2004研究業績

2004

1.     Yusuke Adachi and Hiromu Sakurai: Insulin-mimetic Vanadyl(IV) complexes as evaluated by both glucose-uptake and inhibition of free fatty acids (FFA)-release in isolated rat adipocytes. Chem. Pharm. Bull., 52(4), 428-433 (2004).

2.     Hiromu Sakurai, Toshifumi Inohara, Yusuke Adachi, Keiji Kawabe, Hiroyuki Yasui and Jitsuya Takada: A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate. Bioorg. Med. Chem. Lett., 14(5) 1093-1096 (2004).

3.     Pabla Noblía, Enrique J. Baran, Lucía Otero, Patricia Draper, Hugo Cerecetto, Mercedes González, Oscar E. Piro, Eduardo E. Castellano, Toshifumi Inohara, Yusuke Adachi, Hiromu Sakurai and Dinorah Gambino: New vanadium(V) complexes with salicylaldehyde semicarbazone derivatives: synthesis, characterization, and in vitro insulin-mimetic activity−crystal structure of [V^vO₂(salicylaldehyde semicarbazone)]. Eur. J. Inorg. Chem., 2004(2), 322-328 (2004).

4.     Eriko Ueda, Yutaka Yoshikawa, Noriko Kishimoto, Makoto Tadokoro, Hiromu Sakurai, Naemi Kajiwara and Yoshitane Kojima: New bioactive zinc(II) complexes with peptides and their derivatives: synthesis, structure, and in vitro insulinomimetic activity. Bull. Chem. Soc. Jpn., 77(5), 981-986 (2004).

5.     Yutaka Yoshikawa, Eriko Ueda, Yoshitane Kojima and Hiromu Sakurai: The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes. Life Sci., 75(6), 741-751 (2004).

6.     Akira Katoh, Mika Yamaguchi, Ryota Saito, Yusuke Adachi and Hiromu Sakurai: Insulinomimetic vanadyl-hydroxythiazolethione complexes with VO(S₂O₂) coordination mode: the correlation between the activity and Hammett’s substituent constant. Chem. Lett., 33(10), 1274-1275 (2004).

7.     Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera, Akira Kato, Yutaka Yoshikawa, Yoshitane Kojima and Hiromu Sakurai: A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes. J. Biol. Inorg. Chem., 9(7), 885-893 (2004).

8.     Hiromu Sakurai, Jun Fugono and Hiroyuki Yasui: Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds: implications for clinical use. Mini-Reviews in Med. Chem., 4(1), 41-48 (2004). [Review]

9.     Misaki Nakai, Makoto Obata, Fumi Sekiguchi, Masako Kato, Motoo Shiro, Akio Ichimura, Isamu Kinoshita, Masahiro Mikuriya, Toshifumi Inohara, Kenji Kawabe, Hiromu Sakurai, Chris Orvig and Shigenobu Yano: Synthesis and insulinomimetic activities of novel mono- and tetranuclear oxovanadium(IV) complexes with 3-hydroxypyridine-2-carboxylic acid. J. Inorg. Biochem., 98(1), 105-112 (2004).

10. Yusuke Adachi, Ippei Motomura, Rie Ueda, Hiroyuki Yasui, Ayako Kiyomasu, Jitsuya Takada and Hiromu Sakurai: The physiological effects of the undercurrent water from Mt. Fuji on type 2 diabetic KK-A^ymice. Biomed. Res. Trace Elements, 15(1), 76-78 (2004).

11. Yusuke Adachi and Hiromu Sakurai: Comparative study of insulin-mimetic activity of and zinc complexes. Biomed. Res. Trace Elements, 15(4), 351-354 (2004).

12. Misaki Nakai, Makoto Obata, Fumi Sekiguchi, Masako Kato, Motoo Shiro, Akio Ichimura, Isamu Kinoshita, Masahiro Mikuriya, Toshifumi Inohara, Kenji Kawabe, Hiromu Sakurai, Chris Orvig and Shigenobu Yano: Synthesis and insulinomimetic activities of novel mono-and tetranuclear oxovanadium(ⅠⅤ)complexes with 3-hydroxyridine-2-carboxylic acid. J. Inorg. Biochem., 98(1), 105-112 (2004).

13. Sunsuke Nakamura, Takumi Kawata, Akihiro Nakayama, Kanenobu Kubo, Takeshi Minami and Hiromu Sakurai: Implication of the differential roles of metallotionein 1 and 2 isoforms in the liver of rats as determined by polyacrylamid-coated capillary zone electrophoresis. Biochem. Biophys. Res. Commun., 320(4), 1193-1198 (2004).

14. Hiroyuki Yasui, Satoshi Fujii, Tetsuhiko Yoshimura, and Hiromu Sakurai: Spinnokinetic analyses of blood disposition and bilary excretion of nitric oxide (NO)-Fe(Ⅱ)-N-(dithiocarboxy) sarcosine complex in rats: BCM-ESR and BEM-ESR studies. Free Radical Res., 38(10), 1061-1072 (2004)

15. 田和理市、桜井　弘: メタロチオネイン-ⅡA 遺伝子発現に対する　DNAへの金属結合の解析. Biomed Res. Trace Elements, 15(3), 281-283 (2004).

16. 安井裕之, 池田亜以子, 重本真理子, 桜井　弘: 紫外線により生成される皮膚中の活性酸素種に対するラベンダーオイルの抑制作用－紫外線障害防御と皮膚老化抑制への可能性－. Aroma Research, 5(2), 129(31)-136(37) (2004).

17. 山元周平, 吉川　豊, 植田英里好, 山下徹志, 梶原苗美, 桜井　弘, 小嶋良種: ハロゲン化ピコリン酸誘導体/亜鉛(II)錯体のインスリン様作用. Biomed. Res. Trace Elements, 15(1), 85-87 (2004).

18. 桜井　弘: ミネラルの利用と生体機能. 月刊フードケミカル, 4, 19-24 (2004). [Review]

19. 桜井　弘: バナジウム. 日本臨床社, 62(12) 322-325, (2004). [Review]

20. 安達祐介, 吉田治郎, 小寺幸広, 加藤明良, 吉川　豊, 桜井　弘: 亜鉛(II)-アリキシン錯体のインスリン様作用. Trace Nutri. Res., 21, 73-76 (2004)

特許

1.       ①特許公開番号: 特開　2004-99573. ②公開日:2004.4.2. ③発明の名称: 血液流動性亢進作用を有する亜鉛含有物. ④出願人: 有田順一. ⑤発明者: 小嶋良種, 吉川　豊, 梶原苗美, 安西弘子, 谷口　洋, 有田順一.

2.       ①特許公開番号: 特開　2004-155766. ②公開日: 2004.6.3. ③発明の名称: 血糖降下作用を有する亜鉛含有物. ④出願人: 有田順一. ⑤発明者: 小嶋良種, 吉川　豊, 梶原苗美, 桜井　弘.

3.       ①特許公開番号: 特開　2004-166690 ②公開日: 2004.6.3 ③発明の名称: 抗酸化作用を有する亜鉛含有物 ④出願人: 有田順一 ⑤発明者: 小嶋良種, 吉川　豊, 玄番宗一, 河合悦子, 幸田祐佳.

4.       ①特許公開番号: 特開　2004-201675 ②公開日: 2004.6.17 ③発明の名称: α-グルコシターゼ阻害作用を有する亜鉛含有物 ④出願人: 有田順一 ⑤発明者: 小嶋良種, 吉川　豊, 梶原苗美, 谷口　洋.

5.       ①特許公開番号: 特開　2004-201675 ②公開日: 2004.7.22 ③発明の名称: 糖尿病予防効果を有する亜鉛高含有物 ④出願人: 有田順一 ⑤発明者: 小嶋良種, 吉川　豊, 梶原苗美, 安西弘子, 谷口　洋.

6.       ①特許公開番号: 特開　2004-229656 ②公開日: ③発明の名称植物を用いた亜鉛(Ⅱ)高含有天然物 ④出願人: 有田順一 ⑤発明者: 小嶋良種, 吉川　豊, 玄番宗一, 河合悦子, 幸田祐佳.

7.       ①特許公開番号: 特開　2004-277308 ②公開日: 2004.10.7. ③発明の名称: 紫外線誘導活性酸素抑制剤 ④出願人: 三井物産株式会社, 株式会社アクアクララ, 株式会社日本食品開発研究所 . ⑤発明者: 桜井　弘, 安井裕之.