研究実績

2020年以降の研究実績はこちら

著　書

  1. 村西昌三：製剤学 (改訂第３版).　大塚昭信、池田　憲、村西昌三編：3-6 坐剤、6-1 内用剤からの吸収、6-9 病態時、年齢による薬物動態の変化、6-10 薬物相互作用.　南江堂　pp.159-164、pp.211-213、pp.285-287、pp.288-291 (1997).
  2. 山本　昌：製剤学 (改訂第３版).　大塚昭信、池田　憲、村西昌三編：7-2 ドラッグデリバリーシステム (DDS).　南江堂　pp.307-317 (1997).
  3. 山本　昌：改訂 図解 夢の薬剤DDS.　堀　了平監修、橋田　充編集：第３章　新しい投与経路、 吸収障壁の克服.　薬業時報社　pp.35-52 (1997).
  4. 山本　昌：実践模擬テスト～薬剤師国家試験～240問.　廣川書店　pp.81-92、pp.169-179 (1997).

論　文

  1. Takuya Fujita, Hidenori Yamada, Masaki Fukuzumi, Asuka Nishimaki, Akira Yamamoto, and Shozo Muranishi: Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. Life Sci. 60, 307-313 (1997).
  2. 奥村茂樹、高瀬佳要、田中秀明、新迫恵子、村上正裕、山本　昌、村西昌三：アフリカツメガエル摘出肺組織を用いた薬物の肺上皮細胞透過性評価 Drug Delivery System 12, 27-32 (1997).
  3. Takuya Fujita, Takashi Tamura, Hidenori Yamada, Akira Yamamoto, and Shozo Muranishi: Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against Sarcoma-180 bearing mice. J. Drug Targeting 4, 289-296 (1997).
  4. Hideyuki Tozaki, Yasuharu Emi, Eri Horisaka, Takuya Fujita, Akira Yamamoto, and Shozo Muranishi: Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat cecal contents: Implications in peptide delivery to the colon. J. Pharm. Pharmacol. 49, 164-168 (1997).
  5. Akeo Hagiwara, Chouhei Sakakura, Hiroyuki Tsujimoto, Tsutomu Imanishi, Masaharu Ohgaki, Junya Yamasaki, Kiyoshi Sawai, Toshio Takahashi, Takuya Fujita, Akira Yamamoto, Shozo Muranishi, and Yoshihito Ikada: Selective delivery of 5-fluorouracil (5-FU) to i.p. tissues using 5-FU microspheres in rats. Anti-Cancer Drugs 8, 182-188 (1997).
  6. Shozo Muranishi, Takuya Fujita, Akira Yamamoto, and Masahiro Murakami: Potential for lymphatic targeting of peptides. J. Controlled Rel. 46, 157-164 (1997).
  7. 山崎純也、萩原明於、高橋俊雄、村西昌三、筏　義人：5-FUマイクロスフェア腹腔内投与による癌性腹膜炎の治療 ― 齧歯類における検討 ― .Drug Delivery System, 12, 95-100 (1997).
  8. Tetsuo Sugiyama, Akira Yamamoto, Yoshiko Kawabe, Tomomi Uchiyama, Ying-Shu Quan, and Shozo Muranishi: Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by an in vitro Ussing chamber method: Correlation with an in situ absorption experiment. Biol. Pharm. Bull. 20, 812-814 (1997).
  9. Isao Sasaki, Takashi Tamura, Tomoko Shibakawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi: Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm. Res. 14, 1004-1007 (1997).
  10. Shigeki Okumura, Hideaki Tanaka, Keiko Shinsako, Mayuko Ito, Akira Yamamoto, and Shozo Muranishi: Evaluation of drug absorption after intrapulmonary administration using Xenopus pulmonary membranes: Correlation with in vivo pulmonary absorption studies in rats. Pharm. Res. 14, 1282-1285 (1997).
  11. Hideyuki Tozaki, Junta Komoike, Chika Tada, Takako Maruyama, Akira Terabe, Tsutomu Suzuki, Akira Yamamoto, and Shozo Muranishi: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. J. Pharm. Sci. 86, 1016-1021 (1997).
  12. Akira Yamamoto, Shigeki Okumura, Yoshimi Fukuda, Mayu Fukui, Kanae Takahashi, and Shozo Muranishi: Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats. J. Pharm. Sci. 86, 1144-1147 (1997).
  13. Akira Yamamoto, Taishi Okagawa, Atsushi Kotani, Tomomi Uchiyama, Takesada Shimura, Shigeru Tabata, Shuji Kondo, and Shozo Muranishi: Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes. J. Pharm. Pharmacol. 49, 1057-1061 (1997).
  14. Takuya Fujita, Yutaka Morishita, Hitomi Ito, Daisuke Kuribayashi, Akira Yamamoto, and Shozo Muranishi: Enhancement of the small intestinal uptake of phenylalanylglycine via a H+/oligopeptide transport system by chemical modification with fatty acids. Life Sci. 61, 2455-2465 (1997).
  15. Kenjiro Koga, Masahiro Murakami, and Susumu Kawashima: Contribution of hydrophobicity of nonionic detergents to membrane lipid fluidity and disopyramide uptake by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull. 20, 674-679 (1997).
  16. Tetsuo Sugiyama , Akira Yamamoto, Yoshiko Kawabe, Tomomi Uchiyama, Ying-Shu Quan, Shozo Muranishi. Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: Correlation with an in situ absorption experiment. Biol Pharm.Bull., 20, 812-814(1997)

総　説

  1. 村西昌三：ペプチド医薬品の腸管吸収改善を目的とした送達システムの設計.　薬学雑誌　117, 394-414 (1997).
  2. 東崎英之、山本　昌、村西昌三：キトサンカプセルを用いた生理活性ペプチドの大腸特異的送達法の開発.　Drug Delivery System, 12, 311-320 (1997).
  3. 山本　昌：生理活性ペプチドの経粘膜吸収改善に関する研究（平成８年度日本薬物動態学会奨励賞受賞論文）.　薬物動態, 12, 393-400 (1997).
  4. 山本　昌、村西昌三：消化管吸収の改善を目的としたペプチド性医薬品の脂肪酸修飾.　Drug Delivery System, 12, 381-395 (1997).
  5. Shozo Muranishi, and Akira Yamamoto: Rectal drug delivery systems - preface -. Adv. Drug Deliv. Rev., 28, 171 (1997).
  6. Akira Yamamoto, and Shozo Muranishi: Rectal drug delivery systems - Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification. Adv. Drug Deliv. Rev., 28, 275-299 (1997).

プロシーディングス

  1. 内山知実、小谷篤史、山本　昌、村西昌三：タンパク分解酵素阻害剤及び化学修飾によるエンケファリンの消化管粘膜透過性の改善.　薬剤学, 57(Suppl.), 50-51 (1997).
  2. 権　英淑、服部康二、山本　昌、村西昌三：Caco-2 培養細胞系を用いた各種促進剤の有効性及び安全性の評価.　薬剤学, 57(Suppl.), 52-53 (1997).
  3. 福澄正規、山田秀徳、藤田卓也、山本　昌、村西昌三：アニオン性薬物の消化管粘膜排出機構の検討. 薬剤学, 57(Suppl.), 54-55 (1997).
  4. 東崎英之、躍場朋和、村上正裕、山本　昌、村西昌三、萩野義昇、寺部　亮、鈴木　勉：キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的送達法の開発. 薬剤学, 57(Suppl.), 196-197 (1997).
  5. Ying-shu Quan, Koji Hattori, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. Proc. Int. Symp. Contrl. Rel. Bioact. Mater., 24, 343-344 (1997).
  6. Tomokazu Odoriba, Hideyuki Tozaki, Akira Yamamoto, Akira Terabe, Tsutomu Suzuki, and ShozoMuranishi: Colon delivery of anti-inflammatory drugs accelerates healing of TNBS induced-colitis in rats. Proc. Int. Symp. Contrl. Rel. Bioact. Mater., 24, 345-346 (1997).
  7. Daisuke Kuribayashi, Yuuko Nakamoto, Hisayo Kasama, Takuo Yoshida, Akira Yamamoto, and Shozo Muranishi: Effect of bacitracin on the transport of water soluble compounds across the intestinal membrane. Proc. Int. Symp. Contrl. Rel. Bioact. Mater., 24, 347-348 (1997).
  8. Akira Yamamoto, Masahiro Murakami, Atsushi Kotani, Tomomi Uchiyama, Takuya Fujita, and Shozo Muranishi: Enteric peptide delivery by chemical modification with fatty acids: Epithelial permeability enhancement of DADLE. Proc. Int. Symp. Contrl. Rel. Bioact. Mater., 24, 349-350 (1997).
  9. Soon-In Kim, Masaki Yamamoto, Hiroshi Terashima, Hideyuki Tozaki, Akira Yamamoto, Shozo Muranishi, and Yoshiharu Kimura: Improvement of oral bioavailability of insulin by colon targeting system using azopolymer. Proc. Int. Symp. Contrl. Rel. Bioact. Mater., 24, 377-378 (1997).
  10. Ying-shu Quan, Koji Hattori, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. CRS-CPA Joint Workshop on Recent Advances in Drug Delivery Science and Technology Abstruct Book. pp.P-9 - P-10 (1997).
  11. Ying-shu Quan, Koji Hattori, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. Proc. KSP CRS Joint Symp. pp.699-610 (1997).

解説、報告書等

  1. 山本　昌：消化管における薬物の能動的排出機構.　薬物動態, 12, 164-165 (1997).
  2. 山本　昌：シリーズ・基礎薬学 その８「排泄」. 日本薬剤師会雑誌, 49, 201-203 (1997).
  3. 村上正裕、村西昌三：糖尿病(２) インスリンDDS―非注射製剤開発―.　日本臨床, 55, 273-281 (1997).

学会発表

  1. 村西　昌三：ペプチド医薬品の腸管吸収改善を目的とした送達システムの設計. 日本薬学会第１１７年会 (東京), (1997) 3.
  2. 小谷敦史、内山知実、村上正裕、山本　昌、村西昌三：エンケファリン及びその誘導体の消化管吸収の改善（１）各種タンパク分解酵素阻害剤との併用.　日本薬学会第１１７年会 (東京), (1997) 3.
  3. 小谷敦史、内山知実、村上正裕、山本　昌、村西昌三、藤原洋一、木曽良明：エンケファリン及びその誘導体の消化管吸収の改善（２）DADLEの脂肪酸による化学修飾.　日本薬学会１１７年会 (東京), (1997) 3.
  4. 栗林大輔、中本優子、山本　昌、村西昌三：Bacitracinの吸収促進機構に関する検討.　日本薬学会第１１７年会 (東京), (1997) 3.
  5. 服部康二、権　英淑、辻内亜砂美、原　知栄子、山本　昌、村西昌三：Caco-2 培養細胞系を用いた各種吸収促進剤の有効性及び安全性の評価.　日本薬学会第１１７年会 (東京), (1997) 3.
  6. 渡辺利昌、奥村茂樹、亀村知都、田中秀明、新迫恵子、山本　昌、村西昌三：アフリカツメガエル肺組織を用いた生理活性ペプチドの透過性の検討 ～ In Situ 経肺吸収実験系ならびに In Vitro 肺上皮細胞系との相関 ～.　日本薬学会第１１７年会 (東京), (1997) 3.
  7. 山田秀徳、福澄正規、木村　豪、杉山真紀、藤田卓也、山本　昌、村西昌三：消化管粘膜からの有機アニオン分泌機構に関する検討.　日本薬学会第１１７年会 (東京), (1997) 3.
  8. 躍場朋和、東崎英之、渡辺　憲、多田由美、山本　昌、村西昌三：キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的発達法の開発.　日本薬学会第１１７年会 (東京), (1997) 3.
  9. 城之下賢、北岡健一、北森敦子、山本　昌、村西昌三：高分子薬物及び脂溶性薬物の経皮吸収改善に及ぼす超音波の影響.　日本薬学会第１１７年会 (東京), (1997) 3.
  10. 森田邦彦、小西廣己、山路　昭、杉山徹夫、山本　昌、村西昌三：ジゴキシン血中動態におよぼすフルコナゾールおよびスピロノラクトンの影響.　日本薬学会第１１７年会 (東京), (1997) 3.
  11. 内山知実、小谷篤史、山本　昌、村西昌三：タンパク分解酵素阻害剤及び化学修飾によるエンケファリンの消化管粘膜透過性の改善.　日本薬剤学会第１２年会 (埼玉), (1997) 4.
  12. 権　英淑、服部康二、山本　昌、村西昌三：Caco-2 培養細胞系を用いた各種促進剤の有効性及び安全性の評価.　日本薬剤学会第１２年会 (埼玉), (1997) 4.
  13. 福澄正規、山田秀徳、藤田卓也、山本　昌、村西昌三：アニオン性薬物の消化管粘膜排出機構の検討.日本薬剤学会第１２年会 (埼玉), (1997) 4.
  14. 東崎英之、躍場朋和、村上正裕、山本　昌、村西昌三、萩野義昇、寺部　亮、鈴木　：キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的送達法の開発.　日本薬剤学会第１２年会 (埼玉), (1997) 4.
  15. Akira Yamamoto, Hideyuki Tozaki, Shozo Muranishi, Akira Terabe, Takayuki Matsumoto, and Tsutomu Suzuki: Chitosan capsules for colon specific drug delivery: Improvement of insulin absorption from the rat colon. 2nd Int. Symp. on Polymer Therapeutics ( Kumamoto ), (1997) 4.
  16. Daisuke Kuribayashi, Yuuko Nakamoto, Hisayo Kasama, Takuo Yoshida, Akira Yamamoto, and Shozo Muranishi: Effect of Bacitracin on the transport of water soluble compounds across the intestinal membrane. 4th Int. Conference on Drug Absorption ( Edinburgh , Scotland ), (1997) 6.
  17. Akira Yamamoto, Masahiro Murakami, Tomomi Uchiyama, Atsushi Kotani, Takuya Fujita, and Shozo Muranishi: Enhanced intestinal permeability of DADLE, an enkephalin analogue, due to chemical modification with fatty acids. 4th Int. Conference on Drug Absorption ( Edinburgh , Scotland ), (1997) 6.
  18. Ying-shu Quan, Koji Hattori, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. 4th Int. Conference on Drug Absorption ( Edinburgh , Scotland ), (1997) 6.
  19. Soon-In Kim, Masaki Yamamoto, Hiroshi Terashima, Hideyuki Tozaki, Akira Yamamoto, Shozo Muranishi, and Yoshiharu Kimura: Improvement of oral bioavailability of insulin by colon targeting system using azopolymer. 4th Int. Conference on Drug Absorption ( Edinburgh , Scotland ), (1997) 6.
  20. Tomokazu Odoriba, Hideyuki Tozaki, Akira Yamamoto, Akira Terabe, Tsutomu Suzuki, and Shozo Muranishi: Colon delivery of anti-inflammatory drugs accelerates healing of TNBS induced-colitis in rats. 4th Int. Conference on Drug Absorption ( Edinburgh , Scotland ), (1997) 6.
  21. Ying-shu Quan, Ewa Lundborg, Koji Hattori, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. 24th Int. Symp. Contrl. Rel. Bioact. Mater ( Stockholm , Sweden ), (1997) 6.
  22. Tomokazu Odoriba, Hideyuki Tozaki, Akira Yamamoto, Akira Terabe, Tsutomu Suzuki, and Shozo Muranishi: Colon delivery of anti-inflammatory drugs accelerates healing of TNBS induced-colitis in rats. 24th Int. Symp. Contrl. Rel. Bioact. Mater. ( Stockholm , Sweden ), (1997) 6.
  23. Daisuke Kuribayashi, Yuuko Nakamoto, Hisayo Kasama, Takuo Yoshida, Akira Yamamoto, and Shozo Muranishi: Effect of bacitracin on the transport of water soluble compounds across the intestinal membrane. 24th Int. Symp. Contrl. Rel. Bioact. Mater. ( Stockholm , Sweden ), (1997) 6.
  24. Akira Yamamoto, Masahiro Murakami, Atsushi Kotani, Tomomi Uchiyama, Takuya Fujita, and Shozo Muranishi: Enteric peptide delivery by chemical modification with fatty acids: Epithelial permeability enhancement of DADLE. 24th Int. Symp. Contrl. Rel. Bioact. Mater. ( Stockholm , Sweden ), (1997) 6.
  25. Soon-In Kim, Masaki Yamamoto, Hiroshi Terashima, Hideyuki Tozaki, Akira Yamamoto, Shozo Muranishi, and Yoshiharu Kimura: Improvement of oral bioavailability of insulin by colon targeting system using azopolymer. 24th Int. Symp. Contrl. Rel. Bioact. Mater. ( Stockholm , Sweden ), (1997) 6.
  26. 村上正裕、内山知実、巽　浩幸、交川佳克、友田　寛、佐々木佳代子、山本　昌、村西昌三：消化管粘膜の薬物透過性に及ぼす吸収促進剤と内因性物質との作用の比較.　第１３回日本DDS学会 (札幌,(1997) 7.
  27. 小茂池潤太、東崎英之、西岡純子、山本　昌、村西昌三、金　淳二、寺島　宏：アゾポリマーコーティングペレットを用いた生理活性ペプチドの大腸特異的送達法の開発.　第１３回日本DDS学会 (札幌,(1997) 7.
  28. 東崎英之、躍場朋和、村上正裕、山本　昌、村西昌三、萩野義昇、寺部　亮、鈴木　：キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的送達法の開発.　第１３回日本DDS学会 (札幌), (1997) 7.
  29. Ying-shu Quan, Koji Hattori, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. CRS-CPA Joint Workshop on Recent Advances in Drug Delivery Science and Technology ( Beijng , China ), (1997) 9.
  30. Ying-shu Quan, Koji Hattori, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. KSP and CRS Joint Symposium on Recent Advances in Drug Delivery and Biomaterials ( Seoul , Korea ), (1997) 9.
  31. Akira Yamamoto: Enhancer approach to improve pulmonary drug absorption. Conference V Nasal and Pulmonary Drug Delivery ( Stockholm , Sweden ), (1997) 9.
  32. 東崎英之、躍場朋和、小茂池潤太、山本　昌、寺部　亮、鈴木　、村西昌三：キトサンカプセルを用いた生理活性ペプチド及び潰瘍性大腸炎治療薬の大腸特異的送達法の開発.　第１２回日本薬物動態学会年会 (名古屋), (1997) 11.
  33. 北岡健一、城之下　賢、北森敦子、本屋敷佳代子、山本　昌、村西昌三：超音波を用いた高分子薬物及び脂溶性薬物の経皮吸収改善に関する検討.　第１２回日本薬物動態学会年会 (名古屋), (1997) 11.
  34. 田中秀明、伊藤真由子、奥村茂樹、山本　昌、村西昌三：アフリカツメガエル肺組織を用いたインスリンの透過性に及ぼす各種添加剤の影響.　第１２回日本薬物動態学会年会 (名古屋), (1997) 11.
  35. 渡邊利昌、田中秀明、山下昌寛、杉本邦美、山本　昌、村西昌三：A-549 細胞系を用いた薬物の肺上皮細胞透過性の評価 ～ in vivo ラット経肺吸収実験系との相関 ～. 第１２回日本薬物動態学会年会 (名古屋), (1997) 11.
  36. 西岡純子、小茂池潤太、東崎英之、山本　昌、村西昌三、金　淳二、寺島　宏：アゾポリマーコーティングペレットを用いた生理活性ペプチドの大腸特異的送達法の開発.　第１２回日本薬物動態学会年会 (名古屋), (1997) 11.
  37. 村上正裕、巽　浩幸、交川佳克、今岡奈央、小幡英利、内山知実、山本　昌、村西昌三：吸収促進剤の腸管粘膜透過性亢進作用における inflammatory mediator の関与.　第１２回日本薬物動態学会年会 (名古屋), (1997) 11.