Kyoto Pharmaceutical University, Division of Medicinal Chemical Sciences, Department of Pharmaceutical Manufacturing Chemistry

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Naoto Kojima

Educational background

在学期間 学校名
1992年4月1日～1995年3月31日 大阪府立北野高等学校　普通科 卒業
1995年4月1日～1999年3月31日 大阪大学　薬学部　製薬化学科 卒業
1999年4月1日～2001年3月31日 大阪大学大学院　薬学研究科　分子薬科学専攻　博士前期課程 修了
2001年4月1日～2004年3月31日 大阪大学大学院　薬学研究科　分子薬科学専攻　博士後期課程 修了

Work history

期間 勤務先　及び　職名
2002年4月1日～2004年3月31日 日本学術振興会　特別研究員（DC2）
2004年4月1日～2005年8月31日 公益財団法人　相模中央化学研究所　研究員
2005年9月1日～2007年3月31日 大阪大学大学院　薬学研究科　助手
2007年4月1日～2012年3月31日 大阪大学大学院　薬学研究科　助教
2012年4月1日～2017年3月31日 京都薬科大学　講師
2017年4月1日～現在 京都薬科大学　准教授

Patents

  1. 新規なＡＭＰ活性化プロテインキナーゼ活性化剤
    2021年6月4日
    特願2021-094481
  2. ヒトのがん細胞の増殖を抑制するための化合物及び医薬
    2013年8月1日
    特開2013-147453
  3. 新規ベンゾイソフラノン誘導体による臓器組織の修復再生治療薬
    2012年9月10日
  4. 5,6-ジヒドロ-5-トリフルオロメチルウラシルの分解方法
    2007年3月29日
    特開2007-74953
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Original article

  1. Kaito Ohta, Tetsuya Fushimi, Mutsumi Okamura, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety, RSC Advances,12, 15728–15739 (2022).

  2. Shota Ando, Naoto Kojima, Chiami Moyama, Mitsugu Fujita, Kaito Ohta, Hiromi Ii, Susumu Nakata,* JCI-20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels, Mol. Med. Rep., 26, 238, (2022).

  3. Shota Ando, Chiami Moyama, Naoto Kojima, Mitsugu Fujita, Kaito Ohta, Yukina Kohno, Hiromi Ii, Susumu Nakata,* JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells, Biochem. Biophys. Res. Commun., 591, 62–67 (2022).

  4. Takahiro Μatsumoto, Daisuke Imahori, Erika Ohnishi, Masaya Okayama, Takahiro Kitagawa, Tomoe Ohta, Tatsusada Yoshida, Naoto Kojima, Masayuki Yamashita, Tetsushi Watanabe,* Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum, Fitoterapia, 156, 105097 (2022).

  5. Taichi Yoneda, Naoto Kojima, Takahiro Matsumoto, Daisuke Imahori, Tomoe Ohta, Tasusada Yoshida, Tetsushi Watanabe, Hisashi Matsuda, Seikou Nakamura,* Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds, Org. Biomol. Chem., 20, 196–207 (2022).

  6. Kaito Ohta, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Structure-activity relationships of thiophene carboxamide annonaceous acetogenin analogs: Shortening the alkyl chain in the tail part significantly affects their growth inhibitory activity against human cancer cell lines, Chem. Pharm. Bull., 69, 1029–1033 (2021).

  7. Aya Niki, Minoru Ozeki,* Akiko Kuse, Shiho Nakagawa, Syui Aoki, Takashi Shigeta, Tetsuya Kajimoto, Hiroki Iwasaki, Naoto Kojima, Kenji Arimitsu, Shinzo Hosoi, Manabu Node, Masayuki Yamashita, Ikuo Kawasaki,* Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine, Chem. Pharm. Bull., 69, 926–930 (2021).

  8. Takahiro Matsumoto, Takahiro Kitagawa, Daisuke Imahori, Hayato Yoshikawa, Masaya Okayama, Mayuka Kobayashi, Naoto Kojima, Masayuki Yamashita, Tetsushi Watanabe,* Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei, J. Nat. Med., 75, 942–948 (2021).

  9. Yun-Han Hsieh, Hiroki Iwasaki, Yumina Iwai, Yuki Tanabe, Rinako Taketomo, Suzuna Yamanishi, Yuichiro Tanaka, Naoto Kojima, Masayuki Yamashita,* Reaction of 3-Oxa-2-oxobicyclo[4.2.0]oct-4-ene-1-carboxylate with Dimethylsulfoxonium Methylide, Chem. Pharm. Bull., 69, 391–399 (2021).

  10. Yun-Han Hsieh, Hiroki Iwasaki, Yumina Iwai, Miki Adachi, Kanako Kitai, Eri Kuribayashi, Yuri Hirata, Suzuna Sakaguchi, Naoko Sakaguchi, Naoto Kojima, Masayuki Yamashita,* [2+2]Photocycloaddition of 5,6-Substituted 2-Oxo-2H-pyran-3-carboxylates with Alkenes, Heterocycles, 102, 254–273 (2021).

  11. Naoto Kojima,* Hiromi Hayashi, Hiroki Iwasaki, Masayuki Yamashita, Syntheses of C2′-Fluorinated Analogs of Solamin, Chem. Pharm. Bull., 68, 675–678 (2020).

  12. Toshio Fujiwara, Yuka Taniguchi, Yuri Kokuryu, Yuumi Baba, Daiki Kawano, Yuuki Kawakami, Shouta Suzuki, Yukiteru Katsumoto, Minoru Ozeki, Hiroki Iwasaki, Ichiro Takahashi, Naoto Kojima, Masayuki Yamashita,* Shinzo Hosoi,* Application of a novel chromophoric reagent, 2,2′-binaphthyl-3,3′-dicarbonyl cyanide, to the absolute configuration determination of chiral secondary alcohols, Tetrahedron Lett., 61, 151984 (2020).

  13. Takahiro Μatsumoto, Daisuke Imahori, Kaduki Achiwa, Youhei Saito, Tomoe Ohta, Tatsusada Yoshida, Naoto Kojima, Masayuki Yamashita, Yuji Nakayama, Tetsushi Watanabe,* Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus, Fitoterapia, 142, 104524 (2020).

  14. Takuya Matsumoto, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Synthesis and cancer cell growth inhibition effects of acetogenin analogs bearing ethylene glycol units for enhancing the water solubility, Tetrahedron, 76, 131058 (2020).

  15. Toru Tanaka, Shoki Inoue, Takuya Miura, Yun-Han Hsieh, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* FACILE PEPARATION OF 2-OXO-2H-1-PYRAN-3-CARBOXYLATES WITH THE ELECTRON-WITHDRAWING GROUP AT THE 5-POSITION, Heterocycles, 100, 429–439 (2020).

  16. Shingo Ueno, Park Pyoyun, Yukio Tosa, Takashi Maoka, Naoto Kojima, Masayuki Yamashita, Masafumi Inoue,* Tamio Ueno, Mosquito larvicidal and antifungal isoquinoline alkaloids from Papaverraceae, Jpn. J. Environ. Entomol. Zool., 30, 51–61 (2019).

  17. Minoru Ozeki,* Ayumi Hachino, Takashi Shigeta, Aya Niki, Natsuko Kobayashi, Hideki Mizutani, Akihiro Nakamura, Ayano Horie, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Masayuki Yamashita, Ikuo Kawasaki,* A facile and convenient synthesis of trisubstituted (E)-α,β-unsaturated esters by tandem acetylation-E1cB reaction, Chem. Pharm. Bull., 67, 71–74 (2019).

  18. Daisuke Imahori, Takahiro Matsumoto, Naoto Kojima, Tomohiro Hasei, Megumi Sumii, Taishi Sumida, Masayuki Yamashita, Tetsushi Watanabe,* Chemical structures of novel maillard reaction products under hyperglycemic conditions, Chem. Pharm. Bull., 66, 363–367 (2018).

  19. Takahiro Matsumoto, Seikou Nakamura, Naoto Kojima, Tomohiro Hasei, Masayuki Yamashita, Tetsushi Watanabe,* Hisashi Matsuda, Antimutagenic activity of ent-kaurane diterpenoids from the aerial parts of Isodon japonicus, Tetrahedron Lett., 58, 3574–3578 (2017).

  20. Takuya Matsumoto, Naoto Kojima,* Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines, Tetrahedron, 73, 2359–2366 (2017).

  21. Minoru Ozeki,* Honoka Egawa, Toshiki Takano, Hideki Mizutani, Narumi Yasuda, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Novel and practical asymmetric synthesis of β2,3-amino esters using asymmetric Michael addition of chiral amine, Tetrahedron, 73, 2014–2021 (2017).

  22. Shinji Kobuchi, Megumi Matsuno, Momoko Kawamoto, Naoto Kojima, Yukako Ito, Masayuki Yamashita, Toshiyuki Sakaeda,* A simple and rapid LC-MS/MS method for quantitation of luseogliflozin in rat plasma and its application to a PK study, Bioanalysis, 9, 163–171 (2017).

  23. Toru Tanaka, Masaki Nagahama, Navnath Dnyanoba Yadav, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* SKELETAL TRANSFORMATION OF 2a,8b-DIHYDROBENZO[b]CYCLOBUTE[d]PYRAN-3-ONES INTO DIHYDRODIBENZOFURANS, Heterocycles, 92, 1665–1673 (2016).

  24. Akinobu Akatsuka, Naoto Kojima, Mutsumi Okamura, Shingo Dan, Takao Yamori,* A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I, Pharma. Res. Per., 4, e00246(2016).

  25. Minoru Ozeki,* Noboru Hayama, Shintaro Fukutome, Honoka Egawa, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Construction of Seven Contiguous Chiral Centers by Two Methods: Quadruple Michael Addition vs Stepwise Double-Double Michael Addition Controlled by Adding Speed of Michael Acceptor, ChemistrySelect, 1, 2565–2569(2016).

  26. Toru Tanaka, Masaki Nagahama, Navnath Dnyanoba Yadav, Hiroyuki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Reaction of 2a,8b-dihydrobenzo[b]cyclobute[d]pyran-3-ones with dimethylsulfoxonium methylide, Chem. Pharm. Bull., 64, 1056–1061(2016).

  27. Shushi Nagamori, Pattama Wiriyasermkul, Suguru Okuda, Naoto Kojima, Yoshiyuki Hari, Shigeki Kiyonaka, Yasuo Mori, Hideyuki Tominaga, Ryuichi Ohgaki, Yoshikatsu Kanai,* Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling, Amino Acids, 48, 1045–1058(2016).

  28. Toru Tanaka, Takuya Miura, Shoki Inoue, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Skeletal transformation of α-pyrones having electron-withdrawing groups at 3,5-positions into ring-fused dihydrofurans, Tetrahedron Lett., 56, 6327–6331 (2015).

  29. Minoru Ozeki,* Honoka Egawa, Akiko Kuse, Toshiki Takano, Narumi Yasuda, Hideki Mizutani, Sumire Izumiya, Daichi Nakashima, Kenji Arimitsu, Takuya Miura, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Practical and highly stereoselective synthesis of trisubstituted (E)-α,β-unsaturated esters, Synthesis, 47, 3392–3402 (2015).

  30. Kenji Suzuki, Hiroki Iwasaki, Reika Domasu, Naho Hitotsuyanagi, Yuka Wakizaka, Mao Tominaga, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Construction of pyrrolophenanthridinone scaffolds mediated by samarium(II) diiodide and access to natural product synthesis, Tetrahedron, 71, 5513–5519 (2015).

  31. Kenji Suzuki, Hiroki Iwasaki, Fumihito Ichiyoshi, Mao Tominaga, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Synthesis of 3-ethenylindoles via intramolecular cyclization of aryl radical with allene generated by samarium(II) diiodide, Heterocycles, 91, 1244–1255 (2015).

  32. Shinzo Hosoi, Minoru Ozeki,* Masashi Nakano, Kenji Arimitsu, Tetsuya Kajimoto, Naoto Kojima, Hiroki Iwasaki, Takuya Miura, Hiroyuki Kimura, Manabu Node, Masayuki Yamashita,* Mechanistic aspects of asymmetric intramolecular Heck reaction involving dynamic kinetic resolution: flexible conformation of the cyclohexenylidene–benzene system, Tetrahedron, 71, 2317–2326(2015).

  33. Naoto Kojima,* Yuki Suga, Takuya Matsumoto, Tetsuaki Tanaka, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines, Bioorg. Med. Chem., 23, 1276–1283 (2015).

  34. Naoto Kojima,* Tetsuya Fushimi, Takahiro Tatsukawa, Tetsuaki Tanaka, Mutsumi Okamura, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead, Eur. J. Med. Chem., 86, 684–689 (2014).

  35. Takuya Miura, Saki Fujioka, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Skeleton transformation of α-pyrone induced by 5-aryl substituent into ring-fused dihydrofuran, Tetrahedron Lett., 55, 1536–1539 (2014).

  36. Takuya Miura, Saki Fujioka, Naoto Takemura, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Synthesis of 6-subtituted 3-(alkoxycarbonyl)-5-aryl-α-pyrones, Synthesis, 46, 496–502 (2014).

  37. Hiroki Iwasaki, Kenji Suzuki, Mitsunari Yamane, Shohei Yoshida, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide, Org. Biomol. Chem., 12, 6812–6815 (2014).

  38. Naoto Kojima,* Tetsuya Fushimi, Takahiro Tatsukawa, Takehiko Yoshimitsu, Tetsuaki Tanaka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Structure–activity relationships of hybrid annonaceous acetogenins: powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines, Eur. J. Med. Chem., 63, 833–839(2013).

  39. Minoru Ozeki,* Megumi Satake, Toshinori Toizume, Shintaro Fukutome, Kenji Arimitsu, Shinzo Hosoi, Tetsuya Kajimoto, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* First asymmetric total synthesis of (+)-taiwaniaquinol D and (-)-taiwaniaquinone D by using intramolecular Heck reaction, Tetrahedron, 69, 3841–3846 (2013).

  40. Naoto Kojima,* Masato Abe, Yuki Suga, Kazufumi Ohtsuki, Tetsuaki Tanaka, Hiroki Iwasaki, Masayuki Yamashita, Hideto Miyoshi,* Critical role of a methyl group on the γ-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I, Bioorg. Med. Chem. Lett., 23,1217–1219 (2013).

  41. Takuya Miura, Navnath Dnyanoba Yadav, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Novel skeleton transformation reaction of α-pyrone derivatives to spirobicyclo[3.1.0]hexane derivatives using dimethylsulfoxonium methylide, Org. Lett., 14, 6048–6051(2012).

  42. Hiroaki Ohno,* Mutsumi Iuchi, Naoto Kojima, Takehiko Yoshimitsu, Nobutaka Fujii, Tetsuaki Tanaka,* Double C-H functionalization in sequential order: direct synthesis of polycyclic compounds by a palladium-catalyzed C-H alkenylation-arylation cascade, Chem. Eur. J., 18, 5352–5360 (2012).

  43. Naoto Kojima,* Yuki Suga, Hiromi Hayashi, Takao Yamori, Takehiko Yoshimitsu, Tetsuaki Tanaka,* Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines, Bioorg. Med. Chem. Lett., 21, 5745–5749(2011).

  44. Naoto Kojima,* Shogo Nishijima, Kaoru Tsuge, Tetsuaki Tanaka,* Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives, Org. Biomol. Chem., 9,4425–4428 (2011).

  45. Naoto Kojima,* Takekuni Morioka, Daisuke Urabe, Masahiro Yano, Yuki Suga, Naoyoshi Maezaki, Ayako Ohhashi-Kobayashi, Yasuyuki Fujimoto, Masatomo Maeda, Takao Yamori, Takehiko Yoshimitsu, Tetsuaki Tanaka,* Convergent synthesis of fluorescence-labeled probes of annonaceous acetogenins and visualization of their cell distribution, Bioorg. Med. Chem., 18, 8630–8641 (2010).

  46. Takehiko Yoshimitsu,* Naoya Fukumoto, Ryo Nakatani, Naoto Kojima, Tetsuaki Tanaka, Asymmetric total synthesis of (+)-hexachlorosulfolipid, a cytotoxin isolated from adriatic mussels, J. Org. Chem., 75, 5425–5437 (2010).

  47. Naoto Kojima,* Shogo Nishijima, Tetsuaki Tanaka,* One-pot, three-component synthesis of chiral 4-alkylidene-2-oxazolidinones, Synlett, 3171–3174 (2009).

  48. Naoto Kojima,* Takekuni Morioka, Masahiro Yano, Yuki Suga, Naoyoshi Maezaki, Tetsuaki Tanaka,* Convergent synthesis of fluorescence labeled solamin, Heterocycles, 79, 387–393 (2009).

  49. Naoto Kojima,* Hiromi Hayashi, Satoshi Suzuki, Hiroaki Tominaga, Naoyoshi Maezaki, Tetsuaki Tanaka,* Takao Yamori, Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines, Bioorg. Med. Chem. Lett., 18, 6451–6453(2008).

  50. Naoto Kojima,* Tetsuya Fushimi, Naoyoshi Maezaki, Tetsuaki Tanaka,* Takao Yamori, Synthesis of hybrid acetogenins, α,β-unsaturated-γ-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines, Bioorg. Med. Chem. Lett., 18, 1637–1641 (2008).

  51. Naoyoshi Maezaki, Daisuke Urabe, Masahiro Yano, Hiroaki Tominaga, Takekuni Morioka, Naoto Kojima, Tetsuaki Tanaka,* Synthesis of fluorescent solamin for visualization of cell distribution, Heterocycles, 73, 159–164 (2007).

  52. Hiroaki Tominaga, Naoyoshi Maezaki,* Minori Yanai, Naoto Kojima, Daisuke Urabe, Risa Ueki, Tetsuaki Tanaka,* First total synthesis of longimicin D, Eur. J. Org. Chem., 1422–1429 (2006).

  53. Naoyoshi Maezaki, Hiroaki Tominaga, Naoto Kojima, Minori Yanai, Daisuke Urabe, Risa Ueki, Tetsuaki Tanaka,* Takao Yamori, Total synthesis of murisolins and evaluation of tumor growth-inhibitory activity, Chem. Eur. J., 11, 6237–6245 (2005).

  54. Naoyoshi Maezaki, Hiroaki Tominaga, Naoto Kojima, Minori Yanai, Daisuke Urabe, Tetsuaki Tanaka,* First total synthesis of murisolin, Chem. Commun., 406–407 (2004).

  55. Naoto Kojima, Naoyoshi Maezaki, Hiroaki Tominaga, Minori Yanai, Daisuke Urabe, Tetsuaki Tanaka,* Stereodivergent and reiterative synthesis of bis-tetrahydrofuran ring cores in annonaceous acetogenins, Chem. Eur. J., 10, 672–680 (2004).

  56. Naoto Kojima, Naoyoshi Maezaki, Hiroaki Tominaga, Mikito Asai, Minori Yanai, Tetsuaki Tanaka,* Systematic construction of a monotetrahydrofuran-ring library in annonaceous acetogenins by asymmetric alkynylation and stereodivergent tetrahydrofuran-ring formation, Chem. Eur.J., 9, 4980–4990 (2003).

  57. Naoyoshi Maezaki, Naoto Kojima,Hiroaki Tominaga, Minori Yanai, Tetsuaki Tanaka,* Systematic synthesis of bis-THF ring cores in annonaceous acetogenins, Org. Lett., 5,1411–1414 (2003).

  58. Naoyoshi Maezaki, Naoto Kojima, Atsunobu Sakamoto, Hiroaki Tominaga, Chuzo Iwata, Tetsuaki Tanaka,* Morito Monden,* Bazarragchaa Damdinsuren, Shoji Nakamori, Total synthesis of the antitumor scetogenin mosin B: Desymmetrization approach to the stereodivergent synthesis of threo/trans/erythro-Type acetogenins (selected as Cover Art), Chem. Eur. J., 9, 389–399 (2003).

  59. Naoyoshi Maezaki, Naoto Kojima, Mikito Asai, Hiroaki Tominaga, Tetsuaki Tanaka,* Highly stereoselective and stereodivergent synthesis of four types of THF cores in acetogenins Using C4-chiral building block, Org. Lett., 4, 2977–2980 (2002).

  60. Naoyoshi Maezaki, Naoto Kojima, Atsunobu Sakamoto, Chuzo Iwata, Tetsuaki Tanaka,* First total synthesis of mosin B, Org. Lett., 3, 429–432 (2001).

  61. Naoyoshi Maezaki, Atsunobu Sakamoto, Noboru Nagahashi, Motohiro Soejima, Ying-Xia Li, Tsuneaki Imamura, Naoto Kojima, Hirohumi Ohishi, Ken-ichi Sakaguchi, Chuzo Iwata, Tetsuaki Tanaka,* C2-Symmetric bis-sulfoxide: a novel chiral auxiliary for asymmetric desymmetrization of cyclic meso-1,2-diols, J. Org. Chem., 65, 3284–3291 (2000).

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Review

  1. Naoto Kojima,* Tetsuaki Tanaka,* Medicinal chemistry of annonaceous acetogenins: Design, synthesis, and biological evaluation of novel analogues (Invited review), Molecules, 14, 3621–3661 (2009).

  2. Naoyoshi Maezaki, Naoto Kojima, Tetsuaki Tanaka,* Systematic synthesis of diastereomeric THF-ring cores and total synthesis of antitumor annonaceous acetogenins (Review), Synlett, 993–1003 (2006).

  3. 小島直人,* 抗腫瘍活性バンレイシ科アセトゲニン類の系統的不斉合成法の開発 (Invited review), YAKUGAKU ZASSHI, 124,673–681 (2004).

Critique

  1. 小島直人,* パクリタキセルを越える抗がん剤を目指して：新規微小管安定化剤の開発 (トピックス), ファルマシア, 45, 575–576(2009).

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