研究実績

2020年以降の研究実績はこちら

著　書

  1. 村西昌三：製剤学（改訂第2版）, 大塚昭信、池田　憲、村西昌三：第3章 各種剤形　3-6 坐剤. 第6章 適用後の問題　6-1 内用剤からの吸収. 南江堂, 170-174, 221-235, (1992).
  2. 山本　昌：製剤学（改訂第2版）, 大塚昭信、池田　憲、村西昌三：第7章 薬物の有用性の調節　7-2 ドラッグデリバリーシステム（DDS）. 南江堂, 319-329, (1992).
  3. Hiroshi Yoshikawa and Shozo Muranishi : Lymphatic transport of drugs, W.N. Charman and V.J.Stella : Chapter 7 :Lymphatic transport of polar drugs after gastrointestinal administration. CRC Press, 233-253, (1992).

論　文

  1. Masahiro Murakami, Yoko Kusanoi, Kanji Takada, and Shozo Muranishi : Assessment of enhancing ability of medium-chain alkyl saccharides as new absoption enhancers in rat rectum. Int. J. Pharm., 79, 159-169 (1992).
  2. Akeo Hagiwara, Toshio Takahashi, Kiyoshi Sawai, Kosuke Seiki, Michitoshi Ito, Shinji Okano, Chouhei, Sakakura, Satoshi Shobayashi, Shozo Muranishi, and Hiroshi Tomoda: Enhanced therapeutic efficacy of intralymphnodal etoposide on distal lymph node metastases using a new dosage format-activated carbon particles adsorbing etoposide. Anti-Cancer Drug Design , 7, 163-168 (1992).
  3. Masahiro Murakami, Kanji Takada, and Shozo Muranishi: Further mechanistic study on intestinal absorption enhanced by unsturated fatty acids : Reversible effect by sulfhydryl modification. Biochim. Biophys. Acta., 1117, 83-89 (1992).
  4. Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi: Transfer of exogeneous macromolecules from rat stomach wall to blood and lymph is dependent on molecular weight. Chem. Pharm. Bull., 40, 1277-1279 (1992).
  5. 友田　寛、田中友希夫、村上正裕、山本　昌、村西昌三：カプロイルリゾチームの合成とラットにお けるリンパ移行性の改善. Drug Delivery System., 7, 169-172 (1992).
  6. 天満丈裕、田島　繁、村上正裕、山本　昌、村西昌三：カプロン酸を用いた化学修飾によるテトラガストリンの消化管吸収の改善. Drug Delivery System., 7, 187-190 (1992).
  7. Akeo Hagiwara, Toshio Tkahashi, Akihiko Iwamoto, Chihiro Yoneyama, Michitoshi Ito, Tsunetoshi Sasabe, Shozo Muranishi, and Shoji Matsumoto: A new dosage form comprising a suspension of activated carbon particles adsorbing aclarubicin : Toxicity in mice. Anti-Cnacer Drugs, 2, 365-369 (1992).
  8. Minoru Hashizume, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, Kanji Takada, and Shozo Muranishi: Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats. J. Pharm. Pharmacol., 44, 555-559 (1992).
  9. Akeo Hagiwara, Toshio Takahashi, Tsunetoshi Sasabe, Michitoshi Ito, Masaki Lee, Chouhei Sakakura, Satoshi Shobayashi, Shozo Muranishi, and Shigeru Tajima: Toxicity of a new dosage format, cisplatin incorporated in lactic acid oligomer microspheres, in mice. Anti-Cancer Drugs, 3, 237-244 (1992).
  10. Keigo Yamada, Masahiro Murakami, Akira Yamamoto, Kanji Takada, and Shozo Muranishi: Improvement of intestinal absorption of thyrotropin-releasing hormone by chemical modification with lauric acid. J. Pharm. Pharmacol., 44, 717-721 (1992).
  11. Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi: Molecular weight-dependent lymphatic transfer of exogenous macromolecules from large imtestine of renal insufficiency rats. Pharm. Res., 9, 1195-1198 (1992).
  12. 萩原明於、高橋俊雄、伊藤通敏、阪倉長平、友田　寛、村西昌三：活性炭吸着エトポシド腹腔内投与による癌の大動脈周囲リンパ節転移の化学療法―マウスにおける検討―. Drug Delivery System., 7, 341-344 (1992).
  13. Akira Yamamoto, Eiji Hayakawa,Yasuki Kato, Akio Nishiura, and Vincent H. L. Lee: A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit. J. Pharmacol. Exp. Ther., 263, 25-31 (1992).
  14. Masaaki Masegi, Naomi Wakabayashi, Kazuyoshi Sagara, Yoshinori Teramura, Akira Yamamoto, Yoshinobu Takakura, Mitsura Hashida, Hitoshi Sezaki. Permeability of macromolecules in cultured endothelial and tumor cell layers on microporous membranes. Int. J. Pharm., 78, 103-113(1992).
  15. Eiji Hayakawa, Du-Shieng Chien, Kazuhiro Inagaki, Akira Yamamoto, Wei Wang, Vincent H.L Lee. Conjunctival penetration of insulin and peptide drugs in the albino rabbit. Pharm, Res.,9, 769-775(1992).

総　説

  1. 村西昌三：吸収改善のための化学修飾と吸収促進剤.　カレントテラピー, 10, 1021-1024 (1992).

プロシーディングス

  1. Masahiro Murakami and Shozo Muranishi : Enhancing mechanism of intestinal drug absorption produced by absorption enhancers. J. Pharmacobio-Dyn., 15, s-27 (1992).
  2. Akira Yamamoto, Keigo Yamada, Takehiro Tenma, Takayuki Douen, Yukio Tanaka, Yutaka Tomoda, Masahiro Murakami, and Shozo Muranishi : Improvement of intestinal absorption of peptides and proteins by chemical modification with fatty acids. J. Pharmacobio-Dyu., 15, s-28 (1992).
  3. Shozo Muranishi, Masahiro Murakami, Minoru Hashidzume, Keigo Yamada, Shigeru Tajima, and Yoshiaki Kiso : Trials of lipid modification of peptide hormones for intestinal delivery. J. Control. Release., 19, 179-188 (1992).
  4. Toshio Taniguchi, Yutaka Tomoda, Yukio Tanaka, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Synthesis of acyloyl lysozyme and improvement of its lymphatic transport following small intestinal administation in rats. Proc. 19th International Symposium on Controlled Release of Bioactive Materials, 104-105 (1992).
  5. Hiroyuki Asada, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Improvement of intestinal absorption of insulin by chemical modification with fatty acids. Proc. 19th International Symposium on Controlled Release of Bioactive Materials, 212-213 (1992).
  6. Hiroyuki Asada, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Improvement of intestinal absorption of insulin by chemical modification with fatty acids. Proc. 19th International Symposium on Controlled Release of Bioactive Materials, 212-213 (1992).
  7. Shozo Muranishi : Improvement of intestinal absorption of peptides by chemical modification with fatty acids. Peptides, Theoretical and Practical Approaches to their Therapy, 71-77 (1992).
  8. Akira Yamamoto : Transmucosal absoption of peptide drugs and its improvement. Peptides, Theoretical and practical approaches to their therapy, 87-93 (1992).

学会発表

  1. 岡川泰士、村上正裕、山本　昌、村西昌三、志村武貞、田端　滋、近藤修二：In Vitro Ussing Chamber を用いたEbiratide の消化管吸収性の評価ならびにその吸収改善.　日本薬学会第112年会（福岡）, (1992) 3.
  2. 天満丈裕、村上正裕、山本　昌、村西昌三：In Vitro Ussing Chamber を用いたカプロイルテトラガストリンの大腸粘膜透過性.　日本薬学会第112年会（福岡）, (1992) 3.
  3. 道円隆行、村上正裕、山本　昌、村西昌三：In Vitro Ussing Chamber を用いたアシロイルインスリンの消化管粘膜透過性.　日本薬学会第112年会（福岡）, (1992) 3.
  4. 田中浩一郎、村上正裕、山本　昌、村西昌三：In Vitro 反転腸管法を用いたLauroyl-TRH の消化管吸収機構に関する検討.　日本薬学会第112年会（福岡）, (1992) 3.
  5. 谷口寿生、友田　寛、田中友希夫、村上正裕、山本　昌、村西昌三：カプロイルリゾチームの消化管吸収に及ぼすエマルション剤形の影響.　日本薬学会第112年会（福岡）, (1992) 3.
  6. 高田浩一、村上正裕、山本　昌、村西昌三：シスプラチンのポリエチレングリコール化修飾による肺近傍らリンパ節への移行性の改善.　日本薬学会第112年会（福岡）, (1992) 3.
  7. Shozo Muranishi : Enhanced GI absorption of peptides by chemical modification. 2nd Jerusalem Conference on Pharmaceutical Sciences and Clinical Pharmacology ( Jerusalem , Israel ), (1992) 5.
  8. 田中浩一郎、村上正裕、山本　昌、村西昌三：In Vitro 反転腸管法を用いたLauroyl-TRH の消化管吸収機構に関する検討. 第8回日本DDS学会総会（札幌）, (1992) 7.
  9. 淀谷悦生、村上正裕、山本　昌、村西昌三：インスリンの消化管吸収に及ぼす蛋白分解酵素阻害剤の影響―小腸および大腸間の部位差―.　第8回日本DDS学会総会（札幌）, (1992) 7.
  10. 高田浩一、藤田卓也、村上正裕、山本　昌、村西昌三：シスプラチンのポリエチレングリコール化修飾による肺近傍リンパ節への移行性の改善.　第8回日本DDS学会総会（札幌）, (1992) 7.
  11. Toshio Taniguchi, Yutaka Tomoda, Yukio Tanaka, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Synthesis of acyloyl lysozyme and improvement of its lymphatic transport following small intestinal administration in rats. 19th International Symposium on Controlled Release of Bioactive Materials ( Orlando , U.S.A. ), (1992) 7.
  12. Hiroyuki Asada, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Improvement of intestinal absorption of insulin by chemical modification with fatty acid. 19th International Symposium on Controlled Release of Bioactive Materials ( Orlando , U.S.A. ), (1992) 7.
  13. Hiroyuki Asada, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Improvement of intestinal absorption of insulin by chemical modification with fatty acid. 6th Japaneses-American Conference of Pharmacokinetics and Biopharmaceutics ( Baffalo , U.S.A. ), (1992) 8.
  14. Toshio Taniguchi, Yutaka Tomoda, Yukio Tanaka, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi : Synthesis of acyl lysozymes and improvement of their lymphatic transport following small intestinal administration in rats. 6th Japaneses-American Conference of Pharmacokinetics and Biopharmaceutics ( Baffalo , U.S.A. ), (1992) 8.
  15. Shozo Muranishi : Drug targeting towards the lymphatics. XⅡth International Symposium on Medicinal Chemistry ( Basel , Switzerland ), (1992) 9.
  16. 佐々木功、藤田卓也、山本　昌、村西昌三、中村英次、今崎　一：消化管における新規TRH 誘導体Azetirelin の安定性と吸収性.　日本薬剤学会第8年会（広島）, (1992) 9.
  17. 淀谷悦生、天満丈裕、藤田卓也、山本　昌、村西昌三：アシル化テトラガストリンの各消化管粘膜透過性における部位差の検討.　日本薬剤学会第8年会（広島）, (1992) 9.
  18. 谷口寿生、西川礼子、藤田卓也、村上正裕、山本　昌、村西昌三：小腸における各種吸収促進剤の有効性と粘膜傷害性に関する検討. 日本薬剤学会第8年会（広島）, (1992) 9.
  19. 浅田博之、村上正裕、山本　昌、村西昌三：肺粘膜ホモジネート中におけるインスリンの安定性に及ぼす各種タンパク分解酵素阻害剤の影響. 日本薬剤学会第8年会（広島）, (1992) 9.
  20. 山本　昌、天満丈裕、道円隆行、田中浩一郎、藤田卓也、村上正裕、村西昌三：In Vitro 摘出腸管を用いた各種脂肪酸修飾ペプチドの粘膜透過性亢進に関する研究.　第23回薬物代謝と薬効・毒性シンポジウム（京都）, (1992) 10.
  21. 田中浩一郎、藤田卓也、村上正裕、山本　昌、村西昌三：Lauroyl-TRH の消化管吸収機構に関する研究. 第7回日本薬物動態学会年会（京都）, (1992) 10.
  22. 高田浩一、藤田卓也、村上正裕、山本　昌、村西昌三：肺内投与後の薬物の肺近傍リンパ系への移行に及ぼす分子量の影響と高分子化シスプラチンのリンパ系への移行性.　第7回日本薬物動態学会年会（京都）, (1992) 10.