Development of karapinchamine A-related carbazoles with antiproliferative activity against glioblastoma-derived cancer stem cells and blood–brain barrier permeability
Haruka Kawatake, Sakura Ichioka, Yutaro Ohki, Kouta Ugawa, Masaya Mori, Miho Hamai, Chiho Shimadzu, Minami Hara, Tomoe Ohta, Hiromi Ii, Susumu Nakata, Takahiro Matsumoto, Seikou Nakamura
Bioorganic & Medicinal Chemistry Letters 141 130745 2026年7月
2025年度
論文
Constituents with dipeptidyl peptidase-IV inhibitory effect from the flower buds of Rosa rugosa
Seikou Nakamura, Takahiro Matsumoto, Rie Yasui, Toshiki Minamide, Tomoe Ohta, Souichi Nakashima, Hisashi Matsuda
Journal of Asian Association of Schools of Pharmacy 15(1) 1-5 2026年2月
Girinimbine produced in Bergera koenigii callus cultures with antiproliferative activity against glioblastoma stem cells
Tomoe Ohta, Tomomi Shun, Kouta Ugawa, Junko Tsukioka, Tomoka Takami, Seikou Nakamura
Bioscience, Biotechnology, and Biochemistry 90(1) 1-9 2025年11月6日
Qualitative and quantitative analyses, and biological activities of major anthraquinones in Rubia argyi and R. tinctorum
Tomoe Ohta, Junko Tsukioka, Shota Miyanowaki, Souichi Nakashima, Hisashi Matsuda, Seikou Nakamura
Phytochemistry Letters 70 104067 2025年11月3日
Antiproliferative activity against glioblastoma-derived cancer stem cells and blood–brain-barrier permeability of carbazole derivatives from Murraya plants and related synthetic compounds
Kouta Ugawa, Raiki Yamamura, Kaori Yajima, Tomoe Ohta, Seikou Nakamura
Journal of Natural Medicines 79(6) 1361-1371 2025年10月15日
Cynaropicrin Increases [Ca2+]i and Ciliary Beat Frequency in Human Airway Epithelial Cells by Inhibiting SERCA
Nobuhisa Todo, Shigekuni Hosogi, Seikou Nakamura, Kouta Noriyama, Nobuyo Tamiya, Yuki Toda, Masaki Shigeta, Koichi Takayama, Eishi Ashihara
Biological & Pharmaceutical Bulletin 47(12) 2119-2126 2024年12月21日
Chemical structures of polyketides and alkaloids isolated from a culture of fungus Curvularia moringae
Takahiro Matsumoto, Miho Hamai, Yayako Inui, Tomoe Ohta, Tatsusada Yoshida, Naoto Kojima, Hayato Yoshikawa, Raku Kutose, Shiori Ando, Tetsushi Watanabe
Fitoterapia 106263-106263 2024年10月16日
Formation of chalcogen-bonding interactions and their role in the trans–trans conformation of thiourea
Takumi Inoue, Nami Morita, Yui Amijima, Rika Sakai, Shohei Hamada, Seikou Nakamura, Yusuke Kobayashi, Takumi Furuta
Organic & Biomolecular Chemistry 22(26) 5301-5305 2024年6月14日
Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cell
Kousuke Araki, Minami Hara, Shohei Hamada, Takahiro Matsumoto, Seikou Nakamura
Chemical & Pharmaceutical Bulletin 72(2) 200-208 2024年2月20日
2023年度
論文
Production of dihydroisocoumarins by callus induction from Hydrangea macrophylla var. thunbergii leaves
Junko Tsukioka, Tomoka Takami, Yuki Ario, Seikou Nakamura
Chemical & Pharmaceutical Bulletin 71(11) 832-837 2023年11月1日
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells
Masaya Okayama, Takahiro Matsumoto, Takahiro Kitagawa, Seikou Nakamura, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe
Journal of Natural Medicines 78(1) 226-235 2024年1月31日
Quantitative analysis of taxiphyllin, a cyanogenic glycoside, in the leaves of Hydrangea macrophylla var. thunbergii
Junko Tsukioka, Yutaro Ohki, Momona Nakao, Seikou Nakamura
Journal of Natural Medicines 77(4) 978-985 2023年9月30日
Dual Chalcogen-Bonding Interactions for the Conformational Control of Urea
Takumi Inoue, Moe Ota, Yui Amijima, Haru Takahashi, Shohei Hamada, Seikou Nakamura, Yusuke Kobayashi, Takahiro Sasamori,Takumi Furuta
Chemistry - A European Journal 29(60) e202302139 2023年10月26日
Antiproliferative activities of diterpenes from leaves of Isodon trichocarpus against cancer stem cells
Seikou Nakamura, Sachiko Sugimoto, Taichi Yoneda, Akari Shinozaki, Moe Yoshiji, Takahiro Matsumoto, Souichi Nakashima, Hisashi Matsuda
Chemical & Pharmaceutical Bulletin 71(7) 502-507 2023年7月1日
Comparison of growth in Hydrangea macrophylla var. thunbergii grown in different soil pH and quantitative analysis of its sweetness-related constituents
Junko Tsukioka, Seikou Nakamura
Chemical & Pharmaceutical Bulletin 71(5) 368-373 2023年5月1日
総説
Development of functional compounds using chemically unstable compounds obtained from medicinal plants
Seikou Nakamura
Yakugaku Zasshi 144(1) 21-26 2024年1月
New biofunctional effects of oleanane-type triterpene saponins
Hisashi Matsuda, Toshio Morikawa, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa
Journal of Natural Medicines 77(4) 644-664 2023年9月30日
2022年度
論文
Plantainoside B in Bacopa monniera Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ
Aina Fukuda, Souichi Nakashima, Yoshimi Oda, Kaneyasu Nishimura, Hidekazu Kawashima, Hiroyuki Kimura, Takashi Ohgita, Eri Kawashita, Keiichi Ishihara, Aoi Hanaki, Mizuki Okazaki, Erika Matsuda, Yui Tanaka, Seikou Nakamura, Takahiro Matsumoto, Satoshi Akiba, Hiroyuki Saito, Hisashi Matsuda, Kazuyuki Takata
Biological & Pharmaceutical Bulletin 46(2) 320-333 2023年2月1日
One-pot synthesis of carbazoles by a domino reaction using microwave heating and antiproliferative activities of constituents from Murraya plants against cancer stem cells
Kouta Ugawa, Momona Nakao, Chikako Sawada, Takahiro Matsumoto, Takahiro Kitagawa, Yutaro Ohki, Kousuke Araki, Seikou Nakamura
Heterocycles 106(4) 725-733 2023年2月28日
7,8-Dihydroxy-3-(4'-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, Eishi Ashihara
Biochemical and Biophysical Research Communications 638 200-209 2023年1月1日
Effects of piperine, a component of pepper (Piper nigrum), on herpes simplex virus type-1 in Vero cells
Seikou Nakamura, Tomoyo Namura, Yuka Nishimura
Journal of Asian Association of Schools of Pharmacy 11 1-5 2022年9月1日
Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica
Souichi Nakashima, Yoshimi Oda, Moeko Morita, Ayako Ohta, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura
Toxins 14(3) 2022年3月16日
Chemical Structures of Phenylbutanoids From Rhizomes of Zingiber cassumunar
Seikou Nakamura, Junko Iwami, Yutana Pongpiriyadacha, Souichi Nakashima, Hisashi Matsuda, Masayuki Yoshikawa
Natural Product Communications 17(2) 1934578X2210778-1934578X2210778 2022年2月23日
Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds
Taichi Yoneda, Naoto Kojima, Takahiro Matsumoto, Daisuke Imahori, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe, Hisashi Matsuda, Seikou Nakamura
Organic & Biomolecular Chemistry 20(1) 196-207 2022年12月2日
Synthesis of 1-methoxy-1H-indoles with a heterocyclic moiety via unstable indole isothiocyanate by using enzyme from Brassicaceae plant
Kaori Ryu, Seikou Nakamura, Koya Miyagawa, Souichi Nakashima, Hisashi Matsuda
Heterocycles 103(1) 416-424 2021年7月1日
Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of Mauritia flexuosa (Moriche Palm)
Kenchi Miyasaka, Shogo Takeda, Seikou Nakamura, Hisashi Matsuda, Hiroshi Shimoda
Journal of Food Biochemistry 45(1) e13583 2020年12月19日
One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme
Kaori Ryu, Seikou Nakamura, Souichi Nakashima, Hisashi Matsuda
Journal of Natural Medicines 75(2) 308-318 2021月1月3日
Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins
Tomoko Matsumoto, Souichi Nakashima, Seikou Nakamura, Yasunao Hattori, Tomoshige Ando, Hisashi Matsuda
Journal of Natural Medicines 75(2) 381-392 2021年1月23日
Detection of new 3,4-dimethylpyrrole derivatives upon the incubation of exogenous amines with extract of onion (Allium cepa) and crude alliinase from garlic (A. sativum)
Taichi Yoneda, Seikou Nakamura, Shogo Okui, Sayaka Okazaki, Souichi Nakashima, Hisashi Matsuda
Heterocycles 102(11) 2168-2178 2021月9月7日
Effective search of triterpenes with anti-HSV-1 activity using a classification model by logistic regression.
Keiko Ogawa, Seikou Nakamura, Haruka Oguri, Kaori Ryu, Taichi Yoneda, Rumiko Hosoki
Frontiers in Chemistry 9 763794 2021年11月2日
総説
Sulfur-containing compounds from leaves of Allium plants, A. fistulosum, A. schoenoprasum var. foliosum, and A. sativum
Seikou Nakamura, Souichi Nakashima, Hisashi Matsuda
Journal of Asian Association of Schools of Pharmacy 10 1-8 2021年
