研究実績

2020年以降の研究実績はこちら

論　文

  1. 東崎英之、藤田卓也、山本　昌、村西昌三、寺部　亮、松本隆幸、鈴木　勉:　キトサンカプセルを用いた生理活性ぺプチドの大腸特異的送達法の開発　Drug Delivery System 11, 119-124 (1996).
  2. Takuya Fujita, Tadashi Fujita, Keiko Morikawa, Hiroko Tanaka, Osamu Iemura, Akira Yamamoto, andShozo Muranishi : Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergistic effects of acylation and absorption enhancers. Int. J. Pharm. 134, 47-57 (1996).
  3. Shozo Muranishi, Takuya Fujita, Masahiro Murakami and Akira Yamamoto: Lymphatic transfer of macromolecules after intrapulmonary administration in the presence or absence of various absorption enhancers in rats. Pharmazie 51, 331-336 (1996).
  4. Akira Yamamoto, Takuya Fujita and Shozo Muranishi: Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors. J. Control Release 41, 57-67 (1996).
  5. Shinji Gotoh, Reiko Nakamura, Mizue Nishiyama, Ying-Shu Quan, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine. J. Pharm. Sci. 85, 858-862 (1996).
  6. Kohichiro Tanaka, Takuya Fujita, Yoshihiko Yamamoto, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. Biochim. Biophys. Acta 1283, 119-126 (1996).
  7. Shigeki Okumura, Yoshimi Fukuda, Kanae Takahashi, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers. Pharm. Res. 13, 1247-1251 (1996).
  8. Akeo Hagiwara, Toshio Takahashi, kiyoshi Sawai, Chouhei Sakakura, Hiroyuki Tsujimoto, Tsutomu Imanishi, Masaharu Ohgaki, Junya Yamazaki, Shozo Muranishi, Akira Yamamoto and Taakuya Fujita: Pharmacological effects of 5-fluorouracil microspheres on peritoneal carcinomatosis in animals. Br. J. Cancer, 74, 1392-1396 (1996).
  9. Hideyuki Tozaki, Toshio Taniguchi, Akira Yamamoto and Shozo Muranishi: Intestinal absorption of insulin in the absence of intestinal-fluid enzymes. Pharm. Sci. 2, 365-368 (1996).
  10. Akeo Hagiwara, Toshio Takahashi, Kiyoshi Sawai, Chouhei Sakakura, Masakazu Hoshima, Takayuki ohyama, Masaharu Ohgaki, Tsutomu Imanishi, Akira Yamamoto and S. Muranishi: Methotrexate bound to carbon particles used for treating cancers with lymph node metastases in animal experiments and a clinical pilot study. Cancer 78, 2199-2209 (1996).
  11. Akeo Hagiwara, Chouhei Sakakura, Hiroyuki Tsujimoto, Masaharu Ohgaki, Tsutomu Imanishi, Junya Yamasaki, Kiyoshi Sawai, Toshio Takahashi, Akira Yamamoto and Shozo. Muranishi,Yasuhiko Tabata, Yoshihito Ikada: New formulations of 5-fluorouracil in microsheres reduces toxicity in mice. Anti-Cancer Drugs 7, 780-784 (1996).
  12. Akira Yamamoto, Tomomi Uchiyama, Reiko Nishikawa, Takuya Fujita and Shozo Muranishi,Yasuhiko Tabata, Yoshihiko Ikada: Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: Effect of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipid from the intestinal membrane. J. Pharm. Pharmacol. 48, 1285-1289 (1996).
  13. Tomomi Uchiyama, Akira Yamamoto, Harumi Hatano, Takuya Fujita and Shozo Muranishi: Effectiveness and toxicity screening of various absorption enhancers in the large intestine: Intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane. Biol. Pharm. Bull. 19, 1618-1621 (1996).

プロシーディングス

  1. Akira Yamamoto, Hideyuki Tozaki, Takuya Fujita, Shozo Muranishi, Akira Terabe, Takayuki Matsumoto, Tsutomu Suzuki:Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. 日本MRS学会講演要旨集 pp.74 (1996).
  2. Akira Yamamoto: Improvement of intestinal absorption of biologically active peptides by chemical modification with fatty acids. Drug Delivery System 11, pp.246 (1996).
  3. Shozo Muranishi: Chitosan capsules for colon-specific delivery: Improvement of insulin absorption from the rat colon. Drug Delivery System 11, pp.255 (1996).
  4. Hidenori Yamada, Masaki Fukuzumi, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Efflux mechanism of calcein from intestinal mucosal membrane. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 251-252, (1996).
  5. Tomomi Uchiyama, Tetsuo Sugiyama, Ken Eisyuku, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Enhancement effect of various absorption enhancers on the transport of insulin across the intestinal membrane. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 429-430 (1996).
  6. Takuya Fujita, I-ichiro Kawahara, Akira Yamamoto and Shozo Muranishi: Assessment of transport characteristics of tetragastrin and its acyl-derivatives across the intestinal mucosal membrane using Caco-2 cell monolayers. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 431-432 (1996).
  7. Shigeki Okumura, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 443-444 (1996).
  8. Hideyuki Tozaki, Takuya Fujita, Akira Yamamoto, Shozo Muranishi, Tetsuo Sugiyama, Akira Terabe, Takayuki Matsumoto and T. Suzuki: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 551-552 (1996).
  9. Tomoko Ueyama, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Metabolism and excretion mechanisms of aminobenzoic acids in the intestinal mucosal membrane. Proc. Int. Symp. Controlled Release Bioact. Mater. 23, 597-598 (1996).
  10. Akira Yamamoto: Control of intestinal absorption of peptide and protein drugs by chemical modification and protease inhibitors. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, pp.17 (1996).
  11. 山本　昌、瀬藤一成、城之下賢、村上正裕、村西昌三：脂肪酸修飾および超音波照射によるペプチドの皮膚透過性の改善　薬物動態　11(Suppl.), S88-89 (1996).
  12. 山本　昌：生理活性ペプチドの経粘膜吸収の制御　第１８回生体膜と薬物の相互作用シンポジウム講演要旨集　pp.9-12 (1996).
  13. Masahiro Murakami, Lynda S. Welge, Lawrence Lesko and Gordon L. Amidon: Methodology for evaluating intestinal drug permeability: Cyclosporin A as a model water-insoluble drug. 第１８回生体 膜と薬物の相互作用シンポジウム要旨集　pp.199-202 (1996).

学会発表

  1. 城之下賢、鉾谷智子、藤田卓也、山本　昌、村西昌三：超音波による薬物の経皮吸収性改善に関する基礎的検討　日本薬学会第１１６年会（金沢）, (1996) 3.
  2. 上山智子、亘美穂子、大前隆広、赤代恵子、藤田卓也、山本　昌、村西昌三：消化管粘膜におけるパラアミノ安息香酸の代謝・排泄機構に関する研究　日本薬学会第１１６年会（金沢 ）, (1996) 3
  3. 山田秀徳、西牧明日香、福澄正規、藤田卓也、山本　昌、村西昌三：消化管粘膜からのcalcein分泌機構に関する検討　日本薬学会第１１６年会（金沢）, (1996) 3
  4. 河原亥一郎、竹中佳代、服部康二、藤田卓也、山本　昌、村西昌三：Caco-2細胞を用いたテトラガストリンおよびそのアシル化誘導体の消化管粘膜透過性の評価　日本薬学会第１１６年会（金沢）,(1996) 3.
  5. 小谷敦史、内山知実、杉山徹夫、権　英淑、藤田卓也、山本　昌、村西昌三：インスリン・エンケファリンの消化管粘膜透過性に及ぼす各種添加剤及び化学修飾の効果　日本薬学会第１１６年会（金沢）,(1996) 3.
  6. 内山知実、後藤新治、笠間久代、吉田拓生、藤田卓也、山本　昌、村西昌三：水溶性薬物の粘膜透過性に及ぼすタンパク分解酵素阻害剤の影響　日本薬学会第１１６年会（金沢）, (1996) 3.
  7. 東崎英之、小茂池潤太、多田知加、圓山貴子、藤田卓也、山本　昌、村西昌三、金　淳二、寺島　宏：アゾポリマーでコーティングした製剤を用いたインスリンの大腸特異的送達法の開発　日本薬学会第１１６年会（金沢）, (1996) 3.
  8. 奥村茂樹、高瀬佳要、藤田卓也、山本　昌、村西昌三：アフリカツメガエル肺組織を用いたインスリンのin vitro肺組織透過性の検討　日本薬学会第１１６年会（金沢）, (1996) 3.
  9. 藤田卓也、後藤新治、渡邊利昌、尾山祐次郎、八塚麻紀、吉見啓子、山本　昌、村西昌三、Kim, K.J. ：ラット肺初代培養系を用いたインスリンの経肺吸収性評価　日本薬学会第１１６年会（金沢）,(1996) 3.
  10. Shozo Muranishi: Modification of peptides for improvement of intestinal delivery. 韓国薬剤学会シンポジウム, Seoul, (1996) 5.
  11. 山本　昌、東崎英之、藤田卓也、村西昌三、寺部　亮、松本隆幸、鈴木　：キトサンカプセルを用いた大腸特異的送達法によるインスリンの吸収改善　日本MRSシンポジウム（千葉）, (1996) 5.
  12. Akira Yamamoto: Improvement of intestinal absorption of biologically active peptides by chemical modification with fatty acids. 第１２回日本DDS学会（京都）, (1996) 7.
  13. Shozo Muranishi: Chitosan capsules for colon-specific delivery: Improvement of insulin absorption from the rat colon. 第１２回日本DDS学会（京都）,(1996) 7.
  14. Masaru Shironoshita, Ken-ichi Kitaoka, Atsuko Kitamori, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Transdermal drug delivery by sonophoresis: Effects of intensity, duration, and mode of ultrasound exposure. 第１２回日本DDS学会（京都）, (1996) 7.
  15. Masaki Fukuzumi, Hidenori Yamada, Asuka Nishimaki, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Efflux mechanism of calcein mediated by non-p-glycoprotein from the intestinal mucosal membrane. 第１２回日本DDS学会（京都）, (1996) 7.
  16. Tomoko Ueyama, Mihoko Watari, Takahiro Ohmae, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Metabolism and excretion mechanisms of p-aminobenzoic acids in the intestinal mucosal membrane. 第１２回日本DDS学会（京都）, (1996) 7.
  17. Junya Yamasaki, Toshio Takahashi, Akeo Hagiwara, Masaharu Ohgaki, Shozo Muranishi, Akira Yamamoto, Yoshihito Ikada and Yasuhiko Tabata: Treatment of peritoneal carcinomatosis using microspheres incorporating 5-fluorouracil. 第１２回日本DDS学会（京都）, (1996) 7.
  18. Shigeki Okumura, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various additives. 第１２回日本DDS学会（京都）,(1996) 7.
  19. Toshiaki Watanabe, Shinji Goto, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Transport characteristics of insulin across the primary cultured monolayers of rat alveolar epithelial cells. 第１２回日本DDS学会（京都）, (1996) 7.
  20. Junta Komoike, Hideyuki Tozaki, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon.第１２回日本DDS学会（京都）, (1996) 7.
  21. Tomomi Uchiyama, Tetsuo Sugiyama, Ying-shu Quan, Atsushi Kotani, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Enhancement effects of various absorption enhancers on the transport of insulin across the intestinal membrane in rats. 第１2回日本DDS学会（京都）, (1996) 7.
  22. Koji Hattori, Ichiro Kawahara, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Assesment of transport characteristics of tetragastrin and its acyl-derivatives across the intestinal mucosal membrane using Caco-2 cell monolayers. 第１2回日本DDS学会（京都）, (1996) 7.
  23. Daisuke Kuribayashi, Yutaka Morishita, Hitomi Ito, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Intestinal transport mechanisms of phenylalanyl-glycine(Phe-Gly) by chemical modification with fatty acids. 第１2回日本DDS学会（京都）, (1996) 7.
  24. Hidenori Yamada, Masaki Fukuzumi, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Efflux mechanism of calcein from intestinal mucosal membrane. 23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  25. Tomomi Uchiyama, Tetsuo Sugiyama, Ken Eisyuku, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Enhancement effect of various absorption enhancers on the transport of insulin across the intestinal membrane. 23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  26. Takuya Fujita, I-ichiro Kawahara, Akira Yamamoto and Shozo Muranishi: Assessment of transport characteristics of tetragastrin and its acyl-derivatives across the intestinal mucosal membrane using Caco-2 cell monolayers. 23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  27. Shigeki Okumura, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers.23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  28. Hideyuki Tozaki, Takuya Fujita, Akira Yamamoto, Shuzo Muranishi, Tetsuo Sugiyama, Akira Terabe, Takayuki Matsumoto and Tsutomu Suzuki: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon.23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  29. Tomoko Ueyama, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Metabolism and excretion mechanisms of aminobenzoic acids in the intestinal mucosal membrane. 23rd Int. Symp. Controlled Release Bioact. Mater., Kyoto , (1996) 7.
  30. Akira Yamamoto: Control of intestinal absorption of peptide and protein drugs by chemical modification and protease inhibitors. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle , (1996) 7.
  31. Shigeki Okumura, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by absorption enhancers. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle , (1996) 7.
  32. Tetsuo Sugiyama, Tomomi Uchiyama, Ying-shu Quan, Atsushi Kotani, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi: Enhancement effects of various absorption enhancers on the transport of insulin across the intestinal membrane in rats. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle , (1996) 7.
  33. Hideyuki Tozaki, Takuya Fujita, Akira Yamamoto, Akira Terabe, Takayuki Matsumoto, Tsutomu Suzuki and Shozo Muranishi: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle , (1996) 7.
  34. Tomoko Ueyama, Takuya Fujita, Akira Yamamoto and Shozo Muranishi: Metabolism and excretion mechanisms of p-aminobenzoic acids in the intestinal mucosal membrane. 8th Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle , (1996) 7.
  35. 山本　昌、瀬藤一成、城之下賢、村上正裕、村西昌三：脂肪酸修飾および超音波照射によるペプチドの皮膚透過性の改善　第１１回日本薬物動態学会年会（金沢）, (1996) 10.
  36. 栗林大輔、笠間久代、吉田拓生、中本優子、山本　昌、村西昌三：水溶性薬物の粘膜透過性に及ぼす各種タンパク分解酵素阻害剤の影響　第１１回日本薬物動態学会年会（金沢）, (1996) 10.
  37. 小谷敦史、内山知実、岸田剛志、巽　浩幸、岡本　彩、村上正裕、山本　昌、村西昌三：エンケファリンの消化管粘膜透過、安定性に及ぼす化学修飾及び各種添加剤の影響　第１１回日本薬物動態学会年会（金沢）, (1996) 10.
  38. 躍場朋和、井関智弥、倉田美希、山本　昌、村西昌三：消化管各部位における各種タンパク分酵素活性の評価ならびに生理活性ペプチドの安定性、吸収性との関連　第１１回日本薬物動態学会年会（金沢）, (1996) 10.
  39. 内山知実、小谷敦史、杉山徹夫、権　英淑、村上正裕、山本　昌、村西昌三：In vitro Ussing chamber を用いたインスリンの消化管粘膜透過性に及ぼす各種吸収促進剤の影響 第１１回 日本薬物動態学会年会（金沢）, (1996) 10.
  40. 山田秀徳、福澄正規、木村　豪、杉山真紀、続　正芳、西岡純子、藤田卓也、山本　昌、村西昌三：消化管粘膜からの有機アニオン排出機構に関する研究　第１１回日本薬物動態学会年会（金沢）,(1996) 10.
  41. 上山智子、大前隆広、正野泰士、山田恵理子、藤田卓也、山本　昌、村西昌三：ラット小腸粘膜におけるアセトアミノ安息香酸の排出機構に関する研究　第１１回日本薬物動態学会年会（金沢）, (1996) 10.
  42. 山本　昌：生理活性ペプチドの経粘膜吸収の制御　第１８回生体膜と薬物の相互作用シンポジウム（徳島）, (1996) 11.
  43. Masahiro Murakami, Lynda S. Welge, Lawrence Lesko and Gordon L. Amidon: Methodology for evaluating intestinal drug permeability: Cyclosporin A as a model water-insoluble drug. 第１８回生体膜と薬物の相互作用シンポジウム（徳島）, (1996) 11.
  44. 小谷敦史、内山知実、村上正裕、山本　昌、村西昌三：化学修飾および添加剤併用によるエンケファリン誘導体の消化管粘膜透過性の改善　第１８回生体膜と薬物の相互作用シンポジウム（徳島）, (1996) 11.

その他

  1. 山本　昌：生理活性ペプチドの経粘膜吸収改善に関する研究　－奨励賞受賞講演－　第１１回日本薬物動態学会年会（金沢）, (1996) 10.