居室：京都薬科大学創フロンティア研究棟1階F11共測室
Phone：075-595-4725；E-mail：hattori@mb.kyoto-phu.ac.jp

履歴

略歴
2001年03月　信州大学農学部応用生命科学科卒業(機能分子化学研究室; 真壁秀文先生)
2003年03月　信州大学大学院農学研究科機能性食料開発学専攻修了(機能分子化学研究室; 真壁秀文先生)
2004年03月　株式会社ハイテック退社
2005年03月　信州大学農学部研究生終了
2005年07月～2008年3月　信州大学SVBL (サテライトベンチャービジネスラボラトリー) DC研究員
2008年03月　信州大学大学院総合工学系研究科生物・食料科学専攻修了(後藤哲久先生、真壁秀文先生)
2008年05月　National Institutes of Health, Visiting Fellow (NCI/LCB; Dr. Ettore Appella)
2009年08月　京都府立医科大学大学院医学研究科助教 (化学教室; 赤路健一先生、現：鈴木孝禎先生)
2011年10月　京都薬科大学創薬科学系薬品化学分野助教（赤路健一先生）
2016年04月　京都薬科大学共同利用機器センター助教（赤路健一先生）
2017年07月　京都薬科大学共同利用機器センター講師（赤路健一先生、現：古田巧先生）
　　　　　　 現在に至る

所属学会
日本農芸化学会、有機合成化学協会、日本薬学会、日本ペプチド学会、日本癌学会

以下の内容は2019年4月1日現在のものになります。これ以降につきましてはPublicationsをご参照ください。
原著論文

1.
Kameda, R.; Sohma, T.; Kobayashi, K.; Uchiyama, R.; Nosaka, K.; Konno, H.; Akaji, K.; Hattori, Y. Convergent synthesis of trans-2,6-disubstituted piperidine alkaloid, (ー)-iso-6-spectaline by palladium-catalyzed cyclization, Chem. Pharm. Bull. 2019, 67, 253–257.
2.
Ohnishi, K.; Hattori, Y.; Kobayashi, K.; Akaji, K. Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor, Bioorg. Med. Chem. 2019, 27, 425-435.
3.
Miyazawa, Y.; Hattori, Y.; Makabe, H. Synthesis of (+)-altholactone, (+)-7-epi-altholactone, (ー)-etharvensin, and (+)-alumheptolide-A using Pd-catalyzed carbonylation, Tetrahedron Lett. 2018, 59, 4024–4027.
4.
Ichikawa, M.; Yamamoto, S.; Ishihara, C.; Nonobe, S.; Hattor, Y.; Umezawa, K.; Fujii, H.; Makabe, H. Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells, Tetrahedron 2018, 74, 3534-3542.
5.
Asai, M.; Takemoto, Y.; Deguchi, A.; Hattori, Y.; Makabe, H. An asymmetric synthesis of (+)-monomorine I, Tetrahedron: Asymmetry, 2017, 28, 1582-1586.
6.
Takanashi, K.; Suda, M.; Matsumoto, K.; Ishihara, C.; Toda, K.; Kawaguchi, K.; Senga, S.; Kobayashi, N.; Ichikawa, M.; Katoh, M.; Hattori, Y.; Kawahara, S.; Umezawa, K.; Fujii, H.; Makabe, H. Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts, Scientific Reports, 2017, 7, 7791-7804.
7.
Asai, M.; Hattori, Y.; Makabe, H. Synthesis of isocoumarin compounds, 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one and fusariumin analog using palladium-catalyzed carbonylation trapping with O-Enolate, Heterocycles, 2017, 94, 1542-1553.
8.
Takemoto, Y.; Hattori, Y.; Makabe, H. Synthesis of (ー)-isosolenopsin using diastereoselective aminopalladation, Heterocycles, 2017, 94, 286-296.
9.
Mori, M.; Matsumoto, M.; Ishihara, C.; Kawaguchi, K.; Kawahara, S.; Hattori, Y.; Fujii, H.; Makabe, H. Synthesis of prodelphinidin trimer isolated from Cistus albidus and its antitumor activity against human prostate cancer cell lines, Heterocycles, 2016, 92, 1822-1831.
10.
Asai, M.; Hattori, Y.; Makabe, H. Synthesis of legioliulin, a fluorescent isocoumarin compound, isolated from Legionella dumoffii using cyclic acylpalladation and Heck reaction, Tetrahedron Lett. 2016, 57, 3942-3944.
11.
Teruya, K.; Hattori, Y.; Shimamoto, Y.; Kobayashi, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, E.; Akaji, K. Structural Basis for the Development of SARS 3CL Protease Inhibitors from a Peptide Mimic to an Aza-decaline Scaffold, Biopolymers, 2016, 106, 391-403.
12.
Ichikawa, M.; Takanashi, K.; Suda, M.; Hattori, Y.; Kawahara, S.; Fujii, H.; Makabe, H. Concise Synthesis of Cinnamtannin A2 from Dimeric Epicatechin Electrophile and Nucleophile Prepared by Zn(OTf)2-Mediated Self-Condensation, Synthesis, 2016, 48, 1525-1532.
13.
Kurogome, Y.; Hattori, Y.; Makabe, H. Synthesis of Decytospolide A, B and Their C-3 Epimers Using Stereoselective Oxypalladation, Synthesis, 2016, 48, 765-771.
14.
Hattori, Y.; Kobayashi, K.; Deguchi, A.; Nohara, Y.; Akiyama, T.; Teruya, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, A.; Akaji, K. Evaluation of Transition-state Mimics in a Superior BACE1 Cleavage Sequence as Peptide-mimetic BACE1 Inhibitors, Bioorg. Med. Chem. 2015, 23, 5626–5640.
15.
Katsuyama, M.; Furuta, M.; Kobayashi, K.; Teruya, K.; Makabe, H.; Akaji, K.; Hattori, Y. Divergent Synthesis of 2,6-Disubstituted Piperidine Alkaloid, (+)-Spectaline by Palladium-Catalyzed Cyclization, Heterocycles 2015, 91, 959-969.
16.
Ohnishi, K.; Sakurai, H.; Kobayashi, K.; Makabe, H.; Teruya, K.; Akaji, K.; Hattori, Y. Syntheses of a Pyrrolidine Analog of a Tetrahydrofuran Containing Acetogenin, cis-Solamin, Heterocycles 2015, 91, 573-582.
17.
Shimamoto, Y.; Hattori, Y.; Kobayashi, K.; Teruya, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, A.; Akaji, K. Fused-ring Structure of Decahydroisoquinolin as a Novel Scaffold for SARS 3CL Protease Inhibitors, Bioorg. Med. Chem. 2015, 23, 876–890.
18.
Toda, Y.; Takata, K.; Nakagawa, Y.; Kawakami, H.; Fujioka, S.; Kobayashi, K.; Hattori, Y.; Kitamura, Y.; Akaji, K.; Ashihara, E. Effective Internalization of U251-MG-secreted Exosomes into Cancer Cells and Characterization of Their Lipid Components, Biochem. Biophys. Res. Commun. 2015, 456, 768-773.
19.
Hikosawa, G.; Hattori, Y.; Makabe, H. Synthesis of Both Enantiomers of Akolactone B and (+)-Ancepsenolide, Tetrahedron: Asymmetry 2014, 25, 1367-1371.
20.
Suda, M.; Fujii, W.; Takanashi, K.; Hattori, Y.; Makabe, H.pSelective Synthesis of Epicatechin Dimers By Zinc(II) Triflate Mediated Self-condensation, Synthesis 2014, 46, 3351-3355.
21.
Tokuda, M.; Kurogome, Y.; Katoh, R.; Nohara, Y.; Hattori, Y.; Makabe, H. Synthesis of Four Diastereomers and Structural Revision of Tetradenolide, Tetrahedron Lett. 2014, 55, 4189-4192.
22.
Kurogome, Y.; Hattori, Y.; Makabe, H. Synthesis of (+)-Boronolide and (+)-Deacetylboronolide Using Pd-catalyzed Carbonylation and Lactonization, Tetrahedron Lett. 2014, 55, 2822-2824.
23.
Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K. Effect of Prime-site Sequence of Retro-inverso-modified HTLV-1 Protease Inhibitor, Bioorg. Med. Chem. 2014, 22, 2482-2488.
24.
Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjoh, A.; Kobayashi, K.; Hattori, Y.; Akaji, K. Synthesis and Evaluation of Curcumin Derivatives Toward an Inhibitor of Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Bioorg. Med. Chem. Lett. 2014, 24, 685-690.
25.
Fujii, W.; Toda, K.; Matsumoto, K.; Kawaguchi, K.; Kawahara, S.; Hattori, Y.; Fujii, H.; Makabe, H. Syntheses of Prodelphinidin B1, B2 and B4 and Their Antitumor Activities Against Human PC-3 Cancer Cell Lines, Tetrahedron Lett., 2013, 54, 7188-7192.
26.
Kurogome, Y.; Kogiso, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H. Total Synthesis of (+)-Azimine via Diastereoselective Aminopalladation, Tetrahedron, 2013, 69, 8349-8352.
27.
Suda, M.; Katoh, M.; Toda, K.; Matsumoto, K.; Kawaguchi, K.; Kawahara, S.; Hattori, Y.; Fujii, H.; Makabe, H. Syntheses of Procyanidin B2 and B3 Gallate Derivativesusing Equimolar Condensation Mediated by Yb(OTf)3 and Their Antitumor Activities, Bioorg. Med. Chem. Lett. 2013, 23, 4935-4939.
28.
Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K. Practical Synthesis of Peptide C-Terminal Aldehyde on a Solid Support, Tetrahedron Lett. 2013, 54, 4848-4850.
29.
Fujii, W.; Toda, K.; Kawaguchi, K.; Kawahara, S.; Katoh, M.; Hattori, Y.; Fujii, H.; Makabe, H. Syntheses of Prodelphinidin B3 and C2, and Their Antitumor Activities Through Cell Cycle Arrest and Caspase-3 Activation, Tetrahedron 2013, 69, 3543-3550.
30.
Hattori, Y.; Kinami, G.; Teruya, K.; Nosaka, K.; Kobayashi, K.; Akaji, K. A Practical Synthesis of a Hydroxylated Sesquiterpene Coumarin 10’R-Acetoxy-11’-hydroxyumbelliprenin by Regioselective Dihydroxylation, Heterocycles 2013, 87, 423-428.
31.
Ohizumi, Y.; Kato, M.; Hattori, Y.; Toda, K.; Kawaguchi, K.; Fujii, H.; Makabe, H. Synthesis of Procyanidin C2 and C1 Using Lewis Acid Mediated Equimolar Condensation, Heterocycles 2012, 85, 2241-2250.
32.
Nosaka, K.; Esaki, H.; Onozuka, M.; Konno, H.; Hattori, Y.; Akaji, K. Facilitated Recruitment of Pdc2p, a Yeast Transcriptional Activator, in Response to Thiamin Starvation, FEMS Microbiol. Lett. 2012, 330, 140-147.
33.
Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjoh, A. Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors, J. Med. Chem. 2011, 54, 7962-7973.
34.
Kakizawa, T.; Sanjoh, A.; Kobayashi, A.; Hattori, Y.; Teruya, K.; Akaji, K. Evaluation of Superior BACE1 Cleavage Sequences Containing Unnatural Amino Acids, Bioorg. Med. Chem. 2011, 19, 2785-2789.
35.
Oizumi, Y.; Mohri, Y.; Hattori, Y.; Makabe, H. Efficient Stereoselective Synthesis of Catechin Trimer Derivative Using Silver Lewis Acid Catalyzed Equimolar Condensation, Heterocycles 2011, 83, 739-742.
36.
Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K. Synthesis of Solamin Type mono-THF Acetogenins Using Cross-Metathesis, Tetrahedron 2010, 66, 7946-7953.
37.
Oasa, M.; Hattori, Y.; Konno, H.; Makabe, H. Synthesis of Annonacin Isolated from Annona densicoma, Biosci. Biotechnol. Biochem. 2010, 74, 1274-1275.
38.
Sekimoto, M.; Hattori, Y.; Morimura, K.; Hirota, M.; Makabe, H. Asymmetric Syntheses of Daedalin A and Quercinol and Their Tyrosinase Inhibitory Activity, Bioorg. Med. Chem. Lett. 2010, 20, 1063-1064.
39.
Mohri, Y.; Sagehashi, M.; Yamada, T.; Hattori, Y.; Morimura, K.; Hamauzu, Y.; Kamo, T.; Hirota, M.; Makabe, H. An Efficient Synthesis of Procyanidins Using Equimolar Condensation of Catechin and/or Epicatechin Catalyzed by Ytterbium Triflate, Heterocycles 2009, 79, 549-563.
40.
Iijima, T.; Mohri, Y.; Hattori, Y.; Kashima, A.; Kamo, T.; Hirota, M.; Kiyota, H.; Makabe, H. Synthesis of (ー)-Epicatechin 3-(3-O-Methylgallate) and (+)-Catechin 3-(3-O-Methylgallate), and Their Anti-inflammatory Activity, Chemistry & Biodiversity 2009, 6, 520-526.
41.
Morimura, K.; Hiramatsu, K.; Yamazaki, C.; Hattori, Y.; Makabe, H.; Hirota, M. Daedalin A, a Metabolite of Daedalea dickinsii, Inhibits Melanin Synthesis in an in vitro Human Skin Model, Biosci. Biotechnol. Biochem. 2009, 73, 627-632.
42.
Makabe, H.; Kuwabara, A.; Hattori, Y.; Konno, H. A Concise Synthesis of Solamin and cis-Solamin, mono-THF Acetogenins from Annona muricata, Heterocycles 2009, 78, 2369-2376.
43.
Furuhata, S.; Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H. Synthesis of Pyranicin and Its Deoxygenated Analogues and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I, Tetrahedron 2008, 64, 7695-7703.
44.
Abe, M.; Kubo, A.; Yamamoto, S.; Hatoh, Y.; Murai, M.; Hattori, Y.; Makabe, H.; Nishioka, T.; Miyoshi, H. Dynamic Function of the Spacer Region of Acetogenins in the Inhibition of Bovine Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I), Biochemistry 2008, 47, 6260-6266.
45.
Hattori, Y.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H. Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I, Org. Lett. 2008, 10, 717-720.
46.
Morimura, K.; Yamazaki, C.; Hattori, Y.; Makabe, H.; Kamo, T.; Hirota, M. A Tyrosinase Inhibitor, Daedalin A, from Mycelial Culture of Daedalea dickinsii, Biosci. Biotechnol. Biochem. 2007, 71, 2837-2840.
47.
Mohri, Y.; Sagehashi, M.; Yamada, T.; Hattori, Y.; Morimura, K.; Kamo, T.; Hirota, M.; Makabe, H. An Efficient Synthesis of Procyanidins. Rare Earth Metal Lewis Acid Catalyzed Equimolar Condensation of Catechin and Epicatechin, Tetrahedron Lett. 2007, 48, 5891-5894.
48.
Hattori, Y.; Horikawa, K.; Makabe, H.; Hirai, N.; Hirota, M.; Kamo, T. A Refined Method for Determining the Absolute Configuration of the 3-Hydroxy-3-methylglutaryl Group, Tetrahedron: Asymmetry 2007, 18, 1183-1186.
49.
Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H. Synthesis, Determination of the Absolute Configuration of Tonkinelin, and Inhibitory Action with Bovine Heart Mitochondrial Complex I, Bioorg. Med. Chem. 2007, 15, 3026-3031.
50.
Hattori, Y.; Kimura, Y.; Moroda, A.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H. Synthesis of Murisolin, (15R,16R,19R,20S)-Murisolin A, and (15R,16R,19S,20S)-16,19-cis-Murisolin, and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I, Chem. Asian J. 2006, 1, 894-904.
51.
Makabe, H.; Hattori, Y.; Kimura, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Tanaka, A.; Oritani, T. Total Synthesis of cis-Solamin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I, Tetrahedron 2004, 60, 10651-10657.
52.
Makabe, H.; Miyawaki, A.; Takahashi, R.; Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H. Synthesis of Two Possible Diastereomers of Reticulatain-1, Tetrahedron Lett. 2004, 45, 973-977.
53.
Makabe, H.; Hattori, Y.; Tanaka, A.; Oritani, T. Total Synthesis of cis-Solamin, Org. Lett. 2002, 4, 1083-1085.


総説
1.
Hattori, Y.; Makabe, H. in: A. Rahman (Ed.), The biological activities and synthesis of 2,6-disubstituted piperidinols, Frontiers in Natural Product Chemistry, Volume 3, Chapter 5, pp. 196-220, Bentham Science, 2017.1.
2.
野坂和人、江嵜啓祥、小野塚真理、今野博行、服部恭尚、赤路健一、「酵母の転写因子Pdc2によるチアミン依存性転写誘導機構」、Vitamins (Japan)、2011、85、537-545.
2.
服部恭尚、今野博行、三芳秀人、真壁秀文、「バンレイシ科アセトゲニン類の合成とミトコンドリアcomplex I に対する阻害活性」、有機合成化学協会誌、2011、69、159-168.


特許
1.
芦原英司、服部恭尚、赤路健一、「Wntシグナル伝達経路阻害剤」、学校法人京都薬科大学、特願2018-237943・特願2019-2015
2.
森村佳司、廣田満、服部恭尚、真壁秀文、「クロマン化合物およびその製造方法」、ゲオール化学株式会社、国立大学法人信州大学、特許第5212969号（出願：2007年）
3.
真壁秀文、提箸正義、山田大士、毛利圭宏、服部恭尚、「プロシアニジンB1-B4およびカテキン重合体の製造方法」、ゲオール化学株式会社、国立大学法人信州大学、特開 公開番号2007-84536
4.
森村佳司、土村敦子、道籏孝彦、長井克介、山崎千尋、廣田満、服部恭尚、真壁秀文、「美白剤および抗酸化剤ならびに活性酸素除去剤」、ゲオール化学株式会社、国立大学法人信州大学、特許第5049480号（出願：2005年）