田中 智之（教授）
Researchmap: https://researchmap.jp/mast_cell1970/
ORCID: 0000-0002-3468-7694
最近の研究成果について
2024年
Suppression of mast cell activation by GPR35: GPR35 is a primary target of disodium cromoglycate. Oka, M., Akaki, S., Ohno, O., Terasaki, M., Hamaoka-Tamura, Y., Saito M., Kato, S., Inoue, A., Aoki, J., Matsuno, K., Furuta, K., Tanaka, S. J. Pharmacol. Exp. Ther., in press, 2024.
副作用の頻度や程度の低い抗アレルギー薬であるクロムグリク酸ナトリウムは「マスト細胞安定化剤」として知られるが、その標的分子や作用機序は不明であった。In vitroのスクリーニングでマスト細胞安定化剤がオーファンGPR35のアゴニスト活性をもつという報告に基づき、マスト細胞にGPR35が発現すること、またこれを介してIgEを介する抗原刺激による脱顆粒応答が抑制あされることを初めて明らかにした。
2021年
Roles of IgE and histamine in mast cells maturation. Tanaka, S., Furuta, K. Cells, 10, 2170, 2021.
抗IgE抗体の治療効果には血清IgEレベルの低下が関わると考えられているが、IgEの高値がアレルギー疾患の増悪につながるメカニズムは明らかではない。ここではマスト細胞に着目し、IgEがマスト細胞の成熟や応答性の変化にどのような影響を与えるかを議論している（総説）。
2020年
Int. J. Mol. Sci.誌において特集号"Activation and Modulation of Mast Cells"のゲスト編集者を務めました。2報の総説、8報の原著論文、1報のcommunicationを収載しております。ご協力いただきましたマスト細胞研究者に御礼申し上げます。
2019年
Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type Mast Cells by Dexamethasone. Yamada, K., Sato, H., Sakamaki, K., Kamada, M., Okuno, Y., Fukuishi, N., Furuta, K., Tanaka, S. Cells, 8, 12, 2019.
IgE非依存性のマスト細胞の活性化は、蕁麻疹、あるいは近年報告されている種々の慢性炎症性疾患の病態形成を考える上で重要であるが、適当な培養モデルがないために研究の進展は遅れていた。私たちは皮膚型マスト細胞の培養モデルを用いて、ポリカチオンやsubstance Pによるマスト細胞の脱顆粒応答がステロイド性抗炎症薬であるdexamethasoneによって抑制されることを明らかにした。これはマウスの耳介皮膚組織でも再現され、ステロイド性抗炎症薬の新たな作用機序のひとつであることが推察された。
2017年
1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells. Manabe, Y., Yoshimura, M., Sakamaki, K., Inoue, A., Kakinoki, A., Hokari, S., Sakanaka, M., Aoki, J., Miyachi, H., Furuta, K., and Tanaka, S. Eur. J. Immunol., 47, 60-67, 2017.
接触性皮膚炎のモデル抗原として用いられている1-Fluoro-2,4-dinitrobenzene (DNFB)が、ラットマスト細胞に直接作用し、脱顆粒応答を惹起することを明らかにした。このプロセスには、百日咳毒素感受性のGタンパク質共役型受容体が関与することを示唆した。一部の接触性皮膚炎においてマスト細胞が重要な役割を果たすことは報告されているが、抗原が直接マスト細胞を活性化する例は初めて示された。
原著論文
2024Liu, K., Katayama, T., Sato, H., Hamaoka-Tamura, Y., Saito, M., Furuta, K.,Tanaka, S. Staphylococcus aureus delta-toxin induces Ca2+ influx-independent degranulation of murine cultured mast cells. Biol. Pharm. Bull., in press (2024)
Kobayashi, Y., Sakai, K., Tran, N., Ishimaru, K., Sato, T., Nakamura, Y., Nakagomi, D., Tanaka, S., Koizumi, S., Nakao, A. IL-33 sensitizes mast cells to Piezo1 stimulation leading to degranulation. Allergy, in press (2024)
Fujii, K., Miyagawa, R., Tanaka, R., Saito, M., Tanaka, S., Shiratori-Hayashi, M., Tsuda, M., Dong, X., Fujii, M. MrgprA3+ primary sensory neurons mediate acute allergic itch responses in atopic dermatitis model mice. Biol. Pharm. Bull., 47, 1624-1630 (2024)
Taketomi, Y., Higashi, T., Kano, K., Miki, Y., Mochizuki, C., Toyoshima, S., Okayama, Y., Nishito, Y., Nakae, S., Tanaka, S., Tokuoka, S.M., Oda, Y., Shichino, S., Ueha, S., Matsushima, K., Akahoshi, N., Ishii, S., Chun, J., Aoki, J., Murakami, M. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity, 57, 1828-1847 (2024)
Oka, M., Akaki, S., Ohno, O., Terasaki, M., Hamaoka-Tamura, Y., Saito M., Kato, S., Inoue, A., Aoki, J., Matsuno, K., Furuta, K., Tanaka, S.Suppression of mast cell activation by GPR35: GPR35 is a primary target of disodium cromoglycate. J. Pharmacol. Exp. Ther., 389, 76-86 (2024)
2023Plum, T., Binzberger, R., Thiele, R., Shang, F., Postrach, D., Fung, C., Fortea, M., Stakenborg, N., Wang, Z., Tappe-Theodor, A., Poth, T., MacLaren, D. A. A., Boeckxstaens, G., Kuner, R., Pitzer, C., Monyer, H., Xin, C., Bonventre, J. V., Tanaka, S., Voehringer, D., Berghe, P. V., Strid, J., Feyerabend, T. B., and Rodewald, H.-R.Mast cells link immune sensing to antigen-avoidance behaviour. Nature, 620, 634-642 (2023)
Furuta, K., Onishi, H., Ikada, Y., Masaki, K., Tanaka, S., Kaito, C.ATP and its metabolite adenosine cooperatively upregulate the antigen-presenting molecules on dendritic cells leading to IFN-γ production by T cells. J. Biol. Chem., 299, 104587, (2023)
2021Tanaka, S., Furuta, K. Roles of IgE and Hisatmine in Mast Cell Maturation. Cells, 10, 2170 (2021)
2020Masaki, K., Hiraki, Y., Onishi, H., Satoh, Y., Roche, P. A., Tanaka, S., Furuta, K. Ligation of MHC Class II Induces PKC-Dependent Clathrin-mediated Endocytosis of MHC Class II. Cells, 9, 1810 (2020)
Yoshida, K., Ito, M., Sato, N., Obayashi, K., Yamamoto, K., Koizumi, S., Tanaka, S., Furuta, K., Matsuoka, I.Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. J. Immunol., (2020)
Nishimura, K., Okamoto, M., Shibue, R., Mizuta, T., Shibayama, T., Yoshino, T., Murakami, T., Yamaguchi, M., Tanaka, S., Toida, T., Igarashi, K.KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation. PLoS One, 15, e0229744 (2020)
Kakinoki, A., Kameo, T., Yamashita S., Furuta, K., Tanaka, S.Establishment and Characterization of a Murine Mucosal Mast Cell Culture Model. Int. J. Mol. Sci., 21, 236 (2020)
Endo, K., Kito, H., Tanaka, R., Kajikuri, J., Tanaka, S., Elboray, E. E., Suzuki, T., Ohya, S.Possible Contribution of Inflammation-Associated Hypoxia to Increased K2P5.1 K+ Channel Expression in CD4+ T Cells of the Mouse Model for Inflammatory Bowel Disease. Int. J. Mol. Sci., 21, 38 (2020)
2019Yamada, K., Sato, H., Sakamaki, K., Kamada, M., Okuno, Y., Fukuishi, N., Furuta, K., Tanaka, S.Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type Mast Cells by Dexamethasone. Cells, 8, 12 (2019)
Uchida, R., Egawa, T., Fujita, Y., Furuta, K., Taguchi, H., Tanaka, S., Nishida, K. Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation. Mol. Immunol., 105, 32-37 (2019)
2018Kamei, M., Otani, Y., Hayashi, H., Nakamura, T., Yanai, K., Furuta, K., Tanaka, S. Suppression of IFN-γ production in murine splenocytes by histamine receptor antagonists. Int. J. Mol. Sci., 19, 4083 (2018)
Matsuo, Y., Yanase, Y., Irifuku, R., Takahagi, S., Mihara, S., Ishii, K., Kawaguchi, T., Tanaka, A., Iwamoto, K., Watanuki, H., Furuta, K., Tanaka, S., Inoue, A., Aoki, J., Hide, M. Neuromedin-U directly induces degranulation of skin mast cells, presumably via MRGPRX2. Allergy, 73, 2256-2260 (2018)
2017Takeuchi, T., Harada, Y., Moriyama, S., Furuta, K., Tanaka, S., Miyaji, T., Omote, H., Moriyama, Y., and Hiasa, M. Vesicular polyamine transporter mediates vesicular storage and release of polyamine from mast cells. J. Biol. Chem., 292, 3909-3918 (2017)
Manabe, Y., Yoshimura, M., Sakamaki, K., Inoue, A., Kakinoki, A., Hokari, S., Sakanaka, M., Aoki, J., Miyachi, H., Furuta, K., and Tanaka, S. 1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells. Eur. J. Immunol., 47, 60-67 (2017)
2016Hattori, M., Yamazaki, M., Ohashi, W., Tanaka, S., Hattori, K., Todoroki, K., Fujimori, T., Ohtsu, H., Matsuda, N., and Hattori, Y. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.Intensive Care Med. Exp. (ICMx), 4, 36 (2016)
Sakanaka, M., Kurimune, Y., Yamada, K., Hyodo, N., Natsuhara, M., Ichikawa, A., Furuta, K., and Tanaka, S. Down-modulation of antigen-induced activation of murine cultured mast cells sensitized with a highly cytokinergic IgE clone. Immunol. Lett. 174, 1-8 (2016)
Oshikawa, Y., Furuta, K., Tanaka, S., and Ojida, A. Cell surface-anchored fluorescent probe capable of real-time imaging of single mast cell degranulation based on histamine-induced coordination displacement. Anal. Chem. 88, 1526-1529 (2016)
2014Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y. Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. J. Immunol. 192, 1130-1137 (2014)
Takeuchi, M., Sato, Y., Ohno, K., Tanaka, S., Takata, K., Gion, Y., Orita,Y., Ito, T., Tachibana, T. and Yoshino, T. T helper 2 and regulatory T cell cytokine production by mast cells: A key factor in the pathogenesis of IgG4-related disease. Mod. Pathol. 27, 1126-1136 (2014)
Taura, A., Furuta, K., Yamaguchi, T., Kawabata, K., and Tanaka, S. Regulation of histamine synthesis and tryptase expression through transcription factors, growth factor independent 1 (Gfi1) and Gfi1b, in murine cultured mast cells. Biol. Pharm. Bull. 37, 81-86 (2014)
Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R. L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S. Histamine synthesis is required for granule maturation of murine mast cells. Eur. J. Immunol. 44, 204-214 (2014)
2013Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., Murakami, M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis. Nat. Immunol. 14, 554-563 (2013)
Kadota, Y., Sakai, N., Fujikawa, R., Aoyama, E., Zhong, M., Tanaka, S., and Gohda, E. Dextran sulfate-induced degradation of spontaneously apoptic B cells. Int. Immunopharmacol. 15, 581-587 (2013)
2012Yamaguchi, T., Tashiro, K., Tanaka, S., Katayama, S., Ishida, W., Fukuda, K., Fukushima, A., Araki, R., Abe, M., Mizuguchi, H., and Kawabata, K. Two-step differentiation of mast cells from induced pluripotent stem cells. Stem Cells Dev., 22, 726-734 (2012)
Sugiura, Y., Hiramatsu, K., Hamauzu, R., Motoki, T., Miyazaki, M., Uto, H., Tsubouchi, H., Tanaka, S., and Gohda, E. Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymixin B. Cytokine 60, 205-211(2012)
Takano, H., Furuta, K., Yamashita, K., Sakanaka, M., Itano, N., Gohda, E., Nakayama, K., Kimata, K., Sugimoto, Y., Ichikawa, A., and Tanaka, S. Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. Biol. Pharm. Bull. 35, 408-412 (2012) Highlighted paper selected by Editor-in-Chief
2011Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishi, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., and Nakano, H. Crucial role for autophagy in degranulation of mast cells. J. Allergy Clin. Immunol. 127, 1267-1276 (2011)
2010Goto, T., Sarker, M. M. R., Zhong, M., Tanaka, S., and Gohda, E. Enhancement of IgM production in B cells by the extract of red bell pepper. J. Health Sci. 56, 304-309 (2010)
Sakanaka, M., Furuta, K., Ichikawa, A., and Tanaka, S. Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSP.Z Immunol. Lett. 128, 74-79 (2010)
Matsuura, J., Sakanaka, M., Sato, N., Ichikawa, A., and Tanaka, S. Suppression of CXCR4 expression in mast cells upon IgE-mediated antigen stimulation. Inflamm. Res. 59, 123-127, (2010)
2009Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., and Sugimoto, Y. Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. Biochem. Biophys. Res. Commun. 389, 678-682 (2009)
Sato, N., Tanaka, S.*, Matsuura, J., Takasu, Y., and Ichikawa, A. Interleukin-4-mediated suppression of histamine synthesis in a murine mast cell line, BNu-2cl3. Biol. Pharm. Bull. 32, 1800-1802 (2009)
Tsuchiya, S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., and Sugimoto, Y. Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method. BMC Genomics 10, 35 (2009)
Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Kimata, K., Nakayama, K., Sugimoto, Y., and Tanaka, S. Involvement of CD44 in mast cell proliferation during terminal differentiation. Lab. Invest. 89, 446-455 (2009)
2008Sakanaka, M., Tanaka, S.*, Sugimoto, Y., and Ichikawa, A. Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. Am. J. Physiol. Cell Physiol. 295, C1427-C1433 (2008)
Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takematsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, S. Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells. FEBS Lett. 582, 1444-1450 (2008)
Kataoka, H., Sakanaka, M., Semma, M., Yamamoto, T., Hirota, S., Tanaka, S.*, and Ichikawa, A. PGE2-receptor subtype EP4-dependent adherence of mastocytoma P-815 cells to matrix components in subcutaneous tissues overlaying inside surface of air pouch cavity in CDF1 mouse. Inflamm. Res. 57, 362-366 (2008)
2007Ueta, M., Nakamura, T., Tanaka, S., Kojima, K., and Kinoshita, S. Development of eosinophilic conjunctival inflammation at late-phase reaction in mast cell-deficient mice. J. Allergy Clin. Immunol. 120, 476-478 (2007)
Taketomi, Y., Sunaga, K., Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T., Chang, H., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I. Impaired mast cell maturation and degranulation and attenuated allergic responses in NDRG1-deficient mice. J. Immunol. 178, 7042-7053 (2007)
Furuta, K., Nakayama, K., Sugimoto, Y., Ichikawa, A., and Tanaka, S. Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. J. Biol. Chem. 282, 13438-13446 (2007)
2006Furuta, K., Ichikawa, A., Nakayama, K., and Tanaka, S. Membrane orientation of the precursor 74-kDa form of L-histidine decarboxylase. Inflamm. Res. 55, 185-191 (2006)
2005Liu, Y., Furuta, K., Teshima, R., Shirata, N., Sugimoto, Y., Ichikawa, A., and Tanaka, S. Critical role of PKCβII in activation of mast cells by monomeric IgE. J. Biol. Chem. 280, 38976-38981 (2005)
Sugimoto, Y., Fukada, Y., Mori, D., Tanaka, S., Yamane, H., Okuno, Y., Deai, K., Tsuchiya, S., Tsujimoto, G., and Ichikawa, A. Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils. J. Immunol. 175, 2606-2612. (2005)
Kunikata, T., Yamane, H., Segi, E., Matsuoka, T., Sugimoto, Y., Tanaka, S., Tanaka, H., Nagai, H., Ichikawa, A., and Narumiya, S. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat. Immunol. 6, 524-531. (2005)
Tanaka, S., Mikura, S., Hashimoto, E., Sugimoto, Y., and Ichikawa, A. Ca2+ influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE. Eur. J. Immunol. 35, 460-468 (2005)
2004Nakamura, E., Kataoka, T., Furutani, K., Jimbo, K., Aihara, T., Tanaka, S., Ichikawa, A., Ohtsu, H., and Okabe, S. Lack of histamine alters gastric mucosal morphology: Comparison between histidine decarboxylase-deficient and mast cell-deficient mice. Am. J. Physiol.-Gastrointest. Liver. Physiol. 287, G1053-1061 (2004)
Kawazoe, Y., Tanaka, S., and Uesugi, M. Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem. Biol. 11, 907-913 (2004)
Tanaka, S., Deai, K., Konomi, A., Takahashi, K., Yamane, H., Sugimoto, Y., and Ichikawa, A. Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes. Eur. J. Immunol. 34, 1472-1482 (2004)
Sugimoto, Y., Nakato, T., Kita, A., Takahashi, Y., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. J. Biol. Chem. 279, 11016-11026. (2004).
2003Sugimoto, Y., Nakato, T., Kita, A., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors. Life Sci. 74, 135-141. (2003)
Tsuchiya, S., Tanaka, S., Sugimoto, Y., Katsuyama, M., Ikegami, R., and Ichikawa, A. Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor subtype EP2 gene. Genes Cells 8, 747-758. (2003)
Wagner, W., Ichikawa, A., Tanaka, S., Panula, P., and Fogel, W. A. Mouse mammary epithelial histamine system. J. Physiol. Pharmacol. 54, 211-223 (2003).
Furutani, K., Aihara, T., Nakamura, E., Tanaka, S., Ichikawa, A., Ohtsu, H., and Okabe, S. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. J. Pharmacol. Exp. Ther. 307, 331-338 (2003).
Tanaka, S., Deai, K., Inagaki, M., and Ichikawa, A. Uptake of histamine by mouse peritoneal macrophages and a macrophage cell line, RAW264.7. Am. J. Physiol.-Cell Physiol. 285, C592-C598 (2003).
Hunyady, B., Zolyomi, A., Czimmer, J., Mozsik, G., Kozixz, T., Buzas, E., Tanaka, S., Ichikawa, A., Nagy, A., Palkovits, M., and Falus, A. Expanded parietal cell pool in transgenic mice unable to synthesize histamine. Scand. J. Gastroenterol. 38 (2), 133-140 (2003).
Wagner, W., Tanaka, S., Ichikawa, A., and Fogel, W. A. Phosphorothioate antisense oligodeoxynucleotides against histidine decarboxylase: a study in mouse mammary epithelial cell cultures. Inflamm. Res. 52 (suppl 1), S59-S62 (2003).
Hatae, N., Kita, A., Tanaka, S., Sugimoto, Y., and Ichikawa, A. Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two PGE2 receptor subtypes, EP3 and EP4. J. Biol. Chem. 278, 17977-17981 (2003)
Segi, E., Haraguchi, K., Sugimoto, Y., Tsuji, M., Tsunekawa, H., Tamba, S., Tsuboi, K., Tanaka, S., and Ichikawa, A. Expression of messenger RNA for prostaglandin E receptor subtypes EP4/EP2 and cyclooxygenase isozymes in mouse periovulatory follicles and oviducts during superovulation. Biol. Reprod. 68, 804-811. (2003)
2002Tabata, H., Tanaka, S., Sugimoto, Y., Kanki, H., Kaneko, S., and Ichikawa, A. Possible coupling of prostaglandin E receptor EP1 to TRP5 expressed in X. laevis oocytes. Biochem. Biophys. Res. Commun. 298, 398-402. (2002)
Takahashi, K., Tanaka, S., Furuta, K., and Ichikawa, A. Histamine H2 receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model. Biochem. Biophys. Res. Commun. 297, 1205-1210 (2002).
Tanaka, S., Takasu, Y., Mikura, S., Satoh, N., and Ichikawa, A. Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow derived mast cells. J. Exp. Med. 196, 229-235 (2002).
Ohtsu, H., Kuramasu, A., Tanaka, S., Terui, T., Hirasawa, N., Hara, M., Makabe-Kobayashi, Y., Yamada, N., Yanai, K., Sakurai, E., Okada, M., Ohuchi, K., Ichikawa, A., Nagy, A., and Watanabe, T. Plasma extravasation induced by dietary supplemented histamine in histamine-free mice. Eur. J. Immunol. 32, 1698-1708 (2002)
Safina, F., Tanaka, S., Inagaki, M., Tsuboi, K., Sugimoto, Y., and Ichikawa, A. Expression of L-histidine decarboxylase in mouse male germ cells. J. Biol. Chem. 277, 14211-14215 (2002)
Tanaka, S., Hamada, K., Yamada, N., Sugita, Y., Tonai, S., Hunyady, B., Palkovits, M., Falus, A., Watanabe, T., Okabe, S., Ohtsu, H., Ichikawa, A., and Nagy, A. Gastric acid secretion in L-histidine decarboxylase deficient mice. Gastroenterology 122, 145-155 (2002)
Tanaka, S., Konomi, A., Takahashi, K., and Ichikawa, A. Histamine synthesis in mouse polymorphonuclear neutrophils. Inflamm. Res. 51 (suppl1), S17-S18 (2002)
2001Ohtsu, H., Tanaka, S., Terui, T., Hori, Y., Makabe-Kobayashi, Y., Pejler, G., Tchougounova, E., Hellman, L., Gertsenstein, M., Hirasawa, N., Sakurai, E., Buzas, E., Kovacs, P., Csaba, G., Kittel, A., Okada, M., Hara, M., Mar, L., Numayama-Tsuruta, K., Ishigaki-Suzuki, S., Ohuchi, K., Ichikawa, A., Falus, A., Watanabe, T., and Nagy, A. Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 502, 53-56 (2001)
Tanaka, S., and Ichikawa, A. Intracellular localization of histidine decarboxylase. Inflamm. Res. 50 (suppl2), S98-S99 (2001)
Takahashi, K,. Tanaka, S., and Ichikawa, A. Effect of cimetidine on intratumoral cytokine expression in an experimental tumor. Biochem. Biophys. Res. Commun. 281(5), 1113-1119 (2001)
2000Yamane, H., Sugimoto, Y., Tanaka, S., and Ichikawa, A. Prostaglandin E2 receptor, EP2 and EP4, differentially modulate TNF-α and IL-6 production induced by lipopolysuccharide in mouse peritoneal neutrophils. Biochem. Biophys. Res. Commun. 278, 224-228. (2000)
1998Suzuki, S., Tanaka, S., Nemoto, K., and Ichikawa, A. Membrane targeting and binding of the 74 kDa form of mouse L-histidine decarboxylase via its carboxyl-terminal sequence. FEBS Lett. 437, 44-48. (1998)
Tanaka, S., Nemoto, K., Yamamura, E., and Ichikawa, A. Intracellular localization of the 74- and 53- kDa forms of L-histidine decarboxylase in a rat basophilic/mast cell line, RBL-2H3.J. Biol. Chem. 273, 8177-8182. (1998)
Ichikawa, A., Funakoshi, E., Tanaka, S., Nemoto, K., and Fukui, T. Benzamidine-sensitive proteinase in activated cleavage of recombinant 74 kDa histidine decarboxylase into its 53 kDa form in mastocytoma cells. Inflamm. Res. 47, suppl 1, S46-S47. (1998)
1997Tanaka, S., Nemoto, K., Yamamura, E., Ohmura, S., and Ichikawa, A. Degradation of the 74 kDa form of L-histidine decarboxylase via the ubiquitin-proteasome pathway in a rat basophilic/mast cell line (RBL-2H3). FEBS Lett. 417, 203-207. (1997)
Nakagawa, S., Okaya, Y., Yatsunami, K., Tanaka, S., Ohtsu, H., Fukui, T., Watanabe, T., and Ichikawa, A. Identification of multiple regulatory elements of human L-histidine decarboxylase gene. J. Biochem. 121, 935-940. (1997)
1996Ohtsu, H., Kuramasu, A., Suzuki, S., Igarashi, K., Ohuchi, Y., Sato, M., Tanaka, S., Nakagawa, S., Shirato, K., Yamamoto, M., Ichikawa, A., and Watanabe, T. Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation. J. Biol. Chem. 271, 28439-28444. (1996)
Asahara, M., Mushiake, S., Shimada, S., Fukui, H., Kinoshita, Y., Kawanami, C., Watanabe, T., Tanaka, S., Ichikawa, A., Uchiyama, Y., Narushima, Y. Takasawa, S., Okamato, H., Tohyama, M., and Chiba, T. Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Gastroenterology. 111, 45-55. (1996)
1995Tanaka, S., Funakoshi, E., Kawahara, A., Nemoto, K., Fukui, T., Suzuki, T., Igarashi, K., and Ichikawa, A. Effect of repeated cold stress on mouse stomach histidine decarboxylase.Meth. Find. Exp. Clin. Pharmacol. 17(C), 25-29. (1995)
Ichikawa, A., Fukui, T., Yamamoto, J., Ohgoh, M., Tanaka, S., and Funakoshi, E. De novo synthesis and posttranslational processing of L-histidine decarboxylase in mice. Meth. Find. Exp. Clin. Pharmacol. 17(C), 5-9. (1995)
Tanaka, S., Fukui, T., Yamamoto, J., Shima, Y., Kume, T., Ohgo, M and Ichikawa, A. Processing and activation of recombinant mouse mastocytoma histidine decarboxylase in the particulate fraction of Sf9 cells by porcine pancreatic elastase. Biochim. Biophys. Acta. 1253, 9-12. (1995)
1993Yamamoto, J., Fukui, T., Suzuki, K., Tanaka, S., Yatsunami, K., and Ichikawa, A. Expression and characterization of recombinant mouse mastocytoma histidine decarboxylase. Biochim. Biophys. Acta. 1216, 431-440. (1993)
総説
Tanaka, S., Van Overveld, F. J. Editorial: Novel insights into inflammatory roles of mast cells and basophils. Front. Immunol. (2023)
Tanaka, S. Phenotypic and functional diversity of mast cells. (Editorial) Int. J. Mol. Sci. 21, E3835 (2020)
Ichikawa, A., Sugimoto, Y., and Tanaka, S. Molecular Biology of Histidine Decarboxylase and Prostaglandin Receptors. Proc. Jpn. Acad., Ser. B 86, 848-866 (2010)
Tanaka, S. Targeting CD44 in mast cell regulation. Expert Opin. Ther. Targets 14 (1), 31-43 (2010)
Tanaka, S., and Ichikawa, A. Immune regulatory roles of histamine produced by leukocytes. J. Pharmacol. Sci. 101, 19-23 (2006)
日本語記事
田中 智之：マスト細胞・好塩基球研究の新展開：日薬理誌 159 (1), 44-47, 2024
田中 智之：望ましい研究のあり方：薬学教育 7, 105-112, 2023
田中 智之、加納圭、小出隆規：研究公正：現状とELSI/RRIにおける重要性：研究 技術 計画 37 (3), 325-338, 2022
田中 智之：「研究スキル売買」から見えるもの：化学 77, 11, 2022
田中 智之：「研究不正」を見つけたら……：現代化学 604, 30-33, 2021
田中 智之：学術出版における研究公正の動向：薬学図書館 65 (4), 177-181, 2020
田中 智之：Histamineと掻痒：臨床免疫・アレルギー科 69 (4), 342-347, 2018
田中 智之：研究公正を目指す取り組み：現状と新しい動き：薬学雑誌 138 (4), 477-486, 2018
田中 智之：誠実な研究活動のために(Part 2)：ファルマシア 52(4), 317-321, 2016
田中 智之：誠実な研究活動のために(Part 1)：ファルマシア 52(2), 131-135, 2016
田中 智之：創薬の標的としてのマスト細胞：MEDCHEM NEWS 24巻、33-38 (2014)
田中 智之、古田 和幸：ヒスタミンとアナフィラキシー：アレルギー・免疫 20巻、50-54 (2013)
田中 智之、西田 圭吾：マスト細胞研究の新たな展開：薬学雑誌 131巻、59-61 (2011)
田中 智之：皮膚型マスト細胞モデルの確立とその解析：薬学雑誌 131巻、63-71 (2011)
田中 智之：マスト細胞の分化に伴う機能制御（日本生化学会奨励賞総説）：生化学 第82巻、1021-1032 (2010)
田中 智之：マスト細胞の成熟とヒアルロン酸：表面 45巻、312-321 (2007)
田中 智之：IgEを介するマスト細胞活性化の多様性、特集「マスト細胞の活性化をめぐって」：臨床免疫・アレルギー科 47巻、421-426 (2007)
田中 智之：マスト細胞におけるIgEを介したヒスタミン合成の誘導機構、特集「アレルギー性炎症反応におけるヒスタミンの役割と抗ヒスタミン薬」：アレルギー科 21巻、438-444 (2006)
田中 智之：単量体IgEによるマスト細胞の活性化、特集「アレルギー疾患におけるマスト細胞の位置づけ」（編集・羅 智靖）：アレルギー・免疫 13 (6), 50-56 (2006)
田中 智之：ヒスタミン生合成を介して発現する生理機能の解析（日本薬学会奨励賞受賞記念総説）：薬学雑誌 123 (7), 547-559 (2003).
田中 智之：新たな抗アレルギー薬の標的？ヒスタミン H4 受容体の発見：ファルマシア 38 (1), 64-65 (2002)
田中 智之、市川 厚：ヒスタミン生合成の分子機構「ヒスタミン研究の最近の進歩」別冊・医学のあゆみ（医歯薬出版）(2000)
田中 智之：SRP 非依存的な小胞体へのタンパク質輸送：生化学 72 (2), 121-125 (2000)
市川 厚、田中 智之：ヒスチジン脱炭酸酵素の分子生物学：医学のあゆみ 188 (3), 163-167 (1999)
著書・訳書
「図解 薬学・副作用学（改訂3版）」 川西正祐、小野秀樹、賀川義之（編）南山堂（2023年）：「薬物アレルギー」
「薬学演習 Ⅱ．基礎科学」日本薬学会（編）東京化学同人（2021年）：編集委員
Activation and modulation of mast cells. Tanaka, S. MDPI, ISBN 978-3-03936-564-7
「呼吸器／免疫・炎症・アレルギー／骨・関節（臨床薬学テキストシリーズ）」乾賢一、赤池昭紀、稲垣直樹、川合眞一（編）中山書店（2020年）：抗アレルギー薬、免疫抑制薬（田中智之、川合眞一）
「科学者の研究倫理 化学・ライフサイエンスを中心に」田中智之、小出隆規、安井裕之 東京化学同人（2018年）
「薬学研究（スタンダード薬学シリーズⅡ）」日本薬学会（編）東京化学同人（2017年）：第Ⅰ部「研究の心構え」
「図解 薬学・副作用学（改訂2版）」 川西正祐、小野秀樹、賀川義之（編）南山堂（2017年）：「薬物アレルギー」
「キャンベルファーレル生化学」 川嵜敏祐、金田典雄（監訳）廣川書店（2011年）：14章「ウイルス、がん、免疫学」翻訳
「わかりやすい免疫学」 市川厚・田中智之（編著）廣川書店（2008年）
Regulation of mammalian histamine synthesis: histidine decarboxylase. Tanaka, S. and Ichikawa, A. in “Biomedical Aspects of Histamine: Current Perspectives” (ed. Khardori, N., Shahid, M., Khan, RA, and Tripathi, T, Springer)
その他
Tiligada, E., Gibbs, B. F., and Tanaka, S. "Novel insights into the roles of mast cells and basophils": Joint Webinar of the Japanese and the European Histamine Research Society (JHRS/EHRS) Inflamm. Res.(2022)
田中 智之「ダメな統計学 悲惨なほど完全なる手引書」（書評）ファルマシア 53, 12, 1207 (2017)
Tanaka, S. and Ichikawa, A. Histamine biosynthesis and function. eLS (Encyclopedia of Life Science, WILEY) (2012)
田中 智之：組織環境におけるマスト細胞の新たな機能（最近の話題）：日薬理誌 138, 301 (2011)
田中 智之：網羅的ゲノムスクリーニングによる新たな薬物の標的探索法の開発（注目の論文）：化学 59 (11), 60-61 (2004)