【論文】

1.         Miyuki Kobara, Nessa Naseratun,Hiroe Toba and Tetsuo Nakata. Preconditioning with short-term dietary restriction attenuates cardiac oxidative stress and hypertrophy induced by chronic pressure overload. Nutrients 13(3), 737; https://doi.org/10.3390/nu13030737 (2021).

2.         Naseratun Nessa, Miyuki Kobara, Hiroe Toba, Tetsuya Adachi, Toshiro Yamamoto, Narisato Kanamura, Giuseppe Pezzotti, Tetsuo Nakata. Febuxostat Attenuates the Progression of Periodontitis in Rats. Pharmacology. https://doi.org/10.1159/000513034 (2021).

3.         Nessa Naseratun, Miyuki Kobara , Yusuke Watanabe, Hiroe Toba, Tetsuo Nakata. Comparison of effects of L/N-type and L-type calcium channel blockers on post-infarct cardiac remodelling in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 00:1–9. DOI: 10.1111/1440-1681.13329 (2020).

4.         Yusuke Watanabe, Kaori Ohata, Ayaka Fukanoki, Naoto Fujimoto, Maruri Matsumoto, Naseratun Nessa, Hiroe Toba, Miyuki Kobara, Tetsuo Nakata. Antihypertensive and renoprotective effects of dietary flaxseed and its mechanism of action in deoxycorticosterone acetate-salt hypertensive rats. Pharmacology. 105, 54-62 (2020).

5.         Takashi Koizumi, Katsutoshi Taguchi, Ikuko Mizuta, Hiroe Toba, Makoto Ohigashi, Okihiro Onishi, Kazuya Ikoma, Seiji Miyata, Tetsuo Nakata, Masaki Tanaka, Sebastien Foulquier, Harry W. M. Steinbusch, Toshiki Mizuno. Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model. J. Neuroinflammation. 16:79. doi:10.1186/s12974-019-1467-7 (2019).

6.         Hiroe Toba, Merry L. Lindsey. Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly. PharmacologyTherapeutics. 193, 99-120 (2019).

7.         Cesar A. Meschiari, Mira Jung, Rugmani Padmanabhan Iyer, Andriy Yabluchanskiy, Hiroe Toba, Michael R. Garrett, Merry L. Lindsey. Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction. Am. J. Physiol. Heart. Circ. Physiol. 314, H224-H235 (2018).

8.         Makoto Ohigashi, Miyuki Kobara, Tamotsu Takahashi, Hiroe Toba, Takehiko Wada, and Tetsuo Nakata: Pitavastatin suppresses hyperglycaemia-induced podocyte injury via bone morphogenetic protein-7 preservation. Clin. Exp. Pharmacol.Physiol., 44, 378-385 (2017).

9.         Hiroe Toba, Presley L. Cannon, Andriy Yabluchanskiy, Rugmani Padmanabhan Iyer, Jeanine D’Armiento, and Merry L. Lindsey: Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis. Am. J. Physiol. Heart. Circ. Physiol., 312, H375-H383 (2017).

10.     Makoto Ohigashi, Nobuyoshi Imai, Hiroe Toba, Miyuki Kobara, and Tetsuo Nakata: Pitavastatin exhibits protective effects on podocytes accompanied by BMP-7 up-regulation and rho suppression. Pharmacol., 97, 265-276 (2016).

11.     Hiroe Toba, Lisandra E. de Castro Brás, Catalin F. Baicu, Michael R. Zile, Merry L. Lindsey, and Amy D. Bradshaw: Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am. J. Physiol. Endocrinol. Metab., 310, E1027-E1035 (2016).

12.     Miyuki Kobara, Akiko Furumori-Yukiya, Miho Kitamura, Mihoko Matsumura, Makoto Ohigashi, Hiroe Toba, and Tetsuo Nakata: Short-term caloric restriction suppresses cardiac oxidative stress and hypertrophy caused by chronic puressure overload . J. Card. Fail., 21, 656-666 (2015).

13.     Hiroe Toba, Lisandra E. de Castro Brás, Catalin F. Baicu, Michael R. Zile, Merry L. Lindsey, and Amy D. Bradshaw: Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am. J. Physiol. Cell. Physiol., 308, C972-982 (2015).

14.     Yonggang Ma, Rugmani Padmanabhan Iyer, Lisandra E. de Castro Brás, Hiroe Toba, Andriy Yabluchanskiy, Kristine Y. Deleon-Pennell, Michael E. Hall, Richard A. Lange, and Merry L. Lindsey: Cross talk between inflammation and extracellular matrix following myocardial infarction. Inflammation in Heart Failure, pp67-79, Academic Press (2015).

15.     Lisandra E. de Castro Brás, Hiroe Toba, Catalin F. Baicu, Michael R. Zile, Susan T. Weintraub, Merry L. Lindsey, and Amy D. Bradshaw: Age and SPARC change the extracellular matrix composition of the left ventricle. Biomed. Res. Int., 2014, Article ID 810562, 7 pages (2014).

16.     Andriy Yabluchanskiy, Yonggang Ma, Ying Ann Chiao, Elizabeth F. Lopez, Andrew P. Voorhees, Hiroe Toba, Michael E. Hall, Hai-Chao Han, Merry L. Lindsey, and Yu-Fang Jin: Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. Am. J. Physiol. Heart. Circ. Physiol., 306, H1398-H1407 (2014).

17.     Andriy Yabluchanskiy, Yonggang Ma, Ying Ann Chiao, Elizabeth F. Lopez, Andrew P. Voorhees, Hiroe Toba, Michael E. Hall, Hai-Chao Han, Merry L. Lindsey, and Yu-Fang Jin: Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. Am. J. Physiol. Heart. Circ. Physiol., 306, H1398-H1407 (2014).

18.     Yonggang Ma, Lisandra E. de Castro Brás, Hiroe Toba, Rugmani Padmanabhan Iyer, Michael E. Hall, Michael D. Winniford, Richard A. Lange, Suresh C. Tyagi, Merry L. Lindsey: Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. Pflugers. Arch-Eur. J. Physiol., 466, 1133-1127 (2014).

19.     Hiroe Toba, Dolores Cortez, Merry L. Lindsey, Robert J. Chilton: Applications of miRNA technology for atherosclerosis. Curr. Atheroscler. Rep., 16, 386 (2014).

20.     Wang J, Toba H, Morita Y, Nakashima K, Noda K, Tian W, Kobara M, Nakata T: Endothelial dysfunction, macrophage infiltration and NADPH oxidase-dependent superoxide production were attenuated by erythropoietin in streptozotocin-induced diabetic rat aorta Pharmacology, 91, 48-58 (2013).

21.     Hiroe Toba, Chisato Tojo, Jiahong Wang, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Telmisartan inhibits vascular dysfunction and inflammation via activation of peroxisome proliferator-activated receptor-γ in subtotal nephrectomized rat . Eur. J. Pharmacol., 685, 91-98 (2012).

22.     Kazuki Noda, Miyuki Kobara, Junichi Hamada, Yusuke Yoshifuji, Tatsuya Shiraishi, Takuya Tanaka, Jiahong Wang, Hiroe Toba, and Tetsuo Nakata: Additive amelioration of oxidative stress and cardiac function by combined mineralocorticoid and angiotensin receptor blockers in postinfarct failing hearts. J. Cardiovasc. Pharmacol., 60, 140-149 (2012).

23.     Hiroe Toba, Yushi Kojima, Jiahong Wang, Kazuki Noda, Wei Tian, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta. Eur. J. Pharmacol., 691, 190-197 (2012).

24.     Hiroe Toba, Mamiko Yoshida, Chisato Tojo, Arisa Nakano, Yuko Oshima, Yushi Kojima, Kazuki Noda, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: L/N-type calcium channel blocker cilnidipine ameliorates proteinuria and inhibits the renal renin-angiotensin-aldosterone system in deoxycorticosterone acetate-salt hypertensive rats. Hypertens. Res., 34, 521-529 (2011). 23.

25.     Hiroe Toba, Masayuki Morishita, Chisato Tojo, Arisa Nakano, Yuko Oshima, Yushi Kojima, Mamiko Yoshida, Kohei Nakashima, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: Recombinant human erythropoietin ameliorated endothelial dysfunction and macrophage infiltration by increasing nitric oxide in hypertensive 5/6 nephrectomized rat aorta. Eur. J. Pharmacol., 656, 81-87 (2011).

26.     Hiroe Toba, Ayako Nakamori, Yoshimi Tanaka, Ryosuke Yukiya, Keisuke Tatsuoka, Masako Narutaki, Masaaki Tokitaka, Hitoshi Hariu, Miyuki Kobara, and Tetsuo Nakata: Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., 37, 62-68 (2010).

27.     Miyuki Kobara, Kazuki Noda, Miho Kitamura, Akiharu Okamoto, Tatsuya Shiraishi, Hiroe Toba, Hiroaki Matsubara, and Tetsuo Nakata: Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice. Cardiovasc.Res., 87, 424-430 (2010).

28.     Hiroe Toba, Kohei Nakashima, Yuko Oshima, Yushi Kojima, Chisato Tojo, Arisa Nakano, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin prevents vascular inflammation and oxidative stress in subtotal nephrectomized rat aorta beyond haematopoiesis. Clin. Exp. Pharmacol. Physiol., 37, 1139-1146 (2010).

29.     Hiroe Toba, Takuya Mitani, Tamotsu Takahashi, Nobuyoshi Imai, Ryoko Serizawa, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: Inhibition of the renal renin-angiotensin system and renoprotection by pitavastatin in type1 diabetes. Clin. Exp. Pharmacol. Physiol., 37, 1064-1070 (2010).

30.     Shinsaku Matsunaga, Mitsuhiko Okigaki, Mitsuo Takeda, Akihiro Matsui, Shoken Honsho, Asako Katsume, Eigo Kishita, Che Jishan, Tatsuya Kurihara, Yasushi Adachi, Alka Mansukhani, Miyuki Kobara, Yoshiaki Matoba, Tetsuya Tatsumi, and Hiroaki Matsubara: Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction. J. Mol .Cell .Cardiol., 46, 663-673 (2009).

31.     Hiroe Toba, Naoki Sawai, Masayuki Morishita, Shoko Murata, Mamiko Yoshida, Kohei Nakashima, Yosuke Morita, Miyuki Kobara, and Tetsuo Nakata: Chronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat. Eur. J. Pharmacol., 612, 106-114 (2009).

32.     Masateru Taira, Hiroe Toba, Masafumi Murakami, Ikumi Iga, Ryoko Serizawa, Shoko Murata, Miyuki Kobara, Tetsuo Nakata: Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Eur. J. Pharmacol., 589, 264-271 (2008 ).

33.     Hironori Hayashi, Miyuki Kobara, Masaki Abe, Nana Tanaka, Eri Gouda, Hiroe Toba, Hiroyuki Yamada, Tetsuya Tatsumi, Tetsuo Nakata, and Hiroaki Matsubara: Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens. Res., 31,363-375 (2008).

34.     Miyuki Kobara, Nahoko Sunagawa , Masaki Abe, Nana Tanaka, Hiroe Toba, Hironori Hayashi, Natsuya Keira, Tetsuya Tatsumi, Hiroaki Matsubara, and Tetsuo Nakata: Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment. J. Appl. Physiol., 104, 601-609 (2008).

35.     Noriko Kuwahara, Susumu Sasaki, Miyuki Kobara, Tetsuo Nakata, Tetsuya Tatsumi, Hidekazu Irie, Hiromichi Narumiya, Tsuguru Hatta, Kazuo Takeda, Hiroaki Matsubara, and Shinji Hushiki: HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis. Int. J. Cardiol., 123, 84-90 (2008).

36.     Mitsuo Takeda, Tetsuya Tatsumi, Shinsaku Matsunaga, Hironori Hayashi, Masaki Kimata, Shoken Honsho, Susumu Nishikawa, Akiko Mano, Jun Shiraishi, Hiroyuki Yamada, Tomosaburo Takahashi, Satoaki Matoba, Miyuki Kobara, and Hiroaki Matsubara: Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydoroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts. Hypertens.Res., 30, 427-437 (2007).

37.     Miyuki Kobara, Hiroe Toba, and Tetsuo Nakata: Somatic stem cells and cardiac regeneration. Pathophysiological and Biochemical Analyses of “Life-Style Related or Intractable Diseases”-Target Validation for Drug Therapy-, 97-107 (2006).

38.     Hiroe Toba, Shunsuke Miki, Takahiro Shimizu, Akiko Yoshimura, Riyako Inoue, Naoki Sawai, Rie Tsukamoto, Masahumi Murakami, Yosuke Morita, Yusuke Nakayama, Miyuki Kobara, and Tetsuo Nakata: The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta. Eur. J. Phamacol., 549, 124-132 (2006).

39.     Hiroe Toba, Eriko Gomyo, Shunsuke Miki, Takahiro Shimizu, Akiko Yoshimura, Riyako Inoue, Naoki Sawai, Rie Tsukamoto, Jun Asayama, Miyuki Kobara, and Tetsuo Nakata: Hyperinsulinaemia increases the gene expression of endothelial nitric oxide synthase and the phosphatidylinositol 3-kinase/Akt pathway in rat aorta. Clin. Exp. Pharmacol. Physiol., 33, 440-447 (2006).

40.     Hiroe Toba, Takahiro Shimizu, Shunsuke Miki, Riyako Inoue, Akiko Yoshimura, Rie Tsukamoto, Naoki Sawai, Miyuki Kobara, and Tetsuo Nakata: Calcium channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells. Hypertens. Res., 29, 105-116 (2006).

41.     Susumu Nishikawa, Tetsuya Tatsumi, Jun Shiraishi, Shinnsaku Matsunaga, Mitsuo Takeda, Akiko Mano, Miyuki Kobara, Natsuya Keira, Mitsuhiko Okinaga, Tomosaburo Takahashi, and Hiroaki Matsubara: Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis. J.Mol.Cell.Cardiol., 40, 510-519 (2006).

42.     Koji Ikeda, Ramendra K. Kundu, Shoko Ikeda, Miyuki Kobara, Hiroaki Matsubara, and Thomas Quertermous: Glia maturation factor-γ is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Circ. Res., 99, 424-433 (2006).
Jiro Moriguchi, Hiroshi Itoh, Sanae Harada, Kazuo Takeda, Tsuguru hatta, Tetsuo Nakata, Susumu Sasaki: Low Frequency Regular Exercise Improves Flow-Mediated Dilatation of Subjects with Mild Hypertension. Hypertens. Res. 28, 315-321 (2005).

43.     Hiroe Toba, Yoshitsugu Nakagawa, Shunsuke Miki, Takahiro Shimizu, Akiko Yoshimura, Riyako Inoue, Jun Asayama, Miyuki Kobara, Tetsuo Nakata: Calcium Channel Blockades Exhibit Anti-Inflammatory and Antioxidative Effects by Augmentation of Endothelial Nitric Oxide Synthase and the Inhibition of Angiotensin Converting Enzyme in the NG-Nitro-L-Arginine Methyl Ester-Induced Hypertensive Rat Aorta: Vasoprotective Effects beyond the Blood Pressure-Lowering Effects of Amlodipine and Manidipine. Hypertens. Res. 28, 689-700 (2005).

44.     Akiharu Okamoto, Takuya Iwamoto, Yuichiro Ii, Tomoyuki Furuta, Yoshiyuki Kagawa, Tetsuo Nakata, Shigeki Kuzuhara, Masahiro Okuda: A Case of Successful Treatment of Churg-Strauss Syndrome-induced Neuropathic Pain with Valproic Acid. Jpn. J. Pharm. Health Care Sci. 31, 827-831 (2005).

45.     神林祐子、向山直樹、小西洋子、西田克次: 薬剤管理指導業務の有用性_薬 学的介入とその評価から_. 日病薬誌, 413, 295-301 (2005).草場哲郎、丹田修司、亀山久子、玉垣圭一、沖垣光 彦、八田 告、 弓場達也、須崎陽子、中田徹男、松原弘明、佐々木 享: 急性テオフィリン中毒に対し血液吸着と血液透析を行 い改善した1 例. 透折会誌, 38, 1649-1653 (2005).

46.     Tetsuya Tatsumi, Natsuya Keira, Kazuko Akashi, Miyuki Kobara, Satoaki Matoba, Jun Shiraishi, Satoshi Yamanaka, Akiko Mano, Mitsuo Takeda, Susumu Nishikawa, Jun Asayama , Henry Fliss, Masao Nakagawa: Nitric oxide-cGMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts. J. Appl. Physiol., 96, 853-860 (2004).

47.     Tetsuya Tatsumi, Kazuko Akashi, Natsuya Keira, Satoaki Matoba, Akiko Mano, Jun Shiraishi, Satoshi Yamanaka, Miyuki Kobara, Nobuhiro Hibino, Satoru Hosokawa, Jun Asayama, Shinji Fushiki, Henry Fliss, Masao Nakagawa, Horoaki Matsubara: Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts. J. Mol. Cell. Cardiol,. 37, 775-784 (2004).

48.     Akiko Mano, Tetsuya Tatsumi, Jun Shiraishi, Natsuya Keira, Tetsuya Nomura, Mitsuo Takeda, Susumu Nishikawa, Satoshi Yamanaka, Satoaki Matoba, Miyuki Kobara, Hideo Tanaka, Takeshi Shirayama, Tetsuo Takamatsu, Yoshihisa Nozawa, Hiroaki Matsubara: Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways. Circulation, 110, 317-323 (2004).

49.     Akiko Mano, Tetsuya Tatsumi, Jun Shiraishi, Tetsuya Nomura, Mitsuo Takeda, Susumu Nishikawa, Satoshi Yamanaka, Natsuya Keira, Miyuki Kobara, Takeshi Shirayama, Hiroaki Matsubara: Identification of plasma membrane receptor for aldosterone-induced apoptosis via calcineurin-dependent nongenomic signaling in cardiac myocytes. Circulation, 110 supple III, 5-6 (2004).

50.     Teruaki Yamamoto, Kazuo Takeda, Sanae Harada, Tetsuo Nakata, Akihiro Azuma, Susumu Sasaki, Masao Nakagawa. HMG-CoA reductase inhibitor enhances inducible nitric oxide synthase expression in rat vascular smooth muscle cells; involvement of the Rho/Rho kinase pathway. Atherosclerosis, 166(2), 213-222. (2003).

51.     Satoshi Yamanaka, Tetsuya Tatsumi, Jun Shiraishi, Akiko Mano, Natsuya Keira, Satoaki Matoba, Jun Asayama, Sjinji Fushiki, Henry Fliss, Masao Nakagawa. Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes. J Am Coll Cardiol, 41, 870-878. (2003).

52.     Natsuya Keira, Tetsuya Tatsumi,, Satoaki Matoba, Jun Shiraishi, Satoshi Yamanaka, Kazuko Akashi, Miyuki Kobara, Jun Asayama, Shinji Fushiki, Henry Fliss, and Masao Nakagawa : Lethal effect of cytokine-induced nitric oxide and peroxynitrite on cultured rat cardiac myocytes. .J Mol Cell Cardiol., 34, 583-596 (2002).

53.     Sususmu Sasaki, Masao Nakagawa, Tetsuo Nakata, Akihiro Azuma, Shohei Sawada, Kazuo Takeda, and Jun Asayama : Effects of pravastatin on exercise electrocardiography test performance and cardiovascular mortality and morbidity in patients with hypercholesterolemia ― lipid intervention study in Kyoto -. Circ J, 66, 47-52 (2002).

54.     Tsuguru Hatta, Tetsuo Nakata, Sanae Harada, Masahiro Kiyama, Jiro Moriguchi, Satoshi Morimoto, Hiroshi Itoh, Susumu Sasaki, Kazuo Takeda, and Masao Nakagawa: Lowering of blood pressure improves endothelial dysfunction in hypertensive rats. Hypertens Res, 25, 455-460. (2002).

55.     Tetsuyoshi Kawa, Kazuo Takeda, Sanae Harada, Tsuguru Hatta, Jiro Moriguchi, Shigeyuki Miki, Satoshi Morimoto, Hiroshi Itoh, Tetsuo Nakata, Susumu Sasaki, ,and Masao Nakagawa: Hypothalamic nitric oxide attenuates the pressor responses elicited by acute environmental stress in awake rats. Life Sci, 71, 1429-1438. (2002).

56.     Sanae Harada, Tetsuo Nakata, Atsuhiko Oguni, Hidenori Kido, Tsuguru Hatta, Ryuichi Fukuyama, Shinji Fushiki, Susumu Sasaki, and Kazuo Takeda: Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure. Hypertens Res, 25, 779-786 (2002).
Ryuichi Fukuyama, Akihiko Nakayama, Taizen Nakase, Hiroe Toba, Teruo Mukainaka, Hirofumi Sakaguchi, Takuya Saiwaki, Hiromu, Sakurai, Mikio Wada, and Shinji Fushiki: A newly established neuronal p-0 cell line highly susceptible to oxidative stress accumulates iron and other metals. J Biol Chem, 277, 41455-41462 (2002).

57.     H Toba, R Fukuyama, M Sasaki, K Shiga, S Ishibashi, S Fushiki: A Japanese prtient with cerebrotendious xanthomatosis has defferent mutations within ywo functional domains of CYP27. Clin Genet, 61, 77-78 (2002).亀山久子、檜垣 正、吉栖正巳、竹田光男、山下 眞、藤原典子、 河野秀彦、河野能士、高橋良一、多田勇介、中田徹 男、澤田昌平、中川雅夫、平井栄美、榎 泰之、土橋康成:胃生検にて巨大胃 粘膜下血腫を形成した全身性アミロイドーシスの1 例、消化器内視鏡 14(2), (2002).

58.     Jun Shiraishi, Tetsuya Tatsumi, Natsuya Keira, Kazuko Akashi, Akiko Mano, Satoshi Yamanaka, Satoaki Matoba, Jun Asayama, Takeshi Yaoi, Shinji Fushiki, Henry Fliss, and Masao Nakagawa : Important role of energy-dependent mitochondorial pathway in cultured rat cardiac myocyte apoptosis. Am.J. Physiol. Heart Circ. Physiol.., 281, H16373-H1647 (2001).

59.     Tetsuo Nakata, Kazuo Takeda, Sanae Harada, Atsuhiko Oguni, Tsuguru Hatta, Tetsuyoshi Kawa, Hiroshi Itoh, Sususmu Sasaki, and Masao Nakagawa: Role of central nervous system
in the developmwnt of hypertension produced by chronic nitric oxide blockade in rats. Hypertens. Res., 24, 39-45 (2001).

60.     Tetsuya Tatsumi, Satoaki Matoba, Akira Kawahara, Natsuya Keira, Jun Shiraichi, Kazuko Akashi, Miyuki Kobara, Tetsuya Tanaka, Maki Katamura, Chiaki Nakagawa, Bon Ohta, Takeshi Shirayama, Kazuo Takeda, Jun Asayama, Henry Fliss, and Masao Nakagawa : Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes. J.A.C.C., 35, 1338-1346 (2000).

61.     Satoshi Morimoto, Susumu Sasaki, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Masao Nakagawa. Loperamide therapy in a patient with diarrhea and resistant hypertension. Am J Hypertens 13, 431-432 (2000).

62.     Hiroshi Fujita, Kazuo Takeda, Shigeyuki Miki, Sanae Harada, Tsuguru Hatta, Atsushi Uchida, Tetsuo Nakata, Susumu Sasaki, and Masao Nakagawa : Effect of L-arginine on endothelium-dependent coronary vasodilatory reserve in spontaneously hypertensive rats. Curr Therap Res 61, 680-689 (2000).

63.     Satoshi Morimoto, Susumu Sasaki, Shigeyuki Miki, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Masao Nakagawa : Pressor response to pulsatile compression of the rostral ventrolateral medulla mediated by nitric oxide and c-fos expression. Br J Pharmacol 129, 859-864 (2000).

64.     Satoshi Morimoto, Susumu Sasaki, Shigeyuki Miki, Tetsuyoshi Kawa, Kazue Nakamura, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Masao Nakagawa, and Shinji Fushiki : Nitric oxide is an excitatory modulator in the rostral ventrolateral medulla in rats. Am J Hyperterns 13, 1125-1134 (2000).

65.     白石 淳、辰巳哲也、計良夏哉、山中 聡、明石加 都子、的場聖 明、小原 幸、朝山 純: Staurosporineによる心筋細 胞apoptosisの誘導-細 胞内ATPレベルに基づく細胞死決定機構-心 筋の構造と代謝-19992223-292000.

66.     Satoaki Matoba, Tetsuya Tatsumi, Natsuya Keira, Akira Kawahara, Kazuko Akashi, Miyuki Kobara, Jun Asayama, and Masao Nakagawa : Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia / reoxygenation injury in cultured rat cardiac myocytes. Circulation. 99, 817-22 (1999).

67.     Satoshi Morimoto, Susumu Sasaki, Jiro Moriguchi, Shigeyuki Miki, Tetsuyoshi Kawa, Kazue Nakamura, Tatsuya Ichida, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Nakagawa: Pressor response to compression of ventrolateral meddula mediated by glutamate receptors. Hypertension 33, 1207-1213, (1999).

68.     Kazue Nakamura, Susumu Sasaki, Jiro Moriguchi , Satoshi Morimoto, Shigeyuki Miki , Tetsuyoshi Kawa , Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Masao Nakagawa: Central effect of endothelin and its antagonists on sympathetic and cardiovascular regulation in SHR-SP. J. Cardiovasc. Pharm. 33, 876-882, (1999).

69.     Satoshi Morimoto, Susumu Sasaki, Masahiro Kiyama, Tsuguru Hatta, Jiro Moriguchi, S Miki, Kazue Nakamura, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda and Masao Nakagawa : Sustained-release diltiazem overdose. J. Human Hypertens., 13, 643-644 (1999).

70.     万井弘基、武田和夫、木山昌洋、森本 聡、中田徹 男、佐々木 享、中川雅夫:原発性アルドステロン症と糖尿病を 合併したネフローゼ症候群の1例、日本腎臓学会誌 41442-447(1999).

71.     Tetsuya Tatsumi, Satoaki Matoba, Miyuki Kobara, Natsuya Keira, Akira Kawahara, Kouki Turuyama, Tetsuya Tanaka, Maki Katamura, Chiaki Nakagawa, Bon Ohta, Yasuhiro Yamahara, Jun Asayama, and Masao Nakagawa: Energy metabolism after ischemic preconditioning in streptozotocin-induced diabetic rat hearts. J. Am. Coll. Cardiol. 31, 707-15 (1998).

72.     Tetsuo Nakata, Kazuo Takeda, Tsuguru Hatta, Masahiro Kiyama, Jiro Moriguchi , Shigeyuki Miki, Tetsuyoshi Kawa, Satoshi Morimoto, Kazue Nakamura, Atsushi Uchida, Hiroshi Itoh, Susumu Sasaki, and Masao Nakagawa: Blockade of angiotensin II inhibits the elevation of blood pressure induced by insulin. J. Cardiovasc. Pharm. 31, 248-252 (1998).

73.     Satoshi Morimoto, Susumu Sasaki, Jiro Moriguchi, Shigeyuki Miki, Tetsuyoshi Kawa, Kazue Nakamura, Hiroshi Fujita, Hiroshi Itoh, Tetsuo Nakata, Kazuo Takeda, and Masao Nakagawa: Unique association of pheochromocytoma with contralateral nonfunctioning adrenal cortical adenoma. Am. J. Hypertens.11, 117-121 (1998).

74.     武田和夫、中田徹男、佐々木 享、水谷孝昭、赤松 春義、高田 治、伊東 宏、村上貞次、首藤達也、小林恭一郎、 田邊進一、竹迫俊行、中川雅夫:高血圧性心肥大に対する塩酸ベナゼプリル (チバセン錠)の効果、診療と新薬 35(9), 9-17 (1998).計良夏哉, 辰 巳哲也, 明石加都子, 小原 幸, 白石 淳, 河原 聡, 片 村真紀, 鶴山 幸喜, 田 中哲也, 中川千明, 太 田 凡, 朝山 純, 中 川雅夫:ラットエンドトキシンショックにおけるNO-cGMP pathwayの 筋収縮における役割. 心筋の構造と代謝. 301-307 (1998).

 

 

【学会発表】

1.         小原 幸, 鳥 羽裕恵, 中田徹男, 短 期間カロリー制限プレコンディショニングが圧負荷肥大心に与える影響, 30回日本循環薬理学会, 秋田, 2020.11.

2.         鳥羽裕恵, 貝 野洋太, 財前聡香, 西 川桃代, 山岡朗大, 小 原 幸, 中田徹男, スク ロース負荷インスリン抵抗性モデルラットにおけるエリスロポイエチンの効果の検討, 30回日本循環薬理学会, 秋田, 2020.11.

3.         小原 幸, 鳥 羽裕恵, 中田徹男, イマ チニブ誘導性心筋障害に対するオートファジーの役割, 94回日本薬理学会年会, 札幌, 2021.3.

4.         鳥羽裕恵, 貝 野洋太, 財前聡香, 西 川桃代, 山岡朗大, 小 原 幸, 中田徹男, イン スリン抵抗性モデルラットの耐糖能と腎・血管障害に対するエリスロポエチンの多面的効果の検討, 94回日本薬理学会年会, 札幌, 2021.3.

5.         Hiroe Toba, Miyuki Kobara, Tetsuo Nakata, SPARC increment is induced by renin-angiotensin system and induces collagen deposition via ADAMTS1 in DOCA-salt hypertensive rats, 85回日本循環器学会 学術集会, 横浜, 2021.3.

6.         渡部裕介, 鳥 羽裕恵, 小原 幸, 中 田徹男, 高脂肪食負荷SHRにおけるサルコぺニアの評価と当 帰の作用機序の検討, 49回 日本心脈管作動物質学会薬, 久留米, 2020.2.

7.         小原 幸, Naseratun Nessa, 渡部裕介, 鳥羽裕恵, 中田徹男, 心筋梗塞リモデリ ングに対するビソプロロールとアテ ノロールの効果, 93回 日本薬理学会年会, 横浜, 2020.3.

8.         Naseratun Nessa, 小原 幸, 渡部裕介, 鳥羽裕恵, 中田徹男, 歯周病に対するフェブキソスタットの保護効果の検討, 93回日本薬理学会年会, 横浜, 2020.3.

9.         小原 幸, Naseratun Nessa, 渡部裕介, 鳥羽裕恵, 中田徹男, 心筋細胞における N型Ca2+チャネルの発現およびその役割, 92回日本薬理学会年会, 大阪, 2019.3.

10.     鳥羽裕恵, 齋 藤貴巳, 川島稜生, 坂 上詩芳, 渡部裕介, Naseratun Nessa, 小原 幸, 中田徹男, 腎レニン・アンジオテンシン系活性化により誘導され るSPARCは腎障害を引き起こす, 92回日本薬理学会年会, 大阪, 2019.3.

11.     渡部裕介, 鳥 羽裕恵, 小原 幸, 中 田徹男, FlaxseedDOCA食塩負荷高血圧モデルラットにおける降 圧作用とその作用 機序の解析, 92回 日本薬理学会年会, 大阪, 2019.3.
7. Myuki Kobara, Yuusuke Watanabe, Naseratun Nessa, Hiroe Toba, Tetsuo Nakata, Analogue suppresses hyperglycemia-induced podocyte injury via akt phosphorylation,
83回日本循環器学会学術集会, 横浜, 2019.3.

12.     Miyuki Kobara, Naseratun Nessa, Yuusuke Watanabe, Hiroe Toba, Tetsuo Nakata, Glucagon-like peptide 1 analogue regulates mitochondrial fusion proteins via akt phosphorylation and attenuates hypoxia-reoxygenation injury in cultured myocytes, 83回日本循環器学会学術集会, 横 浜, 2019.3.

13.     H Toba, A Yamaoka, S Sakurai, Y Tanaka, A Miyamoto, N Nessa, Y Watanabe, M Kobara, T Nakata, Short term treatment of a low dose erythropoietin improves vascular function in a rat model of insulin resistance, ESC Congress Paris 2019, Paris, 2019.8.

14.     M Kobara, N Naseratun, Y Watanabe, H Toba, T Nakata, Nicorandil suppresses ischemia-induced cardiac interstitial norepinephrine enhancement and ventricular arrhythmia in hypertrophic hearts, ESC Congress Paris 2019, Paris, 2019.9.

15.     M Kobara, N Naseratun, Y Watanabe, H Toba, T Nakata, Rore of autophagy in imatinib-induced cardiotoxicity, ESC Congress Paris 2019, Paris, 2019.9

16.     小原 幸, ネッ サ ナセラトゥン, 渡部裕介, 鳥 羽裕恵, 中田徹男, 高 血糖足細胞障害に対するGLP-1受容体作動薬の保護効果とその機序の検討, 42回日本高血圧学会総会, 東京, 2019.10.

17.     鳥羽裕恵, 渡 部裕介, ナセラトゥン ネッサ, 小 原 幸, 中田徹男, 低 用量短期間のエリスロポイエチン投与はスクロース負 荷インスリン抵抗性モデルラットのインスリン抵抗性と血管障害を抑制する, 42回日本高血圧学会総会, 東京, 2019.10.

18.     渡部裕介, Naseratun Nessa, 鳥羽裕恵, 小原 幸, 中田徹男, 当帰の高脂肪食負 荷SHRにおける昇圧、ストレス耐性 に及ぼす影響の検討, 29回 日本循環薬理学会 第55回高血圧関連疾患モデル学会合同学会, 高松, 2019.11.

19.     Miyuki Kobara, Yuusuke Watanabe, Naseratun Nessa, Hiroe Toba, Tetsuo Nakata, Expresssion and roles of N-type Ca2+ channel in myocytes, 82回 日本循環器学会学術集会, 大阪, 2018.3.

20.     Miyuki Kobara, Yuusuke Watanabe, Naseratun Nessa, Hiroe Toba, Tetsuo Nakata, Glucagon-like peptide 1 analogue protects mitochondria and attenuates hypoxiareoxygenation injury in cultured myocytes, 82回日本循環器学会 学術集会, 大阪, 2018.3.

21.     Miyuki Kobara, Yuusuke Watanabe, Naseratun Nessa, Hiroe Toba, Tetsuo Nakata, Blockade of L/N-type calcium channels suppresses interstitial norepinephrine enhancement and remodeling after myocardial infarction in spontaneously hypertensive rats, 82回日本循環器学会 学術集会, 大阪, 2018.3.

22.     Hiroe Toba, Takami Saito, Ryoki Kawashima, Shiho Sakaue, Yusuke Watanabe, Naseratun Nessa, Miyuki Kobara, Tetsuo Nakata, Osteonectin and a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) induce fibrosis in deoxycorticosterone-salt hypertensive rat kidney, 28th European Meeting on Hypertension and Cardiovascular Protection, Barcelona, 2018.6.

23.     Hiroe Toba, Yusuke Watanabe, Naseratun Nessa, Takami Saito, Ryoki Kawashima, Shiho Sakaue, Miyuki Kobara, Tetsuo Nakata, ADAMTS1 induces renal inflammation and fibrosis via renin-angiotensin system, WCP2018-18th World Congress of Basic and Clinical Pharmacology, 京都, 2018.7.

24.     鳥羽裕恵, 渡 部裕介, Naseratun Nessa, 小原 幸, 中田徹男, DOCA食塩負荷高 血圧モデルラットの腎障害の機序にSPARCADAMTS1増 大が関与している, 41回 日本高血圧学会総会, 旭川, 2018.9.

25.     鳥羽裕恵, 渡 部裕介, 齋藤貴巳, 川 島稜生, 坂上詩芳, Naseratun Nessa, 小原 幸, 中田徹男, DOCA食塩負荷高血圧モデルラットの腎臓におけるSPARCの 発現と役割に関する検討, 28回 日本循環薬理学会, 東京, 2018.12.

26.     Naseratun Nessa,
小原 幸, 渡部裕介, 鳥 羽裕恵, 中田徹男, Blockade of L/N-type calcium channels suppresses cardiac norepinephrine level and remodeling after myocardial infarction in spontaneously hypertensive rats, 28回日本循環薬理学会, 東京, 2018.12.

27.     Miyuki Kobara, Yuusuke Watanabe, Naseratun Nessa, Hiroe Toba, and Tetsuo Nakata: Nicorandil suppresses ischemia-induced cardiac interstitial norepinephrine enhancement and ventricular arrhythmia in normal and hypertrophic hearts. 81回日本循環器学会学術集会 (金沢), 2017. 3.

28.     Hiroe Toba, Tomoka Suzuki, Akari Yoshikawa, Tomoki Noutomi, Yukari Mino, Shiho Ishikawa, Nanako Toda, Kouki Sugino, Naseratun Nessa, Yuusuke Watanabe, Miyuki Kobara, and Tetsuo Nakata: A disintegrin and metalloproteinase with thrombospondin type1motif (ADAMTS1) causes renal fibrosis in deoxycorticosterone acetate-salt hypertensive rats. 27th European Meeting on Hypertension and Cardiovascular Protection (Milan, Italy), 2017.6.

29.     鳥羽裕恵、渡部裕介、Naseratun Nessa、小原 幸、中田徹男: ADAMTS1DOCA食 塩負荷高血圧ラットの腎臓で線維化を促進させる. 40回日本高血圧学会総会 (愛媛), 2017. 10.

30.     小原 幸、渡部裕介、Naseratun Nessa、鳥羽裕恵、中田徹男: 高血圧性肥大心モデルラットの心筋梗塞後リモデリング に対するCa拮 抗薬の影響. 40回日本 高血圧学会総会 (愛媛), 2017. 10.

31.     渡部裕介、鳥羽裕恵、Naseratun Nessa、小原 幸、中田徹男: ADAMTS1DOCA食 塩負荷高血圧ラットの腎臓で線維化を促進させる. 27回日本循環薬理学会 (名古屋), 2017. 12.

32.     福山光理、大東 誠、鳥羽裕恵、小原 幸、中田徹男: STZ誘発1型糖尿病モデルラット における生体内微量金属元素の体 内分布について. 89回日本薬理学会年会 (横浜), 2016. 3.

33.     望月佳織、小原 幸、大東 誠、鳥羽裕恵、中田徹男: 高血圧ラット心筋梗塞後リモデリングに対するシルニジ ピンの効果. 89回日本 薬理学会年会 (横浜), 2016. 3.

34.     小林亮介、小原 幸、渡部裕介、Naseratun Nessa, 鳥羽裕恵、中田徹男: ニコランジルによる虚血性不整脈抑制効果とそ の機序に ついての検討. 130回 日本薬理学会近畿部会 (京都), 2016. 11.

35.     渡部裕介、大畑佳織、深野木文香、藤本直人、松本万瑠 里、Naseratun Nessa, 鳥羽裕恵、小原 幸、中田徹男: DOCA食塩負 荷高血圧モデルラットにおけるflaxseedの降圧効果および作用機序の検討. 26回日本循環薬理学会 (長野), 2016. 12.

36.     大東 誠、鳥羽裕恵、小原 幸、中田徹男: 高尿酸血症モデルラットにおける尿酸と臓器障害の関連 について. 88回日本薬 理学会年会 (名古屋), 2015. 3.

37.     Hiroe Toba, Lisandra de Castro Brás, Catalin Baicu, Michael Zile, Merry Lindsey, and Amy D. Bradshaw: SPARC facilitates inflammation in the aging heart and suppresses macrophage M2 polarization. Scientific Sessions & Annual Meeting at Experimental Biology 2015 (Boston, USA), 2015. 4.

38.     Miyuki Kobara, Toshihiro Amano, Makoto Ohigashi, Hiroe Toba, and Tetsuo Nakata: Nicorandil attenuates cardiac interstitial norepinephrine enhancement and ventricular arrhythmia during ischemia in normotensive and hypertensive hearts. The 79th Annual Scientific Meeting of the Japanese Circulation Society (大阪), 2015. 4.

39.     Miyuki Kobara, Makoto Ohigashi, Hiroe Toba, and Tetsuo Nakata: Glucagon-like peptide 1 analogue preserves mitochondrial fusion proteins and suppresses lethal myocyte injury after hypoxia-reoxygenation in cultured myocytes. The 79th Annual Scientific Meeting of the Japanese Circulation Society (大阪), 2015. 4

40.     三野由香利、大東 誠、鳥羽裕恵、小原 幸、中田徹男: 高尿酸血症が血管内皮機能に与える影響について. 38回日本高血圧学会総会 (愛媛), 2015. 10.

41.     Makoto Ohigashi, Miyuki Kobara, Tamotsu Takahashi, Hiroe Toba, Takehiko Wada, and Tetsuo Nakata: Pitavastatin suppresses hyperglycemia-induced podocyte injury via bone morphogenetic protein-7 preservation. The 78th Annual Scientific Meeting of the Japanese Circulation Society (
東京), 2014. 3.

42.     Miyuki Kobara, Makoto Ohigashi, Hiroe Toba, and Tetsuo Nakata: Glucagon-like peptide 1 analogue mediates mitochondrial quality control factors and attenuates hypoxia-reoxygenation injury in cultured myocytes. The 78th Annual Scientific Meeting of the Japanese Circulation Society (東京), 2014. 3.

43.     Hiroe Toba, L. E. de Castro Brás, S. T. Weintraub, Y-F. Jin, A. D. Bradshaw, and M. L. Lindsey: Age and SPARC dependent cardiac collagen changes. Experimental Biology 2014 (San Diego, USA), 2014. 4.

44.     Miyuki Kobara, Akiko Furumori, Makoto Ohigashi, Hiroe Toba, and Tetsuo Nakata: Short-term caloric restriction mediates cardiac redox state and improves diastolic function in pressure overload hypertrophy. ESC Congress 2014 (Barcelona, Spain), 2014. 8.

45.     瀬尾文菜、片山ちさ、加藤麻里、野口智也、大東 誠、 鳥羽裕恵、小原 幸、中田徹男: rebamipideは食塩負荷腎障害モデルラット において腎保護効果を示す. 64回 日本薬学会近畿支部総会・大会 (京都), 2014. 10.

46.     前村真里奈、小原 幸、石神拓郎、大東 誠、鳥羽裕 恵、中田徹男: 培養心筋細胞における虚血誘発性オートファジーに対する 腫瘍壊死因子αの 影響. 64回日本薬学会 近畿支部総会・大会 (京都), 2014. 10.

47.     中森 愛、黒川智美、長谷部晃、大東 誠、鳥羽裕恵、 小原 幸、中田徹男: 高尿酸血症モデルラットにおける臓器障害に関する検討. 64回日本薬学会近畿支部総 会・大会 (京都), 2014. 10.

48.     瀬尾文菜、加藤麻里、大東 誠、鳥羽裕恵、小原 幸、 中田徹男: rebamipideは食塩負荷腎障害モデルラットにおいて腎保護作用を示す. 37回日本高血圧学会総会 (横浜), 2014. 10.

49.     大鹿沙季、小原 幸、天野寿洋、大東 誠、中田徹男: 心筋虚血性不整脈に対するニコランジルの保護効果~心 筋カテコラミン遊離に対する影響~. 126回 日本薬理学会近畿部会 (和歌山), 2014. 10.

50.     Hiroe Toba, Lisandra E. de Castro Brás, Catalin F. Baicu, Michael R. Zile, Merry L. Lindsey, and Amy D. Bradshaw: SPARC deletion suppresses age-related cardiac inflammation. American Heart Association Scientific Sessions 2014 (Chicago, USA), 2014. 11.

51.     大東 誠、鳥羽裕恵、小原 幸、中田徹男: HMG-CoA還元酵素阻害薬pitavastatinpodocyte保護効果とBMP-7の 関与及びその機序について. 24回 日本循環薬理学会 (山形), 2014. 12.

52.     野田和揮、小原 幸、今山知久、齋藤萌子、辻美知瑠、 山田弘毅、王 佳虹、鳥羽裕恵、中田徹男: Eplerenoneconnexin43KCNE1/KCNQ1及 びSERCA2aを調節し心室性不整脈を抑制する. 85回日本薬理学会年会 (京都), 2012. 3.

53.     菅 愛華、小原 幸、吉川 亮、瀬部暁洋、松尾恭子、 野田和揮、王 佳虹、鳥羽裕恵、和田健彦、中田徹男: 高血糖によるポドサイト障害 に対するピタバスタチンのBMP7保持を介した保護作用. 85回日本薬理学会年会 (京都), 2012. 3.

54.     岡部真季、鳥羽裕恵、児島悠史、天野智仁、笠原葉月、 野村竜平、山岡奈津見、野田和揮、王 佳虹、小原 幸、中田徹男: エリスロポイエチンは一酸化窒素合成酵素阻害下において も多目的な血管保護効果を発揮する. 85回 日本薬理学会年会 (京都), 2012. 3.

55.     礒橋忠亮、鳥羽裕恵、東條千里、堀川竜弥、畑中千佳、 片田知花、王 佳虹、野田和揮、小原 幸、中田徹男: テルミサルタンはPPARγ刺激作用を介してCKDラッ トの血管障害を抑制する. 85回 日本薬理学会年会 (京都), 2012. 3.

56.     Miyuki Kobara, Shota Tsujimoto, Hiromi Nagai, Kazuki Noda, Jiahong Wang, Eri Iwai-Kanai, Hiroe Toba, and Tetsuo Nakata: Angiotensin_ induces autophagy in cardiac myocyte via reactive oxygen species production. The 76th Annual Scientific Meeting of the Japanese Circulation Society (
福岡), 2012. 3.

57.     Hiroe Toba, Yushi Kojima, Jiahong Wang, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin improved vascular dysfunction by inhibiting NADPH oxidase-derived superoxide production in L-NAME-treated rat aorta. The 76th Annual Scientific Meeting of the Japanese Circulation Society (福岡), 2012. 3.

58.      Kazuki Noda, Miyuki Kobara, Tatsuya Shiraishi, Koki Yamada, Jiahong Wang, Hiroe Toba, Satoaki Matoba, and Tetsuo Nakata: Eicosapentaenoic acid preserves mitochondrial fusion protein OPA-1 and oxidative phosphorylation in failing myocardium after myocardial infarction. The 76th Annual Scientific Meeting of the Japanese Circulation Society (福岡), 20112. 3.

59.     Jiahong Wang, Chisato Tojo, Hiroe Toba, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Telmisartan inhibits vascular dysfunction and inflammation via activation of peroxisome proliferator-activated receptor-γ in subtotal nephrectomized rat. The 76th Annual Scientific Meeting of the Japanese Circulation Society (福 岡), 2012. 3.

60.     Hiroe Toba, Chisato Tojo, Jiahong Wang, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Telmisartan ameliorates vascular dysfunction and inflammation via stimulation of peroxisome proliferator-activated receptor-gamma in subtotal nephrectomized rat. 22nd European Meeting on Hypertension and Cardiovascular Protection (London, UK), 2012. 4.

61.     Hiroe Toba, Yushi Kojima, Jiahong Wang, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta. 22nd European Meeting on Hypertension and Cardiovascular Protection (London, UK), 2012. 4.

62.     小原 幸、辻本昌太、田 維、野田和揮、王 佳虹、鳥 羽裕恵、中田徹男: Angiotensin_負荷による心筋オートファジー誘導とそ のメカニズムの検 討. 35回 日本高血圧学会総会 (名古屋), 2012. 9.

63.     鳥羽裕恵、王 佳虹、野田和揮、小原 幸、中田徹男: Telmisartanは高血圧合併CKDラットの大動脈における 炎症反応をAT1受容体ブロックとPPAR-γ活 性化を介して抑制する. 35回 日本高血圧学会総会 (名古屋), 2012. 9.

64.     野田和揮、小原 幸、王 佳虹、田 維、鳥羽裕恵、中 田徹男: Dahl食塩感受性モデルラットにおいて、アルドステロンは不 整脈原生イオンチャネル発現を調節し、心室性不整脈を誘発する. 35回日本高血圧学会総会 (名古屋), 2012. 9.

65.     王 佳虹、鳥羽裕恵、野田和揮、小原 幸、時高正明、 中田徹男: 鰹節抽出物は1型糖尿病モデルラットの腎障害を抑制する. 35回日本高血圧学会総会 (名古屋), 2012. 9.

66.     Hiroe Toba, Yushi Kojima, Kazuki Ishimizu, Yuko Iwata, Yusuke Taira, Jiahong Wang, Kazuki Noda, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin treatment inhibited NADPH oxidase-derived superoxide production and endothelial dysfunction in nitric oxide synthase inhibitor-treated rat aorta. 24th Scientific Meeting of the International Society of Hypertension (Sydney, Australia), 2012. 9.

67.     松本梨沙、小原 幸、重康英里子、武田 彩、千住忠 義、田 維、王 佳虹、野田和揮、鳥羽裕恵、中田徹男: 高血圧ラットにおける心筋 梗塞後リモデリングへのCa拮抗薬の効果. 122回日本薬理学会近畿部会 (大阪), 2012. 11.

68.     世古口拓也、鳥羽裕恵、久保美和、雪矢智穂子、永田孝 太郎、王 佳虹、高橋 有、今井延佳、小原 幸、中田徹男: ピタバスタチンによる 抗酸化作用を介した糖尿病性腎症抑 制効果と、糸球体BMP-7増加作用の検討. 84回日本薬理学会年会 (横浜), 2011. 3.

69.     小原雅史、鳥羽裕恵、和田洋一、山崎 藍、村田佳菜 子、呉 裕理、王 佳虹、折田 優、杉本洋一、田中良実、小原 幸、針生 仁、時高正明、中田徹男: 鰹節抽出物は脳内レニン・アンジオテンシン系 抑制により 降圧作用と腎障害抑制作用を発揮する _自然発症高血圧ラットを用いた検 討_. 84回日本薬理学 会年会 (横浜), 2011. 3.

70.     吉藤佑介、小原 幸、内田雄吾、辻本昌太、寒原智子、 小林優里、野田和揮、王 佳虹、金井恵理、鳥羽裕恵、中田徹男: エンドセリンによ る心筋細胞オートファジー誘導について の検討. 84回日本薬理学会年会 (横浜), 2011. 3.

71.     平良勇祐、鳥羽裕恵、西田紘子、酒井果林、麻那古信 之、王 佳虹、中野亜里紗、東條千里、森下真行、小原 幸、中田徹男: 低用量のエリスロポイエチンは造血を介さずに5/6腎摘高血圧ラットの大動脈障害を軽減する. 84回日本薬理学会年会 (横浜), 2011. 3.

72.     野田和揮、小原 幸、白石達也、金井寛人、前野卓也、 森近裕加、浪松美菜、西田愉可利、鳥羽裕恵、中田徹男: ダール食塩感受性モデル ラットにおけるコネキシ43の発 現変化及びエプレレノンの効果についての検討. 84回日本薬理学会年会 (横浜), 2011. 3.

73.     和田洋一、鳥羽裕恵、石水千樹、岩田由布子、平良勇 祐、市原由加里、竹谷拓也、王 佳虹、児島悠史、中島浩平、大嶌裕子、村田翔子、小原 幸、中田徹男: 部分腎摘ラットでは腎機能低下に相関した血管障害が起こ る. 84回日本薬理学会年会 (横浜), 2011. 3.

74.     Hiroe Toba, Shoko Murata, Yuko Oshima, Yushi Kojima, Kohei Nakashima, Kazuki Noda, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: Vascular dysfunction and remodeling occurred in accordance with renal impairment in nephrectomized rats. 21st European Meeting on Hypertension and Cardiovascular Prevention (Milan, Italy), 2011. 6.

75.     Miyuki Kobara, Kazuki Noda, Miho Kitamura, Shota Tsujimoto, Jiahong Wang, Hiroe Toba, Eri Iwai-Kanai, Satoaki Matoba, Hiroaki Matsubara, and Tetsuo Nakata: Role of autophagy in imatinib-induced cardiotoxicity. The 75th Annual Scientific Meeting of the Japanese Circulation Society (横浜), 2011. 8.

76.     Hiroe Toba, Kohei Nakashima, Yuko Oshima , Yushi Kojima, Chisato Tojo, Jiahong Wang, Miyuki Kobara, and Tetsuo Nakata: Low dose of erythropoietin improved endothelial dysfunction and inflammation in 5/6 nephrectomized rat aorta beyond hematopoiesis. The 75th Annual Scientific Meeting of the Japanese Circulation Society (横 浜), 2011. 8.

77.     Jiahong Wang, Yoshimi Tanaka, Yu Orita, Yoichi Sugimoto, Hiroe Toba, Keisuke Tatsuoka, Miyuki Kobara, Hitoshi Hariu, Masaaki Tokitaka, and Tetsuo Nakata: Dried bonito extract reduced blood pressure and renal injury and inhibited renal ACE expression in spontaneously hypertensive rats. The 75th Annual Scientific Meeting of the Japanese Circulation Society (横浜), 2011. 8.

78.     Jiahong Wang, Keisuke Tatsuoka, Yu Orita, Yoichi Sugimoto, Hiroe Toba, Miyuki Kobara, Hitoshi Hariu, Masaaki Tokitaka, and Tetsuo Nakata: Dried bonito extract inhibited proteinuria by the inhibition of renal ROS and ACE beyond blood pressure-lowering effect in DOCA-salt rats. The 75th Annual Scientific Meeting of the Japanese Circulation Society (横浜), 2011. 8.

79.     鳥羽裕恵、大嶌裕子、王 佳虹、村田翔子、野田和揮、 小原 幸、中田徹男: 部分腎摘ラットの血管障害はADMAによる血管ACE活性上昇を介 した酸化ストレスの上昇により発症する. 34回 日本高血圧学会総会 (宇都宮), 2011. 10

80.     鳥羽裕恵、児島悠史、王 佳虹、野田和揮、小原 幸、 中田徹男: ErythropoietinNOS阻害下においても造血を介さ ずに大動脈における内皮機能 低下と酸化ストレスを抑制する. 34回日本高血圧学会総会 (宇都宮), 2011. 10.
77.
王 佳虹、東條千里、鳥羽裕恵、野田和揮、小原 幸、 中田徹男: TelmisartanPPAR-γ活性化を介してCKDラットの大動脈における内皮機能障害と炎症を抑制する. 34回日本高血圧学会総会 (宇都宮), 2011. 10.

81.     吉川 亮、小原 幸、高橋 有、鳥羽裕恵、和田 健 彦、中田徹男: 糖尿病性腎障害に対するpitavastatinの抗酸化・BMP-7を介した保護効果. 34回日本高血圧学会総会 (宇都宮), 2011. 10.

82.     石原彰子、折田 優、王 佳虹、野田和揮、鳥羽裕恵、 小原 幸、中田徹男: インスリン抵抗性モデルラットにおける鰹節抽出物の腎・ 血管保護効果に関する検討. 120回 日本薬理学会近畿部会 (京都), 2011. 11.

83.     塚原大樹、杉本洋一、王 佳虹、野田和揮、鳥羽裕恵、 小原 幸、中田徹男: 食塩の血圧に依存しない、酸化ストレス産生上昇を介した 腎障害誘発機序についての検討. 120回日本薬理学会近畿部会 (京都), 2011. 11.

84.     大歳麻衣、小原 幸、辻本昌太、山本翔一朗、野田和 揮、王 佳虹、鳥羽裕恵、中田徹男: 培養心筋細胞を用いたAngiotensin_負荷にによるオートファジーとその誘導メカニズムの検討. 120回日本薬理学会近畿部会 (京都), 2011. 11.

85.     辻 美知瑠、小原 幸、白石達也、野田和揮、王 佳 虹、鳥羽裕恵、中田徹男: 心筋梗塞モデルラットにおけるエイコサペンタエン酸の効 果についての検討. 120回 日本薬理学会近畿部会 (京都), 2011. 11.

86.     Miyuki Kobara, Tatsuya Shiraishi, Kazuki Noda, Jiahong Wang, Hiroe Toba, and Tetsuo Nakata: Eicosapentaenoic acid preserves mitochondrial fusion protein OPA-1 and oxidative phosphorylation in failing myocardium after myocardial infarction. American Heart Association Scientific Sessions 2011 (Florida, USA), 2011.11.

87.     Miyuki Kobara, Kazuki Noda, Jiahong Wang, Hiroe Toba, Eri Kanai, Satoaki Matoba, Hiroaki Matsubara, and Tetsuo Nakata: Role of autophagy in imatinib-mediated cardiac toxicity. 28回国際心臓研究学会(ISHR)日本部会 (東京), 2011.12.

88.     Kazuki Noda, Miyuki Kobara, Jiahong Wang, Hiroe Toba, and Tetsuo Nakata: Eplerenone prevents connexin43 dispersion and mediates mRNA expression of SERCA2a and KCNE1/KCNQ1 ratio, leading to the suppression of ventricular arrhythmias. 28回国際心臓研究学会(ISHR)日 本部会 (東京), 2011.12.

89.     Miyuki Kobara, Yugo Uchida, Kenta Tanaka, Syota Tsujimoto, Hiroe Toba, Satoaki Matoba, Hiroaki Matsubara, and Tetsuo Nakata: Impaired lysosomal function mediates imatinib-induced autophagic myocytes death. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3.

90.     Hiroe Toba, Masayuki Morishita, Yuko Oshima, Yushi Kojima, Chisato Tojo, Arisa Nakano, Kohei Nakashima, Mamiko Yoshida, Miyuki Kobara, and Tetsuo Nakata: Low dose of erythropoietin inhibits endothelial dysfunction and inflammation in 5/6 nephrectomized rat aorta beyond hematopoiesis. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3.

91.     Syota Tsujimoto, Miyuki Kobara, Masaki Abe, Yugo Uchida, Kenta Tanaka, Hiroe Toba, and Tetsuo Nakata: Aldosterone nongenomically induces NADPH oxidase and mitochondria-derived reactive oxygen species production in myocytes. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3.

92.     Chisato Tojo, Hiroe Toba, Mamiko Yoshida, Arisa Nakano, Miyuki Kobara, and Tetsuo Nakata: Cilnidipine exhibited renoprotective effects and inhibited renal renin-angiotensin-aldosterone system in deoxycorticosterone-salt hypertensive rats. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京 都), 2010. 3.

93.     Kazuki Noda, Miyuki Kobara, Akiko Furumori, Miho Kitamura, Tatsuya Shiraishi, Hiroe Toba, and Tetsuo Nakata: Short-term caloric restriction mediates redox states and attenuates oxidative stress in pressure overload hypertrophy . The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3.

94.     Tamotsu Takahashi, Hiroe Toba, Ryoko Serizawa, Nobuyoshi Imai, Miyuki Kobara, and Tetsuo Nakata: Pitavastatin inhibited diabetic nephropathy via antioxidative properties and reduced renal renin-angiotensin-aldosterone system in rats. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3

95.     Yuko Oshima, Shoko Murata, Hiroe Toba, Yushi Kojima, Kohei Nakashima, Miyuki Kobara, and Tetsuo Nakata: Renal impairment by ablation caused endothelial dysfunction and inflammation in aorta and exaggerated cuff-placement induced hyperplasia in femoral artery. The 74th Annual Scientific Meeting of the Japanese Circulation Society (京都), 2010. 3.

96.     Hiroe Toba, Mamiko Yoshida, Chisato Tojo, Arisa Nakano, Miyuki Kobara, and Tetsuo Nakata: Cilnidipine inhibited renal injury and renin-angiotensin-aldosterone system in deoxycorticosterone-salt hypertensive rats. 20th European Meeting on Hypertension (Oslo, Norway), 2010. 6.

97.     Hiroe Toba, Masayuki Morishita, Yuko Oshima, Yushi Kojima, Chisato Tojo, Arisa Nakano, Kohei Nakashima, Mamiko Yoshida, Miyuki Kobara, and Tetsuo Nakata: Erythropoietin improved endothelial dysfunction and inflammation in 5/6 nephrectomized rat aorta beyond hematopoiesis. 20th European Meeting on Hypertension (Oslo, Norway), 2010. 6.

98.     小原 幸、野田和揮、王 佳虹、白石達也、辻本昌太、 鳥羽裕恵、中田徹男: 心不全における活性酸素種の役割および産生源. 生体機能と創薬シンポジウム2010京 都 (京都), 2010. 9.

99.     野田和揮、小原 幸、白石達也、鳥羽裕恵、中田徹男: Dahl食塩感受性モデルラットにおけるConnexin43の 発現変化及びEplerenoneの効果についての検討. 生体機能と創薬シンポジウム2010京 都 (京都), 2010. 9

100. 児 島悠史、森下真行、鳥羽裕恵、東條千里、大嶌裕子、 吉田満美子、中島浩平、野田和揮、王 佳虹、小原 幸、中田徹男: 5/6腎摘高血圧 ラットの胸部大動脈障害に対するerythropoietinの多面的な効果に関する 検討. 生体機能と創薬シンポジウム2010京 都 (京都), 2010. 9.

101. 中 野亜里紗、吉田満美子、鳥羽裕恵、東條千里、野田和 揮、王 佳虹、小原 幸、中田徹男: DOCA食塩負荷高血圧モデルラットを用いたL/N型カルシウムチャンネル拮抗薬cilnidipineに よる腎保護効果の検討. 生体機能と創薬シンポジウム2010京都 (京都), 2010. 9.

102. Hiroe Toba, Masayuki Morishita, Yuko Oshima, Yushi Kojima, Chisato Tojo, Arisa Nakano, Kohei Nakashima, Mamiko Yoshida, Miyuki Kobara, and Tetsuo Nakata: Low dose erythropoietin improved endothelial dysfunction and inflammation in hypertensive 5/6 nephrectomized rat aorta beyond hematopoiesis. The 23rd Scientific Meeting of the International Society of Hypertension (Vancouver, Canada), 2010. 9.

103. Hiroe Toba, Mamiko Yoshida, Chisato Tojo, Arisa Nakano, Miyuki Kobara, and Tetsuo Nakata: Cilnidipine inhibited proteinuria and renal renin-angiotensin-aldosterone system in deoxycorticosterone-
salt hypertensive rats. The 23rd Scientific Meeting of the International Society of Hypertension (Vancouver, Canada), 2010. 9.

104. Miyuki Kobara, Shota Tsujimoto, Kazuki Noda, Jiahong Wang, Hiroe Toba, Eri Kanai, Satoaki Matoba, Hiroaki Matsubara, and Tetsuo Nakata: Role of reactive oxygen species in imatinib-induced myocytes apoptosis.
14回日本心不全学会学術集会 (東京), 2010.10.

105. Kazuki Noda, Miyuki Kobara, Tatsuya Shiraishi, Jiahong Wang, Hiroe Toba, and Tetsuo Nakata: Eplerenone improves connexin43 localization and attenuates the inducibility of ventricular arrhythmias in dahl salt-sensitive rats. 14回日本心不全学会学術集会 (東京), 2010.10.

106. 小 原 幸、古森暁子、野田和揮、白石達也、鳥羽裕恵、 中田徹男: 圧負荷心肥大モデルマ ウスに対するカロリー制限の心肥大 及び酸化障害抑制効果. 33回 日本高血圧学会総会 (福岡), 2010. 10.

107. 鳥 羽裕恵、中島浩平、大嶌裕子、児島悠史、東條千里、 中野亜里紗、王 佳虹、小原 幸、中田徹男: 低用量のerythropoietinは造血を介さずに部分腎摘ラットの大動脈組織における内 皮機能低下とマクロファージの浸潤、NADPH oxidase活性を抑制する. 33回日本高血圧学会総会 (福岡), 2010. 10.

108. 高 橋 有、今井延佳、鳥羽裕恵、王 佳虹、小原 幸、 中田徹男: Pitavastatinstreptozotocin誘発糖尿病ラットの腎臓においてbone morphogenetic protein 7の発現増大を介しpodocyte保 護作用を示す. 33回日 本高血圧学会総会 (福岡), 2010. 10.

109. 折 田 優、立岡慶祐、杉本洋一、鳥羽裕恵、王 佳虹、 小原 幸、針生 仁、時高正明、中田徹男: 鰹 節抽出物は交感神経活性抑制による降圧作用とともに、 抗酸化作用と腎組織内ACE抑制を介し、DOCA-saltの 腎障害を改善する. 33回 日本高血圧学会総会 (福岡), 2010. 10.

110. 中 田徹男: 生活習慣病におけるレニンアンジオテンシン・アルドス テロン系と抗酸化作用(抗アルドステロン薬の腎・血管保護効果を中心に)シンポジウム「活性酸素種/酸化的ストレスの関わる多様 な病態とその薬物治療」. 82回 日本薬理学会年会 (横浜), 2009. 3.

111. Miyuki Kobara, Makoto Ohigashi, Shouta Tsujimoto, Yuugo Uchida, Kenta Tanaka, Hiroe Toba, and Tetsuo Nakata: Imatinib induces autophagy-mediated cell death in cardiac myocytes. The 73rd Annual Scientific Meeting of the Japanese Circulation Society (大阪), 2009. 3.

112. Miyuki Kobara, Junichi Hamada, Takuya Tanaka, Tatsuya Shiraishi, Miho Kitamura, Kazuki Noda, Akiko Furumori, Hiroe Toba, and Tetsuo Nakata: Additive suppression of mitochondria-and NADPH oxidase-derived ROS by combined aldosterone and angiotensin receptor blockers in post-infarct failing hearts. The 73rd Annual Scientific Meeting of the Japanese Circulation Society (大阪), 2009. 3.

113. Hiroe Toba, Mamiko Yoshida, Masayuki Morishita, Chisato Tojo, Yosuke Morita, Miyuki Kobara, and Tetsuo Nakata: Chronic administration of recombinant human erythropoietin exhibits anti-inflammatory and anti-oxidative effects in experimental diabetic rat aorta beyond hematopoiesis. The 73rd Annual Scientific Meeting of the Japanese Circulation Society (大 阪), 2009. 3.

114. Hiroe Toba, Nobuyoshi Imai, Ryouko Serizawa, Tamotsu Takahashi, Takuya Mitani, Miyuki Kobara, and Tetsuo Nakata: Pitavastatin inhibited diabetic nephropathy and decreased renal renin-angiotensin-aldosterone system in rats. 19th European Meeting on Hypertension (Milan, Italy), 2009. 6.

115. Hiroe Toba, Mamiko Yoshida, Kouhei Nakashima, Masayuki Morishita, Shouko Murata, Chisato Tojo, Yuko Ohshima, Yosuke Morita, Miyuki Kobara, and Tetsuo Nakata: Chronic treatment with erythropoietin inhibits oxidative stress and inflammatory reaction in diabetic rat aorta beyond hematopoiesis. 19th European Meeting on Hypertension (Milan, Italy), 2009. 6.

116. 立 岡慶祐、田中良実、折田 優、杉本洋一、針生 仁、 時高正明、鳥羽裕恵、小原 幸、中田徹男: 鰹節抽出物 の降圧機序に関する検討. 115回 日本薬理学会近畿部会 (金沢), 2009. 6.
114.

117. 田 中健太、小原 幸、田中那奈、辻本昌太、内田雄吾、 鳥羽裕恵、中田徹男: ラット培養心筋細胞に おけるaldosterone誘起ギャップ結合リモデリングについての検討. 115回日本薬理学会近畿部会 (金沢), 2009. 6.