsX, 5: 431-437, 2018.

8. Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N.

v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.

Sci. Rep., 8:1063, 2018. doi: 10.1038/s41598-018-19599-1

2017年

1. Ifuji A, Kuga T, Kaibori Y, Saito Y, Nakayama Y.

A novel immunofluorescence method to visualize microtubules in the antiparallel overlaps of microtubule-plus ends in the anaphase and telophase midzone.

Exp. Cell Res., 360: 347-357, 2017. doi.org/10.1016/j.mex.2018.04.011

2. Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N.

The truncated isoform of the receptor tyrosine kinase ALK generated by alternative transcription initiation (ALKATI) induces chromatin structural changes in the nucleus in a kinase activity-dependent manner.

Biol. Pharm. Bull., 40: 1968-1975, 2017.

3. Fukumoto Y, Nakayama Y, Yamaguchi N.

The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex.

Biochem. Biophys. Res. Commun., 490: 1147-1153, 2017.

4. Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N.

Enhancement of TGF-b-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).

Biochem. Biophys. Res. Commun., 490: 1045-1051, 2017.

5. Nakayama Y, Soeda S, Ikeuchi M, Kakae K, Yamaguchi N.

Cytokinesis failure leading to chromosome instability in v-Src-induced oncogenesis.

Int. J. Mol. Sci., 18: 811, 2017. doi:10.3390/ijms18040811

6. Mikami H, Saito Y, Okamoto N, Kakihana A, Kuga T, Nakayama Y.

Requirement of Hsp105 in CoCl2-induced HIF-1a accumulation and transcriptional activation.

Exp. Cell Res., 352: 225-233, 2017.

7. Yamaguchi N, Nakayama Y, Yamaguchi N.

Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer-stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.

J. Biol. Chem., 292: 8136-8148, 2017.

8. Kakae K, Ikeuchi M, Kuga T, Saito Y, Yamaguchi N, Nakayama Y.

v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells.

Cell. Signal., 30: 19-29, 2017. doi.org/10.1016/j.cellsig.2016.11.014

9. Yamaguchi N, Shibasaki M, Yamada C, Anzai E, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N.

Tyrosine phosphorylation of the pioneer transcription factor FoxA1 promotes activation of estrogen signaling.

J. Cell. Biochem., 118: 1453-1461, 2017.

2016年

1. Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N.

Protective role for lipid modifications of Src-family kinases against chromosome missegregation.

Sci. Rep., 6:38751, 2016. doi: 10.1038/srep38751

2. Kumar R, Agrawal T, Khan NA, Nakayama Y, Medigeshi GR.

Identification and characterization of the role of c-terminal Src kinase in dengue virus replication.

Sci. Rep., 6:30490, 2016. doi: 10.1038/srep30490.

3. Fukumoto Y, Ikeuchi M, Nakayama Y, Yamaguchi N.

The KYxxL motif in Rad17 protein is essential for the interaction with the

9–1–1 complex.

Biochem, Biophys. Res. Commun., 477: 982-987, 2016.

4. Ikeuchi M, Fukumoto Y, Honda T, Kuga T, Saito Y, Yamaguchi N, Nakayama Y.

v-Src causes chromosome bridges in a caffeine-sensitive manner by generating DNA damage.

Int. J. Mol. Sci., 17: 871, 2016. doi:10.3390/ijms17060871

5. Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, Saito Y, Koura M, Takeda Y, Matsuda J, Tomonaga T, Nakayama Y.

FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.

Sci. Rep., 6:26557, 2016. doi: 10.1038/srep26557.

6. Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, Takamori M, Yamagishi N, Kuga T, Hatayama T, Nakayama Y.

Yeast two-hybrid and one-hybrid screenings identify regulators of hsp70 gene expression.

J. Cell. Biochem., 117: 2109-2117, 2016.

7. Iwamoto E, Ueta N, Matsui Y, Kamijo K, Kuga T, Saito Y, Yamaguchi N, Nakayama Y.

ERK plays a role in chromosome alignment and participates in M-phase progression.

J. Cell. Biochem., 117: 1340-1351, 2016.

8. Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N.

Fyn accelerates M phase progression by promoting the assembly of mitotic spindle microtubules.

J. Cell. Biochem., 117: 894-903, 2016.

9. Miura T, Fukumoto Y, Kubota S, Morii M, Honda T, Yamaguchi N, Nakayama Y, Yamaguchi N.

Src family kinases maintain the balance between replication stress and the replication checkpoint.

Cell Biol. Int., 40: 16-26, 2016

2015年

1. Morii M, Fukumoto Y, Kubota S, Yamaguchi N, Nakayama Y,

Yamaguchi N.

Imatinib inhibits inactivation of the ATM/ATR signaling pathway and recovery from adriamycin/doxorubicin-induced DNA damage checkpoint arrest.

Cell Biol. Int., 39: 923-932, 2015

2014年

1. Morinaga T, Abe K, Nakayama Y, Yamaguchi N, Yamaguchi N.

Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment.

J. Biol. Chem., 289: 26327-26343, 2014

2. Fukumoto Y, Kuki K, Morii M, Miura T, Honda T, Ishibashi K, Hasegawa H, Kubota S, Ide Y, Yamaguchi N, Nakayama Y, Yamaguchi N.

Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.

Biochem. Biophys. Res. Commun., 452: 542-547, 2014

3. Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Kuga T, Yamagishi N, Hatayama T, Nakayama Y.

Nmi interacts with Hsp105beta and enhances the Hsp105beta-mediated Hsp70 expression.

Exp. Cell Res., 327: 163-170, 2014

4. Fukumoto Y, Miura T, Morii M, Kubota S, Honda T, Kubota S, Morinaga T, Yamaguchi N, Nakayama Y, Yamaguchi N.

v-Src inhibits the interaction between Rad17 and Rad9 and induces replication fork collapse.

Biochem. Biophys. Res. Commun., 450: 885-890, 2014

5. Yamagishi N, Nakaoka R, Kondo R, Nishituji M, Saito Y, Kuga T, Hatayama T, Nakayama Y.

Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein.

Biochem. Biophys. Res. Commun., 448: 430-436, 2014

6. FukumotoY, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, Okamoto A, Yamaguchi N, Iwama A, Nakayama Y, Yamaguchi N.

Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint.

J. Biol. Chem., 289: 12313-12329, 2014.

7. Kuga T, Nie H, Kazami T, Satoh M, Matsushita K, Nomura F, Maeshima K, Nakayama Y, Tomonaga T.

Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation.

Oncogenesis, 3: e94, 2014.

8. Nakayama Y, Saito Y, Soeda S, Iwamoto E, Ogawa S, Yamagishi N, Kuga T and Yamaguchi N.

Genistein induces cytokinesis failure through RhoA delocalization and anaphase chromosome bridging.

J. Cell. Biochem., 115: 763-771, 2014.

9. Kubota S, Fukumoto Y, Ishibasi K, Soeda S, Kubota S, Yuki R, Nakayama Y, Aoyama K, Yamaguchi N, Yamaguchi N.

Activation of the pre-replication complex is blocked by mimosine through reactive oxygen species-activated ATM without DNA damage.

J. Biol. Chem., 289: 5730-5746, 2014.

2013年

1. Soeda S, Nakayama Y, Honda T, Aoki A, Tamura N, Abe K, Fukumoto Y and Yamaguchi N.

v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure.

Experimental Cell Research, 319: 1382-1397, 2013.

2. Nakayama Y and Yamaguchi N.

Role of cyclin B1 levels in DNA damage and DNA damage-induced senescence.

International Review of Cell and Molecular Biology, 305: 303-337, 2013.

3. Ishibashi K, Fukumoto Y, Hasegawa H, Abe K, Kubota S, Aoyama K, Kubota S, Nakayama Y and Yamaguchi N.

Nuclear ErbB4 signaling through H3K9me3 that is antagonized by EGFR-activated c-Src.

Journal of Cell Science, 126: 625-637, 2013.

4. Aoyama K, Yuki R, Horiike Y, Kubota S, Yamaguchi N, Morii M, Ishibashi K, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T and Yamaguchi N.

Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase.

Experimental Cell Research, 319: 3251-3268, 2013.

2012年

1. Nakayama Y, Matsui Y, Takeda Y, Okamoto M, Abe K, Fukumoto Y and Yamaguchi N.

c-Src but not Fyn promotes proper spindle orientation in early prometaphase.

The Journal of Biological Chemistry, 287: 24905-24915, 2012.

2. Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y and Yamaguchi N.

Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: A novel method suitable for examining dynamic changes in proteins during mitotic progression.

European Journal of Cell Biology, 91: 413-419, 2012.

3. Yamagishi N, Magara S, Tamura S, Saito Y and Hatayama T.

Endoplasmic reticulum chaperone GRP78 suppresses the aggregation of proteins containing expanded polyglutamine tract.

Biochemical and Biophysical Research Communications, 422: 522-533, 2012.

4. Yamagishi N, Ueda T, Mori A, Saito Y and Hatayama T.

Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice.

Biochemical and Biophysical Research Communications, 417: 364-370, 2012.

5. Hatayama T, Yamagishi N and Saito Y.

Structure and function of HSP105 family proteins.

Seikagaku, 84: 249-260, 2012.

2011年

1. Aoyama K, Fukumoto Y, Ishibashi K, Kubota S, Morinaga T, Horiike Y, Yuki R, Takahashi A, Nakayama Y and Yamaguchi N.

Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation.

Experimental Cell Research, 317: 2874-2903, 2011

2. Uchida M, Ishii I, Hirata K, Yamamoto F, Tashiro K, Suzuki T, Nakayama Y, Ariyoshi N and Kitada M.

Degradation of filamin induces contraction of vascular smooth muscle cells in Type-I collagen matrix honeycombs.

Cellular Physiology and Biochemistry, 27: 669-680, 2011

3. Yamagishi N, Yokota M, Yasuda K, Saito Y, Nagata K and Hatayama T.

Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells.

Biochemical and Biophysical Research Communications, 409: 90-95, 2011.

2010年

1. Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N and Yamaguchi N.

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.

Journal of Cell Science, 123: 2649-2662, 2010

2. Kikuchi I, Nakayama Y (corresponding author), Morinaga T, Fukumoto Y and Yamaguchi N.

A decrease in cyclin B1 levels leads to polyploidization in DNA-damage induced senescence.

Cell Biology International, 34: 645-653, 2010

3. Fukumoto Y, Obata Y, Ishibashi K, Tamura N, Kikuchi I, Aoyama K, Hattori Y, Tsuda K, Nakayama Y and Yamaguchi N.

Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine.

Cytotechnology, 62: 73-82, 2010

4. Yamagishi N, Goto K, Nakagawa S, Saito Y and Hatayama T.

Hsp105 reduces the protein aggregation and cytotoxicity by expanded- polyglutamine proteins through the induction of Hsp70.

Experimental Cell Research, 316: 2424-2433, 2010.

2009年

1. Nakayama Y, Shivas JM, Poole DS, Squirrell JM, Kulkoski JM, Schleede JB and Skop AR.

Dynamin participates in the maintenance of anterior polarity in the C. elegans embryo.

Developmental Cell, 16: 889-900, 2009.

2. Nakayama Y (corresponding author), Igarashi A, Kikuchi I, Obata Y, Fukumoto Y and Yamaguchi N.

Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.

Experimental Cell Research, 315: 2515-2528, 2009.

3. Ikeda K, Nakayama Y, Ishii M, Obata Y, Kasahara K, Fukumoto Y and Yamaguchi N.

Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes.

Biochimica et Biophysica Acta, 1790: 1345-1352, 2009.

4. Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T and Yamaguchi N.

Differential trafficking of c-Src, Lyn, c-Yes, and Fyn is specified by the state of palmitoylation in the SH4 domain.

Journal of Cell Science, 122: 965-975, 2009.

5. Takahashi A, Obata Y, Fukumoto Y, Nakayama Y, Kasahara K, Kuga T, Higashiyama Y, Saito T, Yokoyama KK and Yamaguchi N.

Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization.

Experimental Cell Research, 315: 1117-1141, 2009.

6. Higashiyama Y, Takahashi A, Fukumoto Y, Nakayama Y and Yamaguchi N.

Induction of chromatin condensation by nuclear expression of a novel arginine-rich cationic protein genetically engineered from the enhanced green fluorescent protein.

Cytotechnology, 60: 153-159, 2009

7. Yamagishi N, Fujii H, Saito Y and Hatayama T.

Hsp105β upregulates hsp70 gene expression through signal transducer and activator of transcription-3.

The FEBS Journal, 276: 5870-5880, 2009.

8. Saito Y, Yamagishi N and Hatayama T.

Nuclear localization mechanism of Hsp105β and its possible function in mammalian cells.

The Journal of Biochemistry, 145: 185-191, 2009.

2008年

1. Ikeda K, Nakayama Y, Togashi Y, Obata Y, Kuga T, Kasahara K, Fukumoto Y and Yamaguchi N.

Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity.

Experimental Cell Research, 314: 3392-3404, 2008.

2. Kasahara K, Nakayama Y and Yamaguchi N.

v-Src and c-Src, nonpalmitoylated Src-family kinases, induce perinuclear accumulation of lysosomes through Rab7 in a kinase activity-independent manner.

Cancer Letters, 262: 19-27, 2008.

3. Kuga T, Hoshino M, Nakayama Y, Kasahara K, Ikeda K, Obata Y, Takahashi A, Higashiyama Y, Fukumoto Y and Yamaguchi N.

Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface.

Experimental Cell Research, 314: 2040-2054, 2008.

4. Aoyama J, Akazawa Y, Kasahara K, Higashiyama Y, Kikuchi I, Fukumoto Y, Saburi S, Nakayama Y, Fukuda M and Yamaguchi N.

Nuclear localization of magphinins, alternative splicing products of the human trophinin gene.

Journal of Cellular Biochemistry, 103: 765-777, 2008.

5. Yamagishi N, Saito Y and Hatayama T.

Mammalian 105 kDa heat shock family proteins suppress hydrogen peroxide-induced apoptosis through a p38 MAPK-dependent mitochondrial pathway in HeLa cells.

The FEBS Journal, 275: 4558-4570, 2008.

2007年

1. Kuga T, Nakayama Y, Iwamatsu A, Fukumoto Y, Yokomori K and Yamaguchi N.

Separation of a disulfide-linked phosphoprotein by diagonal SDS-PAGE with optimized gel crosslinking.

Analytical Biochemistry, 370: 252-254, 2007.

2. Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y and Yamaguchi N.

Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.

Experimental Cell Research, 313: 2651-2666, 2007.

3. Kasahara K, Nakayama Y, Nakazato Y, Ikeda K, Kuga T and Yamaguchi N.

Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody.

The Journal of Biological Chemistry, 282: 5327-5339, 2007.

4. Kasahara K, Nakayama Y, Sato I, Ikeda K, Hoshino M, Endo T and Yamaguchi N.

Role of Src-family kinases in formation and trafficking of macropinosomes.

Journal of Cellular Physiology, 211: 220-232, 2007.

5. Kuga T, Nakayama Y, Hoshino M, Higashiyama Y, Obata Y, Matsuda D, Kasahara K, Fukumoto Y and Yamaguchi N.

Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells.

Archives of Biochemistry and Biophysics, 466: 116-124, 2007.

6. Yamagishi N, Ishihara K, Saito Y and Hatayama T.

The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate.

Biochemical and Biophysical Research Communications, 350: 131-137, 2006.

7. Yamagishi N, Ishihara K, Saito Y and Hatayama T.

Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax.

Biochemical and Biophysical Research Communications, 350: 131-137, 2006.