Kyoto Pharmaceutical University, Division of Medicinal Chemical Sciences, Department of Pharmaceutical Manufacturing Chemistry

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Hiroki Iwasaki

Educational background

在学期間 学校名
2002年3月15日 神戸薬科大学薬学部薬学科卒業 学士(薬学)取得
2002年4月1日 大阪大学大学院 薬学研究科 分子薬科学専攻 博士前期課程 入学
2004年3月25日 大阪大学大学院 薬学研究科 分子薬科学専攻 博士前期課程 修了　修士(薬学)取得
2004年4月1日 大阪大学大学院 薬学研究科 分子薬科学専攻 博士後期課程 入学
2004年8月15日 University of Oklahoma Chemistry and Biochemistry 留学
2005年8月15日 大阪大学大学院 薬学研究科 分子薬科学専攻 博士後期課程 復学
2008年3月25日 大阪大学大学院 薬学研究科 分子薬科学専攻 博士後期課程 修了　博士(薬学)取得

Work history

期間 勤務先　及び　職名
2008年4月1日 岩城製薬株式会社　入社
2010年3月31日 岩城製薬株式会社　退社
2010年4月1日 京都薬科大学　助手
2011年4月1日 京都薬科大学　助教
2006年4月 日本薬学会　所属
2016年8月 有機合成化学協会

Original article

  1. Kaito Ohta, Tetsuya Fushimi, Mutsumi Okamura, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety, RSC Advances,12, 15728–15739 (2022).
  2. Kaito Ohta, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Structure-activity relationships of thiophene carboxamide annonaceous acetogenin analogs: Shortening the alkyl chain in the tail part significantly affects their growth inhibitory activity against human cancer cell lines, Chem. Pharm. Bull., 69, 1029–1033 (2021).
  3. Aya Niki, Minoru Ozeki,* Akiko Kuse, Shiho Nakagawa, Syui Aoki, Takashi Shigeta, Tetsuya Kajimoto, Hiroki Iwasaki, Naoto Kojima, Kenji Arimitsu, Shinzo Hosoi, Manabu Node, Masayuki Yamashita, Ikuo Kawasaki,* Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine, Chem. Pharm. Bull., 69, 926–930 (2021).
  4. Kenji Arimitsu, * Hiroki Iwasaki, Hiroyuki Kimura, Hiroyuki Yasui, Strong Binding Affinity of d-Allulose and Allulosides to Boronic Acids and Structural Characterization of Their Sugar-boronate Complexes, Chem. Lett. 50, 1470-1474, (2021).
  5. Yun-Han Hsieh, Hiroki Iwasaki, Yumina Iwai, Yuki Tanabe, Rinako Taketomo, Suzuna Yamanishi, Yuichiro Tanaka, Naoto Kojima, Masayuki Yamashita,* Reaction of 3-Oxa-2-oxobicyclo[4.2.0]oct-4-ene-1-carboxylate with Dimethylsulfoxonium Methylide, Chem. Pharm. Bull., 69, 391–399 (2021).
  6. Yun-Han Hsieh, Hiroki Iwasaki, Yumina Iwai, Miki Adachi, Kanako Kitai, Eri Kuribayashi, Yuri Hirata, Suzuna Sakaguchi, Naoko Sakaguchi, Naoto Kojima, Masayuki Yamashita,* [2+2]Photocycloaddition of 5,6-Substituted 2-Oxo-2H-pyran-3-carboxylates with Alkenes, Heterocycles, 102, 254–273 (2021).
  7. Naoto Kojima,* Hiromi Hayashi, Hiroki Iwasaki, Masayuki Yamashita, Syntheses of C2′-Fluorinated Analogs of Solamin, Chem. Pharm. Bull., 68, 675–678 (2020).
  8. Toshio Fujiwara, Yuka Taniguchi, Yuri Kokuryu, Yuumi Baba, Daiki Kawano, Yuuki Kawakami, Shouta Suzuki, Yukiteru Katsumoto, Minoru Ozeki, Hiroki Iwasaki, Ichiro Takahashi, Naoto Kojima, Masayuki Yamashita,* Shinzo Hosoi,* Application of a novel chromophoric reagent, 2,2′-binaphthyl-3,3′-dicarbonyl cyanide, to the absolute configuration determination of chiral secondary alcohols, Tetrahedron Lett., 61, 151984 (2020).
  9. Takuya Matsumoto, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima,* Synthesis and cancer cell growth inhibition effects of acetogenin analogs bearing ethylene glycol units for enhancing the water solubility, Tetrahedron, 76, 131058 (2020).
  10. Toru Tanaka, Shoki Inoue, Takuya Miura, Yun-Han Hsieh, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* FACILE PEPARATION OF 2-OXO-2H-1-PYRAN-3-CARBOXYLATES WITH THE ELECTRON-WITHDRAWING GROUP AT THE 5-POSITION, Heterocycles, 100, 429–439 (2020).
  11. Minoru Ozeki,* Ayumi Hachino, Takashi Shigeta, Aya Niki, Natsuko Kobayashi, Hideki Mizutani, Akihiro Nakamura, Ayano Horie, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Masayuki Yamashita, Ikuo Kawasaki,* A facile and convenient synthesis of trisubstituted (E)-α,β-unsaturated esters by tandem acetylation-E1cB reaction, Chem. Pharm. Bull., 67, 71–74 (2019).
  12. Takuya Matsumoto, Naoto Kojima,* Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines, Tetrahedron, 73, 2359–2366 (2017).
  13. Minoru Ozeki,* Honoka Egawa, Toshiki Takano, Hideki Mizutani, Narumi Yasuda, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Novel and practical asymmetric synthesis of β2,3-amino esters using asymmetric Michael addition of chiral amine, Tetrahedron, 73, 2014–2021 (2017).
  14. Toru Tanaka, Masaki Nagahama, Navnath Dnyanoba Yadav, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* SKELETAL TRANSFORMATION OF 2a,8b-DIHYDROBENZO[b]CYCLOBUTE[d]PYRAN-3-ONES INTO DIHYDRODIBENZOFURANS, Heterocycles, 92, 1665–1673 (2016).
  15. Minoru Ozeki,* Noboru Hayama, Shintaro Fukutome, Honoka Egawa, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Construction of Seven Contiguous Chiral Centers by Two Methods: Quadruple Michael Addition vs Stepwise Double-Double Michael Addition Controlled by Adding Speed of Michael Acceptor, ChemistrySelect, 1, 2565–2569 (2016).
  16. Toru Tanaka, Masaki Nagahama, Navnath Dnyanoba Yadav, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Reaction of 2a,8b-dihydrobenzo[b]cyclobute[d]pyran-3-ones with dimethylsulfoxonium methylide, Chem. Pharm. Bull., 64, 1056–1061(2016).
  17. Toru Tanaka, Takuya Miura, Shoki Inoue, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Skeletal transformation of α-pyrones having electron-withdrawing groups at 3,5-positions into ring-fused dihydrofurans, Tetrahedron Lett., 56, 6327–6331 (2015).
  18. Minoru Ozeki,* Honoka Egawa, Akiko Kuse, Toshiki Takano, Narumi Yasuda, Hideki Mizutani, Sumire Izumiya, Daichi Nakashima, Kenji Arimitsu, Takuya Miura, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* Practical and highly stereoselective synthesis of trisubstituted (E)-α,β-unsaturated esters, Synthesis, 47, 3392–3402 (2015).
  19. Kenji Suzuki, Hiroki Iwasaki, Reika Domasu, Naho Hitotsuyanagi, Yuka Wakizaka, Mao Tominaga, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Construction of pyrrolophenanthridinone scaffolds mediated by samarium(II) diiodide and access to natural product synthesis, Tetrahedron, 71, 5513–5519 (2015).
  20. Kenji Suzuki, Hiroki Iwasaki, Fumihito Ichiyoshi, Mao Tominaga, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Synthesis of 3-ethenylindoles via intramolecular cyclization of aryl radical with allene generated by samarium(II) diiodide, Heterocycles, 91, 1244–1255 (2015).
  21. Shinzo Hosoi, Minoru Ozeki,* Masashi Nakano, Kenji Arimitsu, Tetsuya Kajimoto, Naoto Kojima, Hiroki Iwasaki, Takuya Miura, Hiroyuki Kimura, Manabu Node, Masayuki Yamashita,* Mechanistic aspects of asymmetric intramolecular Heck reaction involving dynamic kinetic resolution: flexible conformation of the cyclohexenylidene–benzene system, Tetrahedron, 71, 2317–2326 (2015).
  22. Naoto Kojima,* Yuki Suga, Takuya Matsumoto, Tetsuaki Tanaka, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines, Bioorg. Med. Chem., 23, 1276–1283 (2015).
  23. Naoto Kojima,* Tetsuya Fushimi, Takahiro Tatsukawa, Tetsuaki Tanaka, Mutsumi Okamura, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead, Eur. J. Med. Chem., 86, 684–689 (2014).
  24. Takuya Miura, Saki Fujioka, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Skeleton transformation of α-pyrone induced by 5-aryl substituent into ring-fused dihydrofuran, Tetrahedron Lett., 55, 1536–1539 (2014).
  25. Takuya Miura, Saki Fujioka, Naoto Takemura, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Synthesis of 6-subtituted 3-(alkoxycarbonyl)-5-aryl-α-pyrones, Synthesis, 46, 496–502 (2014).
  26. Hiroki Iwasaki, Kenji Suzuki, Mitsunari Yamane, Shohei Yoshida, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita,* Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide, Org. Biomol. Chem., 12, 6812–6815 (2014).
  27. Naoto Kojima,* Tetsuya Fushimi, Takahiro Tatsukawa, Takehiko Yoshimitsu, Tetsuaki Tanaka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita,* Structure–activity relationships of hybrid annonaceous acetogenins: powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines, Eur. J. Med. Chem., 63, 833–839 (2013).
  28. Minoru Ozeki,* Megumi Satake, Toshinori Toizume, Shintaro Fukutome, Kenji Arimitsu, Shinzo Hosoi, Tetsuya Kajimoto, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita,* First asymmetric total synthesis of (+)-taiwaniaquinol D and (-)-taiwaniaquinone D by using intramolecular Heck reaction, Tetrahedron, 69, 3841–3846 (2013).
  29. Naoto Kojima,* Masato Abe, Yuki Suga, Kazufumi Ohtsuki, Tetsuaki Tanaka, Hiroki Iwasaki, Masayuki Yamashita, Hideto Miyoshi,* Critical role of a methyl group on the γ-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I, Bioorg. Med. Chem. Lett., 23,1217–1219 (2013).
  30. Takuya Miura, Navnath Dnyanoba Yadav, Hiroki Iwasaki, Minoru Ozeki, Naoto Kojima, Masayuki Yamashita,* Novel skeleton transformation reaction of α-pyrone derivatives to spirobicyclo[3.1.0]hexane derivatives using dimethylsulfoxonium methylide, Org. Lett., 14, 6048–6051(2012).
  31. Toshio Fujiwara, Yuka Taniguchi, Yukiteru Katsumoto, Takeyuki Tanaka, Minoru Ozeki, Hiroki Iwasaki, Manabu Node, Masayuki Yamashita,* Shinzo Hosoi, Novel approach to determining the absolute configurations at the C3-positions of various types of sterols based on an induced circular dichroism, Steroids, 77, 1198-1204 (2012).
  32. Sayo Nomura, Kenji Arimitsu, Satoshi Yamaguchi, Yuya Kosuga, Yuko Kakimoto, Takanori Komai, Kazumasa Hasegawa, Akira Nakanishi, Tamami Miyoshi, Hiroki Iwasaki, Minoru Ozeki, Ikuo Kawasaki, Ai Kurume, Shunsaku Ohta, Masayuki Yamashita,* Synthesis of (+,-)-8-Deisopropyladunctin B, Chem. Pharm. Bull., 60, 94-103(2012).
  33. Kenji Arimitsu, Sayo Nomura, Hiroki Iwasaki, Minoru Ozeki, Masayuki Yamashita,* First total synthesis of (±)-adunctin B, Tetrahedron Lett., 52, 7046-7048 (2011).
  34. Hiroki Iwasaki, Nozomi Tsutsui, Toru Eguchi, Hiroaki Ohno, Masayuki Yamashita,* Tetsuaki Tanaka, A novel samarium(II)-mediated tandem spirocyclization onto an aromatic ring, Tetrahedron Lett., 52, 1770-1772 (2011).
  35. Masayuki Yamashita,* Junko Kitao, Naoko Kitamura, Nozomi Kumo, Ai Kurume, Kenji Arimitsu, Hiroki Iwasaki, Minoru Ozeki, The First Total Synteses of (+)-Hostmanin A and (+)-Methyllinderatin, Heterocycles, 83, 143-151 (2011).
  36. Hiroki Iwasaki, Toru Eguchi, Nozomi Tsutsui, Hiroaki Ohno, Tetsuaki Tanaka, Samarium(II)-Mediated Spirocyclization by Intramolecular Aryl Radical Addition onto an Aromatic Ring, J. Org. Chem., 73, 7145-7152 (2008).
  37. Hiroaki Ohno, Hiroki Iwasaki, Toru Eguchi, Tetsuaki Tanaka,* The first samarium(II)-mediated aryl radical cyclisation onto an aromatic ring, Chem. Commun., 19, 2228-2229 (2004).
  38. Hiroaki Ohno, Mitsuaki Okumura, Shin-ichiro Maeda, Hiroki Iwasaki, Ryutaro Wakayama, Tetsuaki Tanaka,* Samarium(II)-Promoted Radical Spirocyclization onto an Aromatic Ring, J. Org. Chem., 68, 7722-7732 (2003).
  39. Hiroaki Ohno, Ryutaro Wakayama, Shin-ichiro Maeda, Hiroki Iwasaki, Mitsuaki Okumura, Chuzo Iwata, Hidenori Mikamiyama, Tetsuaki Tanaka,* Radical Cyclization by Ipso Substitution of the Methoxy Group: Considerable Effect of HMPA on Samarium-Mediated Cyclization, J. Org. Chem., 68, 5909-5916 (2003).
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