研究業績

2024年度

論文

  • Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cell
    Kousuke Araki, Minami Hara, Shohei Hamada, Takahiro Matsumoto, Seikou Nakamura
    Chemical & Pharmaceutical Bulletin 72(2) 200-208 2024年2月20日

2023年度

論文

  • Production of dihydroisocoumarins by callus induction from Hydrangea macrophylla var. thunbergii leaves
    Junko Tsukioka, Tomoka Takami, Yuki Ario, Seikou Nakamura
    Chemical & Pharmaceutical Bulletin 71(11) 832-837 2023年11月1日
  • Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells
    Masaya Okayama, Takahiro Matsumoto, Takahiro Kitagawa, Seikou Nakamura, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe
    Journal of Natural Medicines 78(1) 226-235 2024年1月31日
  • Quantitative analysis of taxiphyllin, a cyanogenic glycoside, in the leaves of Hydrangea macrophylla var. thunbergii
    Junko Tsukioka, Yutaro Ohki, Momona Nakao, Seikou Nakamura
    Journal of Natural Medicines 77(4) 978-985 2023年9月30日
  • Dual Chalcogen-Bonding Interactions for the Conformational Control of Urea
    Takumi Inoue, Moe Ota, Yui Amijima, Haru Takahashi, Shohei Hamada, Seikou Nakamura, Yusuke Kobayashi, Takahiro Sasamori,Takumi Furuta
    Chemistry - A European Journal 29(60) e202302139 2023年10月26日
  • Antiproliferative activities of diterpenes from leaves of Isodon trichocarpus against cancer stem cells
    Seikou Nakamura, Sachiko Sugimoto, Taichi Yoneda, Akari Shinozaki, Moe Yoshiji, Takahiro Matsumoto, Souichi Nakashima, Hisashi Matsuda
    Chemical & Pharmaceutical Bulletin 71(7) 502-507 2023年7月1日
  • Comparison of growth in Hydrangea macrophylla var. thunbergii grown in different soil pH and quantitative analysis of its sweetness-related constituents
    Junko Tsukioka, Seikou Nakamura
    Chemical & Pharmaceutical Bulletin 71(5) 368-373 2023年5月1日

総説

  • Development of functional compounds using chemically unstable compounds obtained from medicinal plants
    Seikou Nakamura
    Yakugaku Zasshi 144(1) 21-26 2024年1月
  • New biofunctional effects of oleanane-type triterpene saponins
    Hisashi Matsuda, Toshio Morikawa, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa
    Journal of Natural Medicines 77(4) 644-664 2023年9月30日

2022年度

論文

  • Plantainoside B in Bacopa monniera Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ
    Aina Fukuda, Souichi Nakashima, Yoshimi Oda, Kaneyasu Nishimura, Hidekazu Kawashima, Hiroyuki Kimura, Takashi Ohgita, Eri Kawashita, Keiichi Ishihara, Aoi Hanaki, Mizuki Okazaki, Erika Matsuda, Yui Tanaka, Seikou Nakamura, Takahiro Matsumoto, Satoshi Akiba, Hiroyuki Saito, Hisashi Matsuda, Kazuyuki Takata
    Biological & Pharmaceutical Bulletin 46(2) 320-333 2023年2月1日
  • One-pot synthesis of carbazoles by a domino reaction using microwave heating and antiproliferative activities of constituents from Murraya plants against cancer stem cells
    Kouta Ugawa, Momona Nakao, Chikako Sawada, Takahiro Matsumoto, Takahiro Kitagawa, Yutaro Ohki, Kousuke Araki, Seikou Nakamura
    Heterocycles 106(4) 725-733 2023年2月28日
  • 7,8-Dihydroxy-3-(4'-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells
    Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, Eishi Ashihara
    Biochemical and Biophysical Research Communications 638 200-209 2023年1月1日
  • Effects of piperine, a component of pepper (Piper nigrum), on herpes simplex virus type-1 in Vero cells
    Seikou Nakamura, Tomoyo Namura, Yuka Nishimura
    Journal of Asian Association of Schools of Pharmacy 11 1-5 2022年9月1日
  • Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica
    Souichi Nakashima, Yoshimi Oda, Moeko Morita, Ayako Ohta, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura
    Toxins 14(3) 2022年3月16日
  • Chemical Structures of Phenylbutanoids From Rhizomes of Zingiber cassumunar
    Seikou Nakamura, Junko Iwami, Yutana Pongpiriyadacha, Souichi Nakashima, Hisashi Matsuda, Masayuki Yoshikawa
    Natural Product Communications 17(2) 1934578X2210778-1934578X2210778 2022年2月23日
  • Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds
    Taichi Yoneda, Naoto Kojima, Takahiro Matsumoto, Daisuke Imahori, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe, Hisashi Matsuda, Seikou Nakamura
    Organic & Biomolecular Chemistry 20(1) 196-207 2022年12月2日

講演

  • 薬用植物から得られる化学的に不安定な成分を使用した機能性化合物の開発研究
    中村誠宏
    日本薬学会第 143 年会 2023年3月27日
  • 薬用食品由来成分を利用した難治性疾患予防・治療薬の開発研究
    中村誠宏
    日本生薬学会第 68 回年会 2022年9月11日

2021年度

論文

  • Synthesis of 1-methoxy-1H-indoles with a heterocyclic moiety via unstable indole isothiocyanate by using enzyme from Brassicaceae plant
    Kaori Ryu, Seikou Nakamura, Koya Miyagawa, Souichi Nakashima, Hisashi Matsuda
    Heterocycles 103(1) 416-424 2021年7月1日
  • Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of Mauritia flexuosa (Moriche Palm)
    Kenchi Miyasaka, Shogo Takeda, Seikou Nakamura, Hisashi Matsuda, Hiroshi Shimoda
    Journal of Food Biochemistry 45(1) e13583 2020年12月19日
  • One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme
    Kaori Ryu, Seikou Nakamura, Souichi Nakashima, Hisashi Matsuda
    Journal of Natural Medicines 75(2) 308-318 2021月1月3日
  • Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins
    Tomoko Matsumoto, Souichi Nakashima, Seikou Nakamura, Yasunao Hattori, Tomoshige Ando, Hisashi Matsuda
    Journal of Natural Medicines 75(2) 381-392 2021年1月23日
  • Detection of new 3,4-dimethylpyrrole derivatives upon the incubation of exogenous amines with extract of onion (Allium cepa) and crude alliinase from garlic (A. sativum)
    Taichi Yoneda, Seikou Nakamura, Shogo Okui, Sayaka Okazaki, Souichi Nakashima, Hisashi Matsuda
    Heterocycles 102(11) 2168-2178 2021月9月7日
  • Effects of glycated proteins on melanin productions (糖化タンパク質がメラニンの生成に与える影響)
    Souichi Nakashima, Yuka Moroto, Maho Yoneyama, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura
    Fragrance Journal (フレグランスジャーナル) 49(11) 46-48 2021月11月15日
  • Effective search of triterpenes with anti-HSV-1 activity using a classification model by logistic regression.
    Keiko Ogawa, Seikou Nakamura, Haruka Oguri, Kaori Ryu, Taichi Yoneda, Rumiko Hosoki
    Frontiers in Chemistry 9 763794 2021年11月2日

総説

  • Sulfur-containing compounds from leaves of Allium plants, A. fistulosum, A. schoenoprasum var. foliosum, and A. sativum
    Seikou Nakamura, Souichi Nakashima, Hisashi Matsuda
    Journal of Asian Association of Schools of Pharmacy 10 1-8 2021年

講演

  • 薬用植物由来成分の生合成中間体に着目した機能性物質の開発研究
    中村誠宏
    徳島大学薬学部大学院講義 (徳島) 2021年11月30日