Publications

研究業績

研究業績 Publications


 

 

2021

 [原著論文・総説・著書] 

1)  Marina Ikeda, Tadashi Watanabe, Akihiro Ito, Masahiro Fujimuro:
Herpes simplex virus 1 infection induces ubiquitination of UBE1a.
Biochem J.,  478, 261-279. 2021
 
 2) Atsuko Sugimoto, Yuichi Abe, Tadashi Watanabe, Kohei Hosokawa, Jun Adachi, Takeshi Tomonaga, Yasumasa Iwatani, Takayuki Murata, Masahiro Fujimuro:
The FAT10 post-translational modification is involved in the lytic replication of Kaposi's sarcoma-associated herpesvirus.
J. Virol., in press
 
3)Sayaka Tsurumi, Tadashi Watanabe, Yuki Iwaisako, Youichi Suzuki, Takashi Nakano, Masahiro Fujimuro:
Kaposi's sarcoma-associated herpesvirus ORF17 plays a key role in capsid maturation.
Virology, 558, 76-85. 2021
 
4) Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro:
Kaposi's Sarcoma-Associated Herpesvirus ORF7 Is Essential for Virus Production.
Microorganisms, 9, 1169. 2021
 

2020

 [原著論文・総説・著書]

1) Tadashi Watanabe, Mayu Nishimura, Taisuke Izumi, Kazushi Kuriyama, Yuki Iwaisako, Kohei Hosokawa, Akifumi Takaori-Kondo, Masahiro Fujimuro:
Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction with ORF34.
J.Virology , 94, e01300-19. 2020

2) Kohei Hosokawa, Hanako Ishimaru, Tadashi Watanabe, Masahiro Fujimuro:
The lysosome pathway degrades CD81 on the cell surface by poly-ubiquitination and clathrin-mediated endocytosi.s
Biol. Pharm. Bull., 43, 540-545. 2020

3) Hanako Ishimaru, Kohei Hosokawa, Atsuko Sugimoto, Riho Tanaka, Tadashi Watanabe, Masahiro Fujimuro:
MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway.
Sci. Rep., 10, 6671. 2020

4) Marina Ikeda, Akihiro Ito, Yuichi Sekine, Masahiro Fujimuro:
UBE1a Suppresses Herpes Simplex Virus-1 Replication.
Viruses, 12, 1391. 2020

2019

 [原著論文・総説・著書] 

1) Misato Moriguchi, Tadashi Watanabe, Ayano Kadota, Masahiro Fujimuro:
Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression.
Front Oncol. 2019 19; 9: 83.
 
2) Yuki Okano, Noriko Saito-Tarashima, Madoka Kurosawa, Ai Iwabu, Masashi Ota, Tadashi Watanabe, Fumihiro Kato, Takayuki Hishiki, Masahiro Fujimuro, Noriaki Minakawa:
Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents.
Bioorg. Med. Chem. 2019 27: 2181-2186.
 
3) Tetsuya Suzuki, Yusuke Wakao, Tadashi Watanabe, Mika Hori, Yoshito Ikeda, Hiroyuki Tsuchiya, Kentaro Kogure, Mariko Harada-Shiba, Masahiro Fujimuro, Hiroyuki Kamiya:
No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo.
Nucleosides Nucleotides Nucleic Acids. 2019 38: 942-949.
 
4) Misato Moriguchi, Tadashi Watanabe, Masahiro Fujimuro:
Capsaicin Induces ATF4 Translation with Upregulation of CHOP, GADD34 and PUMA.
Biol. Pharm. Bull. 2019 42, 1428-1432.
 
5) Yuki Ishiura, Hanako Ishimaru, Tadashi Watanabe, Masahiro Fujimuro:
Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation.
Biol Pharm Bull. 2019 42, 2109-2112.
 
6) 藤室雅弘
遺伝子治療とゲノム編集技術の進展,
「iPS細胞や再生医療分野の理解を深めるための人材育成事業基礎講座」
(公財)京都産業21 イノベーション推進部 新産業創出グループ, p46-67, (2019)
 
7) 野口耕司, 藤室雅弘
次世代創薬に向けた感染症とがんの横断的基礎研究の進展
~ヒトがん関連病原体に対する最先端研究を先導する薬学研究者~
「YAKUGAKU ZASSHI」
公益社団法人日本薬学会 ,139 p.61-62 (2019).
 
8) 渡部匡史, 藤室雅弘
カポジ肉腫関連ヘルペスウイルスの複製機構と創薬研究
YAKUGAKU ZASSHI
公益社団法人日本薬学会,139 p.69-73 (2019).
 
 

 

2018

 [原著論文・総説・著書]

1) Mel Campbell, Tadashi Watanabe, Kazushi Nakano , Ryan R. Davis, Yuanzhi Lyu, Cliford G. Tepper, Bryth Durbin-Johnson, Masahiro Fujimuro, Yoshihiro Izumiya:
KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation.
Nature Communications, 9, 49 (2018). doi: 10.1038/s41467-017-02089-9.
 
2) Keiko Ogawa, Seikou Nakamura, Kouhei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda:

New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1.

Journal of Natural Medicine, 72, 439-447 (2018). doi: 10.1007/s11418-017-1166-6. 
 
3) Yusuke Baba, Zenpei Shigemi, Naoko Hara, Misato Moriguchi, Marina Ikeda, Tadashi Watanabe, Masahiro Fujimuro:

Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation.

International Journal of Oncology, 52, 505-517 (2018). doi: 10.3892/ijo.2017.4215. 
 
4) Tadashi Watanabe, Atsuko Sugimoto, Kouhei Hosokawa, Masahiro Fujimuro:
Signal Transduction Pathways Associated with KSHV-Related Tumors
Ch15, pp.321-355, Human Herpesviruses (Eds. Yasushi Kawaguchi, Yasuko Mori, Hiroshi Kimura), Springer Singapore (2018).
 

 

2017

 [原著論文・総説・著書]

1)Shigemi Zenpei, Manabe Kazuki, Hara Naoko, Baba Yusuke, Hosokawa Kohei, Kagawa Hiroki, Watanabe Tadashi, Fujimuro Masahiro: 
Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells.
Chemico-Biological Interactions, 266, 28–37 (2017).
 
2)Nishimura Mayu, Watanabe Tadashi, Yagi Syota, Yamanaka Takahiro, Fujimuro Masahiro:
Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production.
Scientific Reports, 7, 329 (2017).
 

 

2016

 [原著論文・総説・著書]

1Zenpei Shigemi, Yusuke Baba, Naoko Hara, Jumpei Matsuhiro, Hiroki Kagawa, Tadashi Watanabe, Masahiro Fujimuro:
Effects of ER stress on unfolded protein responses, cell survival, and viral replication in primary effusion lymphoma,
Biochemical and Biophysical Research Communications469, 565-572 (2016).
 
2Shiori Nakata, Tadashi Watanabe, Koji Nakagawa, Hiroshi Takeda, Akihiro Ito, Masahiro Fujimuro:
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage,
Biochemical and Biophysical Research Communications, 472, 46-52 (2016).
 
3Zenpei Shigemi, Yoshiki Furukawa, Kohei Hosokawa, Setsuya Minami, Jumpei Matsuhiro, Shiori Nakata,  Tadashi Watanabe, Hiroki Kagawa, Koji Nakagawa, Hiroshi Takeda, Masahiro Fujimuro:
Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma,
International Journal of Oncology, 48, 293-304 (2016).
 
4Iyoko Katoh, Nahoko Fukunishi, Masahiro Fujimuro, Hirotake Kasai, Kohji Moriishi, Ryu-Ichiro Hata, Shun-ichi Kurata:
Repression of Wnt/β-catenin response elements by p63 (TP63),
Cell Cycle, 15, (NO. 5), 699-710 (2016).
 
5Takeshi Akiyama, Tiengkham Pongvongsa, Souraxay Phrommala, Tomoyo Taniguchi, Yuba Inamine, Rie Takeuchi, Tadashi Watanabe, Futoshi Nishimoto, Kazuhiko Moji, Shigeyuki Kano, Hisami Watanabe, Jun Kobayashi:
Asymptomatic malaria, growth status, and anaemia among children in Lao People’s Democratic Republic: a cross‑sectional study.
Malaria Journal15, 499 (2016).
 

 

2015

 [原著論文・総説・著書]

1)  渡部匡史、藤室雅弘: 3EBNA, 
EBウイルス, 高田賢蔵監修, pp17-24, 診断と治療社 (2015).
 

 

2014

 [原著論文・総説・著書]

1)  Nobunao Wakabayashi, John J. Skoko, Dionysios V. Chartoumpekis, Shoko Kimura, Stephen L. Slocum, Kentaro Noda, Dushani L. Palliyaguru, Masahiro Fujimuro, Patricia A. Boley, Yugo Tanaka, Norihisa Shigemura, Shyam Biswal, Masayuki Yamamoto and Thomas W. Kensler :
Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by Notch signaling.  
Mol. Cell. Biol. 34, 653-663 (2014).
 
2)  Kazufumi Wakao, Tadashi Watanabe, Tadatoshi Takadama, Sadaharu Ui, Zenpei Shigemi, Hiroki Kagawa, Chizuka Higashi, Rie Ohga, Takahiro Taira, Masahiro Fujimuro :
Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells.  
Biochem. Biophys. Res. Commun. 444, 135-140 (2014).
 
3)  Tadashi Watanabe, Shigeo Nakamura, Toshiya Ono, Sadaharu Ui, Syota Yagi, Hiroki Kagawa, Hisami Watanabe, Tomoyuki Ohe, Tadahiko Mashino, Masahiro Fujimuro :
Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.
Biochem. Biophys. Res. Commun. 451, 93-100 (2014).
 

 

2013

 [原著論文・総説・著書]

1) 藤室 雅弘:
3 3-7タンパク質の品質管理と分解 
新細胞生物学, 竹鼻 眞、高橋 悟、野尻 久雄 編, pp.90-95, 廣川書店 (2013).
 
2) 藤室 雅弘:
66-16-4細胞分裂と増殖 
新細胞生物学, 竹鼻 眞、高橋 悟、野尻 久雄 編, pp.151-184, 廣川書店 (2013).
 

 

2012

 [原著論文・総説・著書]

 1. 藤室 雅弘.
第13章 ウイルス発がん がん増殖と悪性化の分子機構,
宮澤 恵二、伊東 進 編, pp.161-174, 化学同人(2012).
 
2. Higashi C, Saji C, Yamada K, Kagawa H, Ohga R, Taira T and Fujimuro M.
The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
Biol. Pharm. Bull., 35, 725-730 (2012).
 
3. Nakazawa T, Ohmae T, Fujimuro M, Ito M, Nishinaga T and Iyoda M.
Syntheses, molecular structures, and antiviral activities of 1- and 2-(20-deoxy-D-ribofuranosyl)cyclohepta[d][1,2,3]triazol-6(1H)-ones and1-(20-deoxy- D-ribofuranosyl)cyclohepta[b]pyrrol-8(1H)-one.
Tetrahedron, 68, 5368-5374 (2012)
 
4. Yamanokuchi R, Imada K, Miyazaki M, Kato H, Watanabe T, Fujimuro M, Saeki Y, Yoshinaga S, Terasawa H, Iwasaki N, Rotinsulu H, Losung F, Remy E.P. Mangindaan, Namikoshi M, Nicole J. de Voogd, Yokosawa H and Tsukamoto S.
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme from the marine sponge Hyrtios reticulates.  
Bioorg. Med. Chem., 20, 4437-4442 (2012)
 
5. Watanabe T, Urano E, Miyauchi K, Ichikawa R, Hamatake M, Misawa N, Sato K, Ebina H, Koyanagi Y and Komano J
The hematopoietic cell-specific Rho GTPase inhibitor ARHGDIB/D4GDI limits HIV type 1 replication.
AIDS Res. Hum. Retroviruses, 28, 913-922 (2012).
 
6. Ashizawa A, Higashi C, Masuda K, Ohga R, Taira T and Fujimuro M.
The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus.
Frontiers in Vrology, 3, 66 (2012).
 

 

2011

 [原著論文・総説・著書]

1. Saji C, Higashi C, Niinaka Y, Yamada K, Noguchi K, Fujimuro M.
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.   
Biochem. Biophys. Res. Commun., 415, 573-578, 2011

2. Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S.
Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins.
J Biol. Chem., 286, 9009-9019, 2011

3. Kagawa H, Shino Y, Kobayashi D, Demizu S, Shimada M, Ariga H, Kawahara H.
A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1.
PLoS One. 2011 Apr 13;6(4):e18638.
 

 

2010

 [原著論文・総説・著書]

1. Niinaka Y, Harada K, Fujimuro M, Oda M, Haga A, Hosoki M, Uzawa N, Arai N, Yamaguchi S, Yamashiro M, and Raz A.
Silencing of autocrine motility factor induces mesenchymal to epithelial transition and suppression of osteosarcoma pulmonary metastasis.
Cancer Res., 70, 9483-9493, 2010

2. Yoshioka H, Noguchi K, Katayama K, Mitsuhashi J, Yamagoe S, Fujimuro M, Sugimoto Y.
Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a. 
Biochem. Biophys. Res. Commun., 394, 1000-1005 2010

3. Ikeda O, Miyasaka Y, Yoshida R, Mizushima A, Oritani K, Sekine Y, Kuroda M, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T.
BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
FEBS Lett. 584, 865-872, 2010

4. Minami R, Hayakawa A, Kagawa H, Yanagi Y, Yokosawa H, Kawahara H.
BAG-6 is essential for selective elimination of defective proteasomal substrates.
J Cell Biol. 2010 Aug 23;190(4):637-50.

5. 藤室 雅弘, 横沢 英良 (2010).
プロテアソームとタンパク質分解.
生物薬科学実験講座「細胞の構造とオルガネラ」, pp. 117-131, 廣川書店, 東京.

6. 小柳義夫, 渡部匡史.
HIV増殖機構と抗HIV薬の作用機序.
日本臨牀 第68巻第3号: 378-381, 2010

 

 

2009

 [原著論文・総説・著書]

 1. 藤室 雅弘. ウイルスによる分子海賊:カポジ肉腫関連ヘルペスウイルスによるユビキチンシステムとシグナル伝達の脱制御. 
山梨医科学雑誌, Vol.24, 39-53 2009

2. Ikeda O, Sekine Y, Mizushima A, Oritani K, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T
BS69 negatively regulates the canonical NF-kB activation induced by Epstein-Barr virus-derived LMP1.
FEBS Lett. 583, 1567-1574, 2009

3. Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M.
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Intern Med 48, 1311-1313, 2009

4. Ikeda O, Togi S, Kamitani S, Muromoto R, Sekine Y, Nanbo A, Fujimuro M, Matsuda T.
Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.
Biol. Pharm. Bull. 32, 1283-1285, 2009

5. Muromoto R, Ikeda O, Okabe K, Togi S, Kamitani S, Fujimuro M, Harada S, Oritani K, Matsuda T. Epstein–Barr virus-derived EBNA2 regulates STAT3 activation.
Biochem. Biophys. Res. Commun., 378, 439-443, 2009
 

 

1992-2008

 [原著論文・総説・著書]

1. Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, Sawa A.
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Mol Psychiatry. 13, 1138-1148, 2008
 
2. Fujimuro M. Hayward SD. Yokosawa H.
Molecular Piracy: Manipulation of the Ubiquitin System by Kaposi’s Sarcoma-Associated Herpesvirus.
Reviews in Medical Virology 17, 405-422, 2007
 
3. 藤室 雅弘, 横沢 英良
HHV-8感染における遺伝子発現とユビキチンシステムの制御 
蛋白質核酸酵素(ウイルス研究の現在と展望)52, 1113-1120, 2007
 
4. Ochiai H, Fujimuro H, Yokosawa H, Harashima H, Kamiya H.
Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression.
Gene Therapy 14, 1152-1159, 2007
 
5. Ohtawa M, Ichikawa S, Teishikata Y, Fujimuro M, Yokosawa H, Matsuda A. 9-(2-C-Cyano-2-deoxy-beta-d-arabino- pentofuranosyl)guanine, a Potential Antitumor Agent against B-Lymphoma Infected with Kaposi's Sarcoma-Associated Herpesvirus.
J. Med Chem. 50, 2007-2010, 2007
 
6. 藤室 雅弘.
KSHVと発がん 
ウイルス(日本ウイルス学会)56, 209-218, 2006
 
7. Nishiwaki M, Fujimuro M, Teishikata Y, Inoue H, Sasajima H, Nakaso K, Nakashima K, Sadanari H,Yamamoto T, Fujiwara Y, Ogawa N, Yokosawa H.
Epidemiology of Epstein-Barr Virus, Cytomegalovirus and Kaposi’s Sarcoma-Associated Herpesvirus Infections in Peripheral Blood Leukocytes Revealed by a Multiplex PCR Assay.
J. Med. Virol. 78, 1635-1642, 2006
 
8. Fujimuro M, Inoue H, Teishakata Y & Yokosawa H.
Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi’s sarcoma-associated herpesvirus.
Nucleosides, Nucleotides & Nucleic Acids, 25, 635-645, 2006
 
9. Hayward S. D , Liu J, Fujimuro M.
Notch and Wnt Signaling: Mimicry and manipulation by gamma herpesviruses.
Science STKE 335, re4, 2006
 
10. 藤室 雅弘 KSHVと細胞内シグナル伝達 
日本臨床 (ヘルペスウイルス学) 64, 558-563, 2006
 
11. Muromoto R, Okabe K, Fujimuro M, Sugiyama K, Yokosawa H, Seya T and Matsuda T.
Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA.
FEBS lett. 580, 93-98, 2006
 
12. Fujimuro M, Nakaso K, Nakashima K, Sadanari H, Hisanori I, Teishikata Y, Hayward SD,Yokosawa H.
Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV. Exp.
Mol. Pathol. 80, 124-131, 2006
 
13. Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K and Matsuda T.
Physical and functional interactions between Daxx and STAT3
Oncogene, 25: 2131?2136, 2006
 
14. Sato N, Kamada N, Muromoto R, Kawai T, Sugiyama K, Watanabe T, Imoto S, Sekine Y, Ohbayashi N, Ishida M, Akira S and Matsuda T.
Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.
Immunology Letters, 103(2): 127-34. 2006
 
15. Fujimuro M. & Yokosawa H.
Production of antipolyubiquitin monoclonal antibodies and their use for characterization and isolation of polyubiquitinated proteins.
Methods in Enzymol. 399, 75-86, 2005
 
16. Fujimuro M, Nishiya T, Nomura Y, Yokosawa H.
Involvement of Polyubiquitin Chains via Specific Chain Linkages in Stress Response in Mammalian Cells.
Biol. Pharm. Bull. 28, 2315-2318, 2005
 
17. Fujimuro M, Liu J, Zhu J, Yokosawa H, Hayward SD.
Regulation of the Interaction between Glycogen Synthase Kinase 3 and the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen.
J Virology 79, 10429-10441, 2005
 
18. Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A.
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington's Disease.
Neuron 47, 29-41, 2005
 
19. Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Takahashi M, Cheah JH, Tankou SK, Hester LD,Ferris CD, Hayward SD, Snyder SH & Sawa A.
S-Nitrosylated Glyceraldehyde-3-Phosphate Dehydrogenase Initiates Apoptotic Cell Death By Nuclear Translocation Following Siah1 Binding.
Nature Cell Biol. 7, 665-674, 2005
 
20. Tsukamoto S, Hirota H, Imachi M, Fujimuro M, Onuki H, Ohta T & Yokosawa H.
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
Bioorg. Med. Chem. Lett., 15, 191-194, 2005
 
21. Fujimuro M, Hayward S. D.
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
J. Mol. Med., 82, 223-231, 2004
 
22. 藤室雅弘.
The role of Kaposi's sarcoma-associated herpesvirus in oncogenesis.
生化学 76, 140-143, 2004. Review
 
23. Wu F.Y, Wang S.E, Tang Q.Q, Fujimuro M, Chiou C.J, Zheng Q, Chen H, Hayward S.D, Lane M.D & Hayward G.S. 
Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1).
J. Virology, 77, 8893-8914, 2003
 
24. Fujimuro M, Wu F.Y, ApRhys C, Kajumbula H, Young D.B, Hayward G.S & Hayward S.D.
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
Nature Medicine, 9, 300-306, 2003
 
25. Wu F.Y, Chen H, Wang S.E, ApRhys C.M, Liao G, Fujimuro M, Farrell C.J & Huang J, Hayward SD, Hayward GS.
CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.
J. Virology, 77, 1481-1500, 2003
 
26. Wang S.E, Wu F.Y, Fujimuro M, Zong J, Hayward S.D. & Hayward G.S.
Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP.
J. Virology, 77, 600-623, 2003
 
27. Fujimuro M. & Hayward S.D.
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.
J. Virology, 77, 8019-8030, 2003
 
28. Krithivas A, Fujimuro M, Weidner M, Young D.B. & Hayward S.D.
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.
J. Virology, 76, 11596-11604, 2002
 
29. Wu F.Y, Tang Q.Q, Chen H, ApRhys C, Farrell C, Chen J, Fujimuro M, Lane M.D. & Hayward G.S.
Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha.
Proc. Natl. Acad. Sci. USA, 99, 10683-10688, 2002
 
30. Yanagawa Y, Hasezawa S, Kumagai F, Oka M, Fujimuro M, Naito T, Makino T, Yokosawa H, Tanaka K, Komamine A, Hashimoto J, Sato T & Nakagawa H.
Cell-cycle dependent dynamic change of 26S proteasome distribution in tobacco BY-2 cells.
Plant. Cell Physiol., 43, 604-613, 2002
 
31. Chen L, Liao G, Fujimuro M, Semmes O.J & Hayward S.D.
Properties of two EBV Mta nuclear export signal sequences.
Virology, 288, 119-128, 2001
 
32. Zhou S, Fujimuro M, Hsieh J.J, Chen L & Hayward S.D.
A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
J. Virology, 74, 1939-1947, 2000
 
33. Zhou S, Fujimuro M, Hsieh J.J, Chen L, Miyamoto A, Weinmaster G. & Hayward S.D.
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Mol. Cell. Biol., 20, 2400-2410, 2000
 
34. Tone Y, Tanahashi N, Tanaka K, Fujimuro M, Yokosawa H, Toh-e A
Nob1p, a new essential protein, associates with the 26S proteasome of growing Saccharomyces cerevisiae cells.
GENE 243, 37-45, 2000
 
35. Takeuchi J, Fujimuro M, Yokosawa H, Tanaka K & Toh-e A.
Rpn9 is required for efficient assembly of the yeast 26S proteasome.
Mol. Cell. Biol., 19, 6575-6584, 1999
 
36. Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M, Yokosawa H & Nomura Y.
Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production.
J. Biol. Chem., 274, 15875-15882, 1999
 
37. Fujimuro M, Takada H, Saeki Y, Toh-e A, Tanaka K & Yokosawa H.
Growth-dependent change of the 26S proteasome in budding yeast.
Biochem. Biophys. Res. Commun., 29, 818-823, 1998
 
38. Fujimuro M, Tanaka K, Yokosawa H & Toh-e A.
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae.
FEBS Lett., 20, 149-154, 1998
 
39. Fujimuro M, Sawada H & Yokosawa H.
Dynamics of ubiquitin conjugation during heat-shock response revealed by using a monoclonal antibody specific to multi-ubiquitin chains.
Eur. J. Biochem., 249, 427-433, 1997
 
40. Takada K, Nasu H, Hibi N, Tsukada Y, Shibasaki T, Fujise K, Fujimuro M, Sawada H, Yokosawa H & Ohkawa K.
Serum concentrations of free ubiquitin and multiubiquitin chains.
Clin. Chem., 43, 1188-1195, 1997
 
41. Kominami K, Okura N, Kawamura M, DeMartino G.N, Slaughter C.A, Shimbara N, Chung C.H, FujimuroM, Yokosawa H, Shimizu Y, Tanahashi N, Tanaka K & Toh-e A.
Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
Mol. Biol. Cell 8, 171-187, 1997
 
42. Yokosawa H., Fujimuro M., Kawahara H. & Whitaker M.
Activation of the proteasome in embryonic cell cycle.
Proteolysis in Cell Functions (Eds. Hopsu-Havu, V. K. et al ), Biomed. Health Res., 13, 418-422, IOS Press, Amsterdam, 1997.
 
43. Tsurumi C, Shimizu Y, Saeki M, Kato S, Demartino G.N, Slaughter C.A, Fujimuro M, Yokosawa H, Yamasaki M, Hendil K.B, Toh-e A, Tanahashi N & Tanaka K.
cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
Eur. J. Biochem., 239, 912-921, 1996.
 
44. Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski J.Q & Lee V.M.
Lewy bodies: purification from diffuse Lewy body disease brains.
Ann. N. Y. Acad. Sci., 786, 195-205, 1996 42.
 
45. Yokota K, Kagawa S, Shimizu Y, Akioka H, Tsurumi C, Noda C, Fujimuro M, Yokosawa H, Fujiwara T,Takahashi E, Ohba M, Yamasaki M, DeMartino G.N, Slaughter C.A, Toh-e A & Tanaka K.
CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.
Mol. Biol. Cell., 7, 853-870, 1996
 
46. Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski J.Q & Lee V.M.
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
Am. J. Pathol., 148, 1517-1529, 1996
 
47. Takada K, Nasu H, Hibi N, Tsukada Y, Ohkawa K, Fujimuro M, Sawada H & Yokosawa H.
Immunoassay for the quantification of intracellular multi-ubiquitin chains.
Eur. J. Biochem., 233, 42-47, 1995
 
48. Kominami K, DeMartino G.N, Moomaw C.R, Slaughter C.A, Shimbara N, Fujimuro M, Yokosawa H, Hisamatsu H, Tanahashi N, Shimizu Y, Tanahashi N, Tanaka K & Toh-e A.
Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.
EMBO J., 14, 3105-3115, 1995
 
49. Kamiya H, Murata-Kamiya N, Fujimuro M, Kido K, Inoue H, Nishimura S, Masutani C, Hanaoka F,Ohtsuka E.
Comparison of incorporation and extension of nucleotides in vitro opposite 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene.
Jpn. J. Cancer Res., 86, 270-276, 1995.
 
50. Fujimuro M, Sawada H & Yokosawa H.
Production and characterization of monoclonal antibodies specific tomulti-ubiquitin chains of polyubiquitinated proteins.
FEBS Lett., 349, 173-180, 1994
 
51. Sawada H, Muto K, Fujimuro M, Akaishi T, Sawada M.T, Yokosawa H and Goldberg A.L.
Different ratios in 20 S proteasomes and regulatory subunit complexes in two isoforms of the 26 S proteasome purified from rabbit skeletal muscle.
FEBS Lett., 335, 207-212, 1993
 
52. Kamiya H, Sakaguchi T, Murata N, Fujimuro M, Miura H, Ishikawa H, Shimizu M, Inoue H, Nishimura S, Matsukage A, Matsutani C, Hanaoka F and Ohtsuka E.
In vitro replication study of modified bases in ras sequences.
Chem. Pharm. Bull. 40, 2792-2795, 1992