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   京都薬科大学
　病態薬科学系 薬物治療学分野
　〒607-8414
　京都市山科区御陵中内町5
    TEL：075-595-4679（教授室）
　　　：075-595-4680（研究室）
    Mail：yakuchi [＠] mb.kyoto-phu.ac.jp

業　績（発表論文） PUBLICATIONS

2024年
  • Murayama Y, Tabuchi M, Utsumi D, Naruse K, Tokuyama K, Ikedo A, Morimasa E, Kato S, Matsumoto K. Role of transient receptor potential vanilloid 4 channels in an ovalbumin-induced murine food allergic model. Naunyn Schmiedebergs Arch Pharmacol (2024). doi: 10.1007/s00210-024-02969-0. PMID: 38396155.

 

  • Oka M, Akaki S, Ohno O, Terasaki M, Hamaoka-Tamura Y, Saito M, Kato S, Inoue A, Aoki J, Matsuno K, Furuta K, Tanaka S. Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate. J Pharmacol Exp Ther  389:76-86 (2024). doi: 10.1124/jpet.123.002024. PMID: 38290974.

 

  • Nakamoto T, Matsumoto K, Yasuda H, Mori Y, Kato S. Transient receptor potential melastatin 2 is involved in trinitrobenzene sulfonic acid-induced acute and chronic colitis-associated fibrosis progression in mice. J Pharmacol Sci 154:18-29 (2024). doi: 10.1016/j.jphs.2023.11.004. PMID: 38081680.

2023年
  • Yasuda H, Uno A, Tanaka Y, Koda S, Saito M, Sato EF, Matsumoto K, Kato S. Neutrophil extracellular trap induction through peptidylarginine deiminase 4 activity is involved in 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Naunyn Schmiedebergs Arch Pharmacol (2023)  doi: 10.1007/s00210-023-02800-2. PMID: 37878044.

 

  • Kato S, Onishi S, Sasai M, Yasuda H, Saeki K, Matsumoto K, Yokomizo T. Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin-induced allergic enteritis in mice. Clin Exp Pharmacol Physiol 50: 766-775 (2023). doi: 10.1111/1440-1681.13808. PMID: 37406678. 

 

  • Matsumoto K, Kamide M, Uchida K, Takahata M, Shichiri R, Hida Y, Taniguchi Y, Ohishi A, Tominaga M, Nagasawa K, Kato S. Transient Receptor Potential Ankyrin 1 in Taste Nerve Contributes to the Sense of Sweet Taste in Mice. Biol Pharm Bull 46: 939-945 (2023). doi: 10.1248/bpb.b23-00091. PMID: 37394645.

 

  • Matsumoto K, Sugimoto F, Mizuno T, Hayashi T, Okamura R, Nishioka T, Yasuda, H, Horie S, Kido MA, Kato S. Immunohistochemical characterization of transient
    receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity. Cell Tissue Res 391: 287-303 (2023). doi: 10.1007/s00441-022-03723-9. PMID: 37394645.

 

  • 加藤伸一、松本健次郎、安田浩之、竹中 涼、中村直樹. ショウガ由来ポリフェノールの消化管運動に及ぼす影響. 薬理と治療（Jpn Pharmacol Ther）51: 1667-1675 (2023). ISSN: 0386-3603

2022年
  • S. Jonan, N. Hamouda, A. Fujiwara, T. Fujita, S. Kato, A. Amagase. Alleviative effects of glutamate against chemotherapeutic agent-induced intestinal mucositis. J Physiol Pharmacol 73: 539-546 (2022).
 
  • Toshinori Yoshiokam Misaki Ohashi, Kenjiro Matsumoto, Tomoki Omata, Takumi Hamano, Myuna Yamazaki, Kotaro Okano, Riho Kobayashi, Daiske Yamada, Noriyasu Hada, Shinichi Kato, Akiyoshi Saitoh. Repeated psychoogical stress, chronic vicarious social defeat stress, evokes irritable bowel syndorome-like symptoms in mice. Front Neurosci 16: 993132 (2022).

2021年
  • Takehisa Noguchi, Kyosuke Hidaka, Satsuki Kobayashi, Kenjiro Matsumoto, Makoto Yoshioka, Xin Hu, David J Maloney, Shyh-Ming Yang, Shinichi Kato. A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression. Drug Dev Res 82(8): 1235-1246 (2021).

 

  • Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato. Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice. Sci Rep 11(1): 16276 (2021).

 

  • Aliaa Fouad, Kenjiro Matsumoto, Kikuko Amagase, Hiroyuki Yasuda, Makoto Tominaga, Shinichi Kato. Protective effect of TRPM8 against indomethacin-induced small intestinal injury via the release of calcitonin gene-related peptide in mice. Biol Pharm Bull 44(7): 947-957 (2021).

 

  • Kenjiro Matsumoto,  Minako Suenaga, Yumi Mizutani, Kohei Matsui, Ayano Yoshida, Tomohiro Nakamoto, Shinihi Kato. Role of transient receptor potential vanilloid subtype 2 in lower oesophageal sphincter in rat acid reflux oesophagitis. J Pharmacol Sci 146(3), 125-135 (2021).

2020年
  • Yui Matsumoto, Yukiko Matsuya, Kano Nagai, Kikuko Amagase, Kazuko Saeki, Kenjiro Matsumoto, Takehiko Yokomizo, Shinichi Kato. Leukotriene B4 receptor type 2 (BLT2) accelerates the healing of intestinal lesions by promoting epithelial cell proliferation. J Pharmacol Exp Ther  373: 1-9 (2020).

 

  • Junjie Liua, Kazumi Iwata, Kai Zhu, Misaki Matsumoto, Kenjiro Matsumoto, Nozomi Asaoka, Xueqing Zhang, Masakazu Ibi, Masato Katsuyama, Masato Tsutsui, Shinichi Kato, Chihiro Yabe-Nishimura. NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function. Free Radic Biol Med 147, 90-101 (2020).

 

  • Kenjiro Matsumoto, Ayuka Deguchi, Aoi Motoyoshi, Akane Morita, Urara Maebashi, Tomohiro Nakamoto, Shohei Kawanishi, Mari Sueyoshi, Kaneyasu Nishimura, Kazuyuki Takata, Makoto Tominaga, Tsutomu Nakahara, Shinichi Kato. Role of transient receptor potential vanilloid subtype 4 in the regulation of azoxymethane/dextran sulphate sodium-induced colitis-associated cancer in mice. Eur J Pharmacol 867, 172853 (2020).

 2019年
  • Shinichi Kato, Aoi Takahashi, Mai Shindo, Ayano Yoshida, Tomoe Kawamura, Kenjiro Matsumoto, Bunzo Matsuura. Characterization of the gastric motility response to human motilin and erythromycin in human motilin receptor-expressing transgenic mice. PLoS One 14(2), e0205939 (2019).

 

  • Kenjiro Matsumoto, Akihiro Ohishi, Ken Iwatsuki, Kaho Yamazaki, Satoko Takayanagi, Masahiro Tsuji, Eitaro Aihara, Daichi Utsumi, Takuya Tsukahara, Makoto Tominaga, Kazuki Nagasawa, Shinichi Kato. Transient receptor potential vanilloid 4 mediates sour taste sensing via type Ⅲ taste cell differentiation. Sci Rep 9, 6686 (2019).

 

  • Shinichi Kato, Daichi Utsumi, Kenjiro Matsumoto. G protein-coupled receptor 40 activation ameliorates dextran sulfate sodium-induced colitis in mice via the upregulation of glucagon-likepeptide-2. J Pharmacol Sci 140, 144-152 (2019).

 

  • Kenjiro Matsumoto, Shinichi Kato. Physiological and pathophysiological roles of TRPV4 channel in gastrointestinal tract (消化管におけるtransient receptor potential vanilloidの生理機能と病態における役割). Nihon Yakurigaku Zasshi 154, 92-96 (2019).

 2018年
  • Hiroyasu Sakai, Saori Yabe, Ken Sato, Yuki Kai, Fumiaki Sato, Tetsuo Yumoto, Yuka Inoue, Minoru Narita, Kenjiro Matsumoto, Shinichi Kato, Yoshihiko Chiba. ELR+ chemokine- mediated neutrophil recruitment is involved in 2,4,6- trinitrochlorobenzene-induced contact hypersensitivity. Clin Exp Pharmacol Physiol 45, 27-33 (2018).

 

  • Kenjiro Matsumoto, Riho Yamada, Ken Inoue, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Makoto Tominaga, Shinichi Kato. Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis. Br J Pharmacol 175, 84-99 (2018).

 

  • Daichi Utsumi, Kenjiro Matsumoto, Takuya Tsukahara, Kikuko Amagase, Makoto Tominaga, Shinichi Kato. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P. J Pharmacol Sci 136, 121-132 (2018).

 

  • Kenjiro Matsumoto, Hiroki Kawanaka, Masatoshi Hori, Kosuke Kusamori, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Syunji Horie, Akira Yamamoto, Hiroshi Ozaki, Yasuo Mori, Shinichi Kato. Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus. Am J Physiol Gastrointest Liver Physiol 315, G104-G116 (2018).

 

  • Syunji Horie, Kimihito Tashima, Kenjiro Matsumoto. Gastrointestinal spice sensors and their functions (消化管スパイスセンサーとその機能：辛味は胃腸でも味わう). Yakugaku zasshi 138, 1003-1009 (2018).

 

  • Kenjiro Matsumoto, Shinichi Kato. TRPV4 regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis (マウス炎症性腸疾患モデルにおける血管内皮TRPV4の発現増大と病態への関与). Nihon Yakurigaku Zasshi 152, 170-174 (2018).

 2017年
  • Yokota H, Tsuzuki A, Shimada Y, Imai A, Utsumi D, Tsukahara T, Matsumoto M, Amagase K, Iwata K, Nakamura A, Yabe-Nishimura C, Kato S. NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis. J Pharmacol Exp Ther 360:192-200 (2017).

 

  • Hamouda N, Sano T, Oikawa Y, Ozaki T, Shimakawa M, Matsumoto K, Amagase K, Higuchi K, Kato S. Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5Fluorouracil induced Intestinal Mucositis in Mice. Basic Clin Pharmacol Toxicol 121: 159-168 (2017).

 

  • Sakai H, Sato K, Sato F, Kai Y, Mandokoro K, Matsumoto K, Kato S, Yumoto T, Narita M, Chiba Y. Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling. Inflamm Res 66: 663-678 (2017).

 

  • Sano T, Utsumi D, Amagase K, Matsumoto K, Tominaga M, Higuchi K, Takeuchi T, Kato S. Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons. J Physiol Pharmacol 68: 79-90 (2017).

 

  • Kato S, Hamouda N, Kano Y, Oikawa Y, Tanaka Y, Matsumoto K, Amagase K, Shimakawa M. Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. Clin Exp Pharmacol Physiol 44: 1017-1025 (2017).

 

  • Tsukahara T, Hamouda N, Utsumi D, Matsumoto K, Amagase K, Kato S. G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells. Pharmacol Res 123: 27-39 (2017).

 2016年
  • Daichi Utsumi, Kenjiro Matsumoto, Kikuko Amagase, Syunji Horie, Shinichi Kato: Serotonin/5-hydroxytryptamine-3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis. Br J Pharmacol 173:1835-49 (2016).

 

  • 加藤伸一: 消化管炎症の病態におけるNADPH オキシダーゼ1 (NOX1)の役割. 日薬理誌 147: 18-22 (2016).

 

  • 吉村　崇、内山安里奈、加藤正巳、狩野真由美、佐伯健輔、田中祥之、加藤伸一: ミニブタ潰瘍性大腸炎モデルにおけるメサラジン腸溶錠400mg「サワイ」の治療効果-アサコール錠400mgを対象とした治療学的同等性試験-. 医学と薬学 73: 55-64 (2016).

 

  • Matsumoto K, Takagi K, Kato A, Ishibashi T, Mori Y, Tashima K, Mitsumoto A,Kato S, Horie S. Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity. Exp Neurol 285: 41-50 (2016).

 

  • Matsumoto K, Umemoto H, Mori T, Akatsu R, Saito S, Tashima K, Shibasaki M, Kato S, Suzuki T, Horie S. Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice. Eur J Pharmacol 771: 220-228 (2016)

 2015年
  • Kato S, Hayashi S, Kitahara Y, Nagasawa K, Aono H, Shibata J, Utsumi D, Amagase K, Kadowaki M: Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells. PLoS One 10: e0116213 (2015).

 

  • 天ヶ瀬紀久子、中村英志、加藤伸一、竹内孝治: グルタミン酸の消化管粘膜保護薬としての可能性. 薬学雑誌 135: 779-782 (2015)